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REG3A (regenerating family member 3 alpha)

Identity

Alias_namesPAP
pancreatitis-associated protein
regenerating islet-derived 3 alpha
Alias_symbol (synonym)HIP
REG-III
REG3
PBCGF
PAP1
Other aliasHIP/PAP
INGAP
PAP-H
HGNC (Hugo) REG3A
LocusID (NCBI) 5068
Atlas_Id 487
Location 2p12  [Link to chromosome band 2p12]
Location_base_pair Starts at 79157006 and ends at 79159754 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NDE1 (16p13.11) / REG3A (2p12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)REG3A   8601
Cards
Entrez_Gene (NCBI)REG3A  5068  regenerating family member 3 alpha
AliasesHIP; HIP/PAP; INGAP; PAP; 
PAP-H; PAP1; PBCGF; REG-III; REG3
GeneCards (Weizmann)REG3A
Ensembl hg19 (Hinxton)ENSG00000172016 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172016 [Gene_View]  chr2:79157006-79159754 [Contig_View]  REG3A [Vega]
ICGC DataPortalENSG00000172016
TCGA cBioPortalREG3A
AceView (NCBI)REG3A
Genatlas (Paris)REG3A
WikiGenes5068
SOURCE (Princeton)REG3A
Genetics Home Reference (NIH)REG3A
Genomic and cartography
GoldenPath hg38 (UCSC)REG3A  -     chr2:79157006-79159754 -  2p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)REG3A  -     2p12   [Description]    (hg19-Feb_2009)
EnsemblREG3A - 2p12 [CytoView hg19]  REG3A - 2p12 [CytoView hg38]
Mapping of homologs : NCBIREG3A [Mapview hg19]  REG3A [Mapview hg38]
OMIM167805   
Gene and transcription
Genbank (Entrez)AK291973 AK311523 AK311526 AY544128 AY544130
RefSeq transcript (Entrez)NM_002580 NM_138937 NM_138938
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)REG3A
Cluster EST : UnigeneHs.567312 [ NCBI ]
CGAP (NCI)Hs.567312
Alternative Splicing GalleryENSG00000172016
Gene ExpressionREG3A [ NCBI-GEO ]   REG3A [ EBI - ARRAY_EXPRESS ]   REG3A [ SEEK ]   REG3A [ MEM ]
Gene Expression Viewer (FireBrowse)REG3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5068
GTEX Portal (Tissue expression)REG3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ06141   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ06141  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ06141
Splice isoforms : SwissVarQ06141
PhosPhoSitePlusQ06141
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_1 (PS00615)    C_TYPE_LECTIN_2 (PS50041)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link    C-type_lectin_CS    CTDL_fold   
Domain families : Pfam (Sanger)Lectin_C (PF00059)   
Domain families : Pfam (NCBI)pfam00059   
Domain families : Smart (EMBL)CLECT (SM00034)  
Conserved Domain (NCBI)REG3A
DMDM Disease mutations5068
Blocks (Seattle)REG3A
PDB (SRS)1UV0    2GO0    4MTH   
PDB (PDBSum)1UV0    2GO0    4MTH   
PDB (IMB)1UV0    2GO0    4MTH   
PDB (RSDB)1UV0    2GO0    4MTH   
Structural Biology KnowledgeBase1UV0    2GO0    4MTH   
SCOP (Structural Classification of Proteins)1UV0    2GO0    4MTH   
CATH (Classification of proteins structures)1UV0    2GO0    4MTH   
SuperfamilyQ06141
Human Protein AtlasENSG00000172016
Peptide AtlasQ06141
HPRD01342
IPIIPI00029039   
Protein Interaction databases
DIP (DOE-UCLA)Q06141
IntAct (EBI)Q06141
FunCoupENSG00000172016
BioGRIDREG3A
STRING (EMBL)REG3A
ZODIACREG3A
Ontologies - Pathways
QuickGOQ06141
Ontology : AmiGOprotein binding  extracellular region  extracellular space  cytoplasm  acute-phase response  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  multicellular organism development  cell proliferation  positive regulation of keratinocyte proliferation  antimicrobial humoral response  carbohydrate binding  negative regulation of keratinocyte differentiation  positive regulation of wound healing  
Ontology : EGO-EBIprotein binding  extracellular region  extracellular space  cytoplasm  acute-phase response  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  multicellular organism development  cell proliferation  positive regulation of keratinocyte proliferation  antimicrobial humoral response  carbohydrate binding  negative regulation of keratinocyte differentiation  positive regulation of wound healing  
NDEx NetworkREG3A
Atlas of Cancer Signalling NetworkREG3A
Wikipedia pathwaysREG3A
Orthology - Evolution
OrthoDB5068
GeneTree (enSembl)ENSG00000172016
Phylogenetic Trees/Animal Genes : TreeFamREG3A
HOVERGENQ06141
HOGENOMQ06141
Homologs : HomoloGeneREG3A
Homology/Alignments : Family Browser (UCSC)REG3A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerREG3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)REG3A
dbVarREG3A
ClinVarREG3A
1000_GenomesREG3A 
Exome Variant ServerREG3A
ExAC (Exome Aggregation Consortium)REG3A (select the gene name)
Genetic variants : HAPMAP5068
Genomic Variants (DGV)REG3A [DGVbeta]
DECIPHERREG3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisREG3A 
Mutations
ICGC Data PortalREG3A 
TCGA Data PortalREG3A 
Broad Tumor PortalREG3A
OASIS PortalREG3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICREG3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDREG3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch REG3A
DgiDB (Drug Gene Interaction Database)REG3A
DoCM (Curated mutations)REG3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)REG3A (select a term)
intoGenREG3A
Cancer3DREG3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM167805   
Orphanet
MedgenREG3A
Genetic Testing Registry REG3A
NextProtQ06141 [Medical]
TSGene5068
GENETestsREG3A
Target ValidationREG3A
Huge Navigator REG3A [HugePedia]
snp3D : Map Gene to Disease5068
BioCentury BCIQREG3A
ClinGenREG3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5068
Chemical/Pharm GKB GenePA32931
Clinical trialREG3A
Miscellaneous
canSAR (ICR)REG3A (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineREG3A
EVEXREG3A
GoPubMedREG3A
iHOPREG3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:05:37 CEST 2017

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