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RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian))

Written2002-01Fei Chen
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)NF-kB3
NF-kB p65
HGNC (Hugo) RELA
HGNC Alias symbp65
HGNC Previous nameNFKB3
HGNC Previous namenuclear factor of kappa light polypeptide gene enhancer in B-cells 3
 v-rel avian reticuloendotheliosis viral oncogene homolog A
LocusID (NCBI) 5970
Atlas_Id 325
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65653601 and ends at 65662916 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping RELA.png]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTB (7p22.1)::RELA (11q13.1)C11orf95 (11q13.1)::RELA (11q13.1)LGALS4 (19q13.2)::RELA (11q13.1)
RELA (11q13.1)::C16orf45 (16p13.11)ZMYND8 (20q13.12)::RELA (11q13.1)
Note see also, in the Deep Insight section: Upstream Signal Transduction of NF-kB Activation

DNA/RNA

Description The gene encoding human RelA has 10 exons spanning 8.1 kb. The shorter variants of RelA (p65d) can be generated by alternative splicing of intron 1, 6, or 7. The p65d1 lacks codons for amino acids 222 to 231 and p65d2 lacks codons for amino acids 13 to 25 of the conserved Rel homology domain. An additional alternative splicing form of p65, p65d3 has been identified in a non-small-cell lung carcinoma cell line that lacks codons for amino acids 187 to 293 of the Rel homology domain.

Protein

Description The relA gene encodes a protein composed 551 amino acids with an approximately molecular weight of 65 kDa. The N-terminal region of RelA contains a Rel homology domain (RHD) followed by a nuclear localization signal. The C-terminal region of RelA contains a putative leucine zipper domain and a transactivation domain that is important for the NF-kB-mediated gene transactivation. A number of protein kinases can phosphorylate RelA and consequently potentiate the transcriptional activity of NF-kB complexes. These kinases include IKKb, PKA, and possibly GSK3 and MAP kinase p38. The phosphorylation of the transactivation domain of RelA was considered as an important event for the recruitment and/or interaction with co-factors and general transcriptional machinery subunits such as p300 and TFIIB.
Expression wide.
Localisation cytosol, nuclei after activation.
Function regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. The p50/RelA complex is the most abundant NF-kB complex in all type tissues or cells. Interaction with: members of IkB family and Rel family; GR; HDAC3; CREB; p300; Sp1, Egr1; AES; TFIIB.

Implicated in

Note
  
Entity cancer, autoimmune arthritis, glomerulonephritis, asthma, inflammatory bowel disease, septic shock, lung fibrosis, HTLV-1 infection, and AIDS.
Oncogenesis Chromosomal rearrangement or point mutation of relA gene has been implicated infrequently in human lymphoid tumors. A t(11;14)(q14;q32?) chromosomal translocation was described in 4 cases of lymphoproliferative disorders (LPD), which possibly involved p65 gene rearrangement. Gene amplification or increased expression of relA has also been noted in some cases of squamous carcinomas of head and neck, and in adenocarcinomas of breast and stomach.
  

Bibliography

The NF-kappa B and I kappa B proteins: new discoveries and insights.
Baldwin AS Jr
Annual review of immunology. 1996 ; 14 : 649-683.
PMID 8717528
 
Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing.
Deloukas P, van Loon AP
Human molecular genetics. 1993 ; 2 (11) : 1895-1900.
PMID 8281153
 
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.
Ghosh S, May MJ, Kopp EB
Annual review of immunology. 1998 ; 16 : 225-260.
PMID 9597130
 
Aberrant rel/nfkb genes and activity in human cancer.
Rayet B, Gélinas C
Oncogene. 1999 ; 18 (49) : 6938-6947.
PMID 10602468
 
A new characteristic karyotypic anomaly in lymphoproliferative disorders.
Van Den Berghe H, Parloir C, David G, Michaux JL, Sokal G
Cancer. 1979 ; 44 (1) : 188-195.
PMID 582293
 
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300.
Zhong H, Voll RE, Ghosh S
Molecular cell. 1998 ; 1 (5) : 661-671.
PMID 9660950
 

Citation

This paper should be referenced as such :
Chen, F
RELA (v-rel reticuloendotheliosis viral oncogene homolog A)
Atlas Genet Cytogenet Oncol Haematol. 2002;6(2):100-101.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Classical Hodgkin lymphoma
t(11;20)(q13;q13) ZMYND8::RELA


External links

 

