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RDX (radixin)

Identity

Alias (NCBI)DFNB24
HGNC (Hugo) RDX
HGNC Previous nameDFNB24
HGNC Previous namedeafness, autosomal recessive 24
LocusID (NCBI) 5962
Atlas_Id 50787
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 110229441 and ends at 110296614 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTR1B (2q11.2)::RDX (11q22.3)CDC42BPA (1q42.13)::RDX (11q22.3)NCOR1 (17p12)::RDX (11q22.3)
PLXND1 (3q22.1)::RDX (11q22.3)RDX (11q22.3)::NXPH4 (12q13.3)RPL7A (9q34.2)::RDX (11q22.3)
WAC (10p12.1)::RDX (11q22.3)WAC 10p12.1::RDX 11q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RDX   9944
Cards
Entrez_Gene (NCBI)RDX    radixin
AliasesDFNB24
GeneCards (Weizmann)RDX
Ensembl hg19 (Hinxton)ENSG00000137710 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137710 [Gene_View]  ENSG00000137710 [Sequence]  chr11:110229441-110296614 [Contig_View]  RDX [Vega]
ICGC DataPortalENSG00000137710
TCGA cBioPortalRDX
AceView (NCBI)RDX
Genatlas (Paris)RDX
SOURCE (Princeton)RDX
Genetics Home Reference (NIH)RDX
Genomic and cartography
GoldenPath hg38 (UCSC)RDX  -     chr11:110229441-110296614 -  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RDX  -     11q22.3   [Description]    (hg19-Feb_2009)
GoldenPathRDX - 11q22.3 [CytoView hg19]  RDX - 11q22.3 [CytoView hg38]
ImmunoBaseENSG00000137710
Genome Data Viewer NCBIRDX [Mapview hg19]  
OMIM179410   611022   
Gene and transcription
Genbank (Entrez)AF086024 AK295075 AK312903 AK316061 BC002626
RefSeq transcript (Entrez)NM_001260492 NM_001260493 NM_001260494 NM_001260495 NM_001260496 NM_002906
Consensus coding sequences : CCDS (NCBI)RDX
Gene ExpressionRDX [ NCBI-GEO ]   RDX [ EBI - ARRAY_EXPRESS ]   RDX [ SEEK ]   RDX [ MEM ]
Gene Expression Viewer (FireBrowse)RDX [ Firebrowse - Broad ]
GenevisibleExpression of RDX in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5962
GTEX Portal (Tissue expression)RDX
Human Protein AtlasENSG00000137710-RDX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35241   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35241  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35241
PhosPhoSitePlusP35241
Domaine pattern : Prosite (Expaxy)FERM_1 (PS00660)    FERM_2 (PS00661)    FERM_3 (PS50057)   
Domains : Interpro (EBI)Band_41_domain    ERM    ERM_C_dom    ERM_FERM_C    Ez/rad/moesin-like    FERM/acyl-CoA-bd_prot_sf    FERM_2    FERM_central    FERM_CS    FERM_domain    FERM_N    FERM_PH-like_C    Moesin_tail_sf    PH-like_dom_sf    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)ERM (PF00769)    FERM_C (PF09380)    FERM_M (PF00373)    FERM_N (PF09379)   
Domain families : Pfam (NCBI)pfam00769    pfam09380    pfam00373    pfam09379   
Domain families : Smart (EMBL)B41 (SM00295)  FERM_C (SM01196)  
Conserved Domain (NCBI)RDX
SuperfamilyP35241
AlphaFold pdb e-kbP35241   
Human Protein Atlas [tissue]ENSG00000137710-RDX [tissue]
HPRD01534
Protein Interaction databases
DIP (DOE-UCLA)P35241
IntAct (EBI)P35241
BioGRIDRDX
STRING (EMBL)RDX
ZODIACRDX
Ontologies - Pathways
QuickGOP35241
Ontology : AmiGORNA binding  actin binding  protein binding  extracellular space  plasma membrane  plasma membrane  microvillus  adherens junction  focal adhesion  focal adhesion  regulation of cell shape  regulation of cell size  positive regulation of gene expression  protein kinase A signaling  apical plasma membrane  lamellipodium  filopodium  T-tubule  positive regulation of cell migration  midbody  cortical actin cytoskeleton  cleavage furrow  regulation of actin filament bundle assembly  regulation of Rap protein signal transduction  negative regulation of homotypic cell-cell adhesion  negative regulation of GTPase activity  cellular response to platelet-derived growth factor stimulus  regulation of GTPase activity  apical protein localization  establishment of protein localization  cadherin binding  negative regulation of cell size  barbed-end actin filament capping  protein kinase A binding  ATPase binding  cell tip  establishment of endothelial barrier  extracellular exosome  cell periphery  protein localization to plasma membrane  cellular response to thyroid hormone stimulus  regulation of ruffle assembly  positive regulation of G1/S transition of mitotic cell cycle  regulation of organelle assembly  positive regulation of protein localization to early endosome  positive regulation of cellular protein catabolic process  negative regulation of adherens junction organization  positive regulation of early endosome to late endosome transport  
