Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RDX (radixin)

Identity

Alias_namesDFNB24
deafness
Other alias
HGNC (Hugo) RDX
LocusID (NCBI) 5962
Atlas_Id 50787
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 110195561 and ends at 110296712 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACTR1B (2q11.2) / RDX (11q22.3)CDC42BPA (1q42.13) / RDX (11q22.3)NCOR1 (17p12) / RDX (11q22.3)
PLXND1 (3q22.1) / RDX (11q22.3)RDX (11q22.3) / NXPH4 (12q13.3)RPL7A (9q34.2) / RDX (11q22.3)
WAC (10p12.1) / RDX (11q22.3)WAC 10p12.1 / RDX 11q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RDX   9944
Cards
Entrez_Gene (NCBI)RDX  5962  radixin
AliasesDFNB24
GeneCards (Weizmann)RDX
Ensembl hg19 (Hinxton)ENSG00000137710 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137710 [Gene_View]  chr11:110195561-110296712 [Contig_View]  RDX [Vega]
ICGC DataPortalENSG00000137710
TCGA cBioPortalRDX
AceView (NCBI)RDX
Genatlas (Paris)RDX
WikiGenes5962
SOURCE (Princeton)RDX
Genetics Home Reference (NIH)RDX
Genomic and cartography
GoldenPath hg38 (UCSC)RDX  -     chr11:110195561-110296712 -  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RDX  -     11q22.3   [Description]    (hg19-Feb_2009)
EnsemblRDX - 11q22.3 [CytoView hg19]  RDX - 11q22.3 [CytoView hg38]
Mapping of homologs : NCBIRDX [Mapview hg19]  RDX [Mapview hg38]
OMIM179410   611022   
Gene and transcription
Genbank (Entrez)AF086024 AK295075 AK312903 AK316061 BC002626
RefSeq transcript (Entrez)NM_001260492 NM_001260493 NM_001260494 NM_001260495 NM_001260496 NM_002906
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RDX
Cluster EST : UnigeneHs.741211 [ NCBI ]
CGAP (NCI)Hs.741211
Alternative Splicing GalleryENSG00000137710
Gene ExpressionRDX [ NCBI-GEO ]   RDX [ EBI - ARRAY_EXPRESS ]   RDX [ SEEK ]   RDX [ MEM ]
Gene Expression Viewer (FireBrowse)RDX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5962
GTEX Portal (Tissue expression)RDX
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35241   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35241  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35241
Splice isoforms : SwissVarP35241
PhosPhoSitePlusP35241
Domaine pattern : Prosite (Expaxy)FERM_1 (PS00660)    FERM_2 (PS00661)    FERM_3 (PS50057)   
Domains : Interpro (EBI)Band_41_domain    ERM    ERM_C_dom    Ez/rad/moesin-like    FERM/acyl-CoA-bd_prot_3-hlx    FERM_central    FERM_CS    FERM_domain    FERM_N    FERM_PH-like_C    Moesin_tail    PH_dom-like    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)ERM (PF00769)    FERM_C (PF09380)    FERM_M (PF00373)    FERM_N (PF09379)   
Domain families : Pfam (NCBI)pfam00769    pfam09380    pfam00373    pfam09379   
Domain families : Smart (EMBL)B41 (SM00295)  FERM_C (SM01196)  
Conserved Domain (NCBI)RDX
DMDM Disease mutations5962
Blocks (Seattle)RDX
SuperfamilyP35241
Human Protein AtlasENSG00000137710
Peptide AtlasP35241
HPRD01534
IPIIPI00903145   IPI01009289   IPI00816261   IPI00984304   IPI00017367   IPI00982668   IPI00869155   IPI00980793   IPI00984046   IPI00977874   IPI00981209   IPI00978853   IPI00983109   
Protein Interaction databases
DIP (DOE-UCLA)P35241
IntAct (EBI)P35241
FunCoupENSG00000137710
BioGRIDRDX
STRING (EMBL)RDX
ZODIACRDX
Ontologies - Pathways
QuickGOP35241
Ontology : AmiGOruffle  RNA binding  actin binding  protein binding  extracellular space  plasma membrane  plasma membrane  microvillus  cell-cell adherens junction  focal adhesion  focal adhesion  regulation of cell shape  regulation of cell size  positive regulation of gene expression  protein kinase A signaling  apical plasma membrane  extrinsic component of membrane  protein domain specific binding  lamellipodium  microvillus assembly  filopodium  T-tubule  positive regulation of cell migration  midbody  cortical actin cytoskeleton  cleavage furrow  regulation of actin filament bundle assembly  stereocilium  regulation of Rap protein signal transduction  negative regulation of homotypic cell-cell adhesion  negative regulation of GTPase activity  cellular response to platelet-derived growth factor stimulus  protein homodimerization activity  regulation of GTPase activity  myelin sheath  apical protein localization  establishment of protein localization  cadherin binding  negative regulation