Nomenclature
HGNC (Hugo)RELA   9955
Cards
AtlasRELAID325
Entrez_Gene (NCBI)RELA    RELA proto-oncogene, NF-kB subunit
AliasesCMCU; NFKB3; p65
GeneCards (Weizmann)RELA
Ensembl hg19 (Hinxton)ENSG00000173039 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173039 [Gene_View]  ENSG00000173039 [Sequence]  chr11:65653601-65662916 [Contig_View]  RELA [Vega]
ICGC DataPortalENSG00000173039
TCGA cBioPortalRELA
AceView (NCBI)RELA
Genatlas (Paris)RELA
SOURCE (Princeton)RELA
Genetics Home Reference (NIH)RELA
Genomic and cartography
GoldenPath hg38 (UCSC)RELA  -     chr11:65653601-65662916 -  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RELA  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathRELA - 11q13.1 [CytoView hg19]  RELA - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000173039
Genome Data Viewer NCBIRELA [Mapview hg19]  
OMIM164014   618287   
Gene and transcription
Genbank (Entrez)AK303262 AK308020 AK308478 BC011603 BC014095
RefSeq transcript (Entrez)NM_001145138 NM_001243984 NM_001243985 NM_021975
Consensus coding sequences : CCDS (NCBI)RELA
Gene ExpressionRELA [ NCBI-GEO ]   RELA [ EBI - ARRAY_EXPRESS ]   RELA [ SEEK ]   RELA [ MEM ]
Gene Expression Viewer (FireBrowse)RELA [ Firebrowse - Broad ]
GenevisibleExpression of RELA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5970
GTEX Portal (Tissue expression)RELA
Human Protein AtlasENSG00000173039-RELA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04206   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04206  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04206
PhosPhoSitePlusQ04206
Domaine pattern : Prosite (Expaxy)REL_1 (PS01204)    REL_2 (PS50254)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT_dom    IPT_NFkappaB    NFkB/Dor    p53-like_TF_DNA-bd    RelA    RHD_CS    RHD_dimer    RHD_DNA_bind_dom    RHD_DNA_bind_dom_sf   
Domain families : Pfam (Sanger)RHD_dimer (PF16179)    RHD_DNA_bind (PF00554)   
Domain families : Pfam (NCBI)pfam16179    pfam00554   
Domain families : Smart (EMBL)IPT (SM00429)  
Conserved Domain (NCBI)RELA
PDB (RSDB)1NFI    2LSP    2O61    3GUT    3QXY    3RC0    4KV1    4KV4    5U4K    5URN    6NV2    6QHL    6QHM    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2   
PDB Europe1NFI    2LSP    2O61    3GUT    3QXY    3RC0    4KV1    4KV4    5U4K    5URN    6NV2    6QHL    6QHM    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2   
PDB (PDBSum)1NFI    2LSP    2O61    3GUT    3QXY    3RC0    4KV1    4KV4    5U4K    5URN    6NV2    6QHL    6QHM    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2   
PDB (IMB)1NFI    2LSP    2O61    3GUT    3QXY    3RC0    4KV1    4KV4    5U4K    5URN    6NV2    6QHL    6QHM    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2   
Structural Biology KnowledgeBase1NFI    2LSP    2O61    3GUT    3QXY    3RC0    4KV1    4KV4    5U4K    5URN    6NV2    6QHL    6QHM    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2   
SCOP (Structural Classification of Proteins)1NFI    2LSP    2O61    3GUT    3QXY    3RC0    4KV1    4KV4    5U4K    5URN    6NV2    6QHL    6QHM    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2   
CATH (Classification of proteins structures)1NFI    2LSP    2O61    3GUT    3QXY    3RC0    4KV1    4KV4    5U4K    5URN    6NV2    6QHL    6QHM    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2   
SuperfamilyQ04206
AlphaFold pdb e-kbQ04206   
Human Protein Atlas [tissue]ENSG00000173039-RELA [tissue]
HPRD01241
Protein Interaction databases
DIP (DOE-UCLA)Q04206
IntAct (EBI)Q04206
Complex Portal (EBI)Q04206 CPX-5829 NF-kappaB DNA-binding transcription factor complex, p52/p65
Q04206 CPX-5834 NF-kappaB DNA-binding transcription factor complex, p65/c-Rel
Q04206 CPX-5835 NF-kappaB DNA-binding transcription factor complex, p65/p65
Q04206 CPX-5835 NF-kappaB DNA-binding transcription factor complex, p65/p65
Q04206 CPX-5828 NF-kappaB DNA-binding transcription factor complex, p50/p65
BioGRIDRELA
STRING (EMBL)RELA
ZODIACRELA
Ontologies - Pathways
QuickGOQ04206
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  chromatin  chromatin  chromatin  transcription cis-regulatory region binding  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription coactivator binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  liver development  hair follicle development  stimulatory C-type lectin receptor signaling pathway  DNA binding  DNA binding  chromatin binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  transcription regulator complex  nucleolus  cytoplasm  cytoplasm  cytosol  cytosol  acetaldehyde metabolic process  chromatin organization  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  inflammatory response  inflammatory response  cellular defense response  I-kappaB kinase/NF-kappaB signaling  aging  positive regulation of cell population proliferation  animal organ morphogenesis  response to organic substance  response to UV-B  positive regulation