Ontology : EGO-EBIRNA binding  actin binding  protein binding  extracellular space  plasma membrane  plasma membrane  microvillus  adherens junction  focal adhesion  focal adhesion  regulation of cell shape  regulation of cell size  positive regulation of gene expression  protein kinase A signaling  apical plasma membrane  lamellipodium  filopodium  T-tubule  positive regulation of cell migration  midbody  cortical actin cytoskeleton  cleavage furrow  regulation of actin filament bundle assembly  regulation of Rap protein signal transduction  negative regulation of homotypic cell-cell adhesion  negative regulation of GTPase activity  cellular response to platelet-derived growth factor stimulus  regulation of GTPase activity  apical protein localization  establishment of protein localization  cadherin binding  negative regulation of cell size  barbed-end actin filament capping  protein kinase A binding  ATPase binding  cell tip  establishment of endothelial barrier  extracellular exosome  cell periphery  protein localization to plasma membrane  cellular response to thyroid hormone stimulus  regulation of ruffle assembly  positive regulation of G1/S transition of mitotic cell cycle  regulation of organelle assembly  positive regulation of protein localization to early endosome  positive regulation of cellular protein catabolic process  negative regulation of adherens junction organization  positive regulation of early endosome to late endosome transport  
Pathways : KEGGRegulation of actin cytoskeleton    Proteoglycans in cancer    MicroRNAs in cancer   
NDEx NetworkRDX
Atlas of Cancer Signalling NetworkRDX
Wikipedia pathwaysRDX
Orthology - Evolution
OrthoDB5962
GeneTree (enSembl)ENSG00000137710
Phylogenetic Trees/Animal Genes : TreeFamRDX
Homologs : HomoloGeneRDX
Homology/Alignments : Family Browser (UCSC)RDX
Gene fusions - Rearrangements
Fusion : MitelmanWAC::RDX [10p12.1/11q22.3]  
Fusion : QuiverRDX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRDX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RDX
dbVarRDX
ClinVarRDX
MonarchRDX
1000_GenomesRDX 
Exome Variant ServerRDX
GNOMAD BrowserENSG00000137710
Varsome BrowserRDX
ACMGRDX variants
VarityP35241
Genomic Variants (DGV)RDX [DGVbeta]
DECIPHERRDX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRDX 
Mutations
ICGC Data PortalRDX 
TCGA Data PortalRDX 
Broad Tumor PortalRDX
OASIS PortalRDX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRDX  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRDX
Mutations and Diseases : HGMDRDX
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRDX
DgiDB (Drug Gene Interaction Database)RDX
DoCM (Curated mutations)RDX
CIViC (Clinical Interpretations of Variants in Cancer)RDX
Cancer3DRDX
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179410    611022   
Orphanet12047   
DisGeNETRDX
MedgenRDX
Genetic Testing Registry RDX
NextProtP35241 [Medical]
GENETestsRDX
Target ValidationRDX
Huge Navigator RDX [HugePedia]
ClinGenRDX
Clinical trials, drugs, therapy
MyCancerGenomeRDX
Protein Interactions : CTDRDX
Pharm GKB GenePA34311
PharosP35241
Clinical trialRDX
Miscellaneous
canSAR (ICR)RDX
HarmonizomeRDX
ARCHS4RDX
DataMed IndexRDX
Probes
Litterature
PubMed147 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRDX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:30:53 CET 2022

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