of cell size  barbed-end actin filament capping  protein kinase A binding  ATPase binding  cell tip  establishment of endothelial barrier  extracellular exosome  cell periphery  establishment of protein localization to plasma membrane  cellular response to thyroid hormone stimulus  regulation of ruffle assembly  positive regulation of G1/S transition of mitotic cell cycle  regulation of organelle assembly  positive regulation of protein localization to early endosome  positive regulation of cellular protein catabolic process  negative regulation of adherens junction organization  positive regulation of early endosome to late endosome transport  
Ontology : EGO-EBIruffle  RNA binding  actin binding  protein binding  extracellular space  plasma membrane  plasma membrane  microvillus  cell-cell adherens junction  focal adhesion  focal adhesion  regulation of cell shape  regulation of cell size  positive regulation of gene expression  protein kinase A signaling  apical plasma membrane  extrinsic component of membrane  protein domain specific binding  lamellipodium  microvillus assembly  filopodium  T-tubule  positive regulation of cell migration  midbody  cortical actin cytoskeleton  cleavage furrow  regulation of actin filament bundle assembly  stereocilium  regulation of Rap protein signal transduction  negative regulation of homotypic cell-cell adhesion  negative regulation of GTPase activity  cellular response to platelet-derived growth factor stimulus  protein homodimerization activity  regulation of GTPase activity  myelin sheath  apical protein localization  establishment of protein localization  cadherin binding  negative regulation of cell size  barbed-end actin filament capping  protein kinase A binding  ATPase binding  cell tip  establishment of endothelial barrier  extracellular exosome  cell periphery  establishment of protein localization to plasma membrane  cellular response to thyroid hormone stimulus  regulation of ruffle assembly  positive regulation of G1/S transition of mitotic cell cycle  regulation of organelle assembly  positive regulation of protein localization to early endosome  positive regulation of cellular protein catabolic process  negative regulation of adherens junction organization  positive regulation of early endosome to late endosome transport  
Pathways : KEGGRegulation of actin cytoskeleton    Proteoglycans in cancer    MicroRNAs in cancer   
NDEx NetworkRDX
Atlas of Cancer Signalling NetworkRDX
Wikipedia pathwaysRDX
Orthology - Evolution
OrthoDB5962
GeneTree (enSembl)ENSG00000137710
Phylogenetic Trees/Animal Genes : TreeFamRDX
HOVERGENP35241
HOGENOMP35241
Homologs : HomoloGeneRDX
Homology/Alignments : Family Browser (UCSC)RDX
Gene fusions - Rearrangements
Fusion : MitelmanWAC/RDX [10p12.1/11q22.3]  [t(10;11)(p12;q22)]  
Fusion: TCGAWAC 10p12.1 RDX 11q22.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRDX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RDX
dbVarRDX
ClinVarRDX
1000_GenomesRDX 
Exome Variant ServerRDX
ExAC (Exome Aggregation Consortium)RDX (select the gene name)
Genetic variants : HAPMAP5962
Genomic Variants (DGV)RDX [DGVbeta]
DECIPHERRDX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRDX 
Mutations
ICGC Data PortalRDX 
TCGA Data PortalRDX 
Broad Tumor PortalRDX
OASIS PortalRDX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRDX  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRDX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch RDX
DgiDB (Drug Gene Interaction Database)RDX
DoCM (Curated mutations)RDX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RDX (select a term)
intoGenRDX
Cancer3DRDX(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179410    611022   
Orphanet12047   
MedgenRDX
Genetic Testing Registry RDX
NextProtP35241 [Medical]
TSGene5962
GENETestsRDX
Huge Navigator RDX [HugePedia]
snp3D : Map Gene to Disease5962
BioCentury BCIQRDX
ClinGenRDX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5962
Chemical/Pharm GKB GenePA34311
Clinical trialRDX
Miscellaneous
canSAR (ICR)RDX (select the gene name)
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRDX
EVEXRDX
GoPubMedRDX
iHOPRDX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:34:39 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.