of Schwann cell differentiation  cytokine-mediated signaling pathway  enzyme binding  protein kinase binding  membrane protein intracellular domain proteolysis  chromatin DNA binding  ubiquitin protein ligase binding  positive regulation of type I interferon production  response to muramyl dipeptide  response to progesterone  positive regulation of interleukin-12 production  positive regulation of interleukin-8 production  response to insulin  tumor necrosis factor-mediated signaling pathway  negative regulation of protein sumoylation  cellular response to stress  response to cobalamin  response to cytokine  NF-kappaB p50/p65 complex  cellular response to hepatocyte growth factor stimulus  cellular response to vascular endothelial growth factor stimulus  response to muscle stretch  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  negative regulation of protein catabolic process  peptide binding  phosphate ion binding  response to drug  identical protein binding  identical protein binding  protein homodimerization activity  actinin binding  histone deacetylase binding  negative regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to amino acid  response to morphine  regulation of DNA-templated transcription in response to stress  protein-containing complex binding  innate immune response  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  negative regulation of insulin receptor signaling pathway  protein N-terminus binding  regulation of inflammatory response  T cell receptor signaling pathway  positive regulation of T cell receptor signaling pathway  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  response to cAMP  defense response to virus  regulation of transcription initiation from RNA polymerase II promoter  cellular response to hydrogen peroxide  nucleotide-binding oligomerization domain containing 2 signaling pathway  interleukin-1-mediated signaling pathway  interleukin-1-mediated signaling pathway  response to interleukin-1  cellular response to lipopolysaccharide  cellular response to lipoteichoic acid  cellular response to peptidoglycan  cellular response to nicotine  cellular response to interleukin-1  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  ankyrin repeat binding  glutamatergic synapse  postsynapse to nucleus signaling pathway  general transcription initiation factor binding  DNA-binding transcription factor binding  regulation of NIK/NF-kappaB signaling  negative regulation of NIK/NF-kappaB signaling  positive regulation of NIK/NF-kappaB signaling  positive regulation of NIK/NF-kappaB signaling  positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus  positive regulation of amyloid-beta formation  negative regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of pri-miRNA transcription by RNA polymerase II  cellular response to angiotensin  positive regulation of leukocyte adhesion to vascular endothelial cell  positive regulation of miRNA metabolic process  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  chromatin  chromatin  chromatin  transcription cis-regulatory region binding  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription coactivator binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  liver development  hair follicle development  stimulatory C-type lectin receptor signaling pathway  DNA binding  DNA binding  chromatin binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  transcription regulator complex  nucleolus  cytoplasm  cytoplasm  cytosol  cytosol  acetaldehyde metabolic process  chromatin organization  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  inflammatory response  inflammatory response  cellular defense response  I-kappaB kinase/NF-kappaB signaling  aging  positive regulation of cell population proliferation  animal organ morphogenesis  response to organic substance  response to UV-B  positive regulation of Schwann cell differentiation  cytokine-mediated signaling pathway  enzyme binding  protein kinase binding  membrane protein intracellular domain proteolysis  chromatin DNA binding  ubiquitin protein ligase binding  positive regulation of type I interferon production  response to muramyl dipeptide  response to progesterone  positive regulation of interleukin-12 production  positive regulation of interleukin-8 production  response to insulin  tumor necrosis factor-mediated signaling pathway  negative regulation of protein sumoylation  cellular response to stress  response to cobalamin  response to cytokine  NF-kappaB p50/p65 complex  cellular response to hepatocyte growth factor stimulus  cellular response to vascular endothelial growth factor stimulus  response to muscle stretch  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  negative regulation of protein catabolic process  peptide binding  phosphate ion binding  response to drug  identical protein binding  identical protein binding  protein homodimerization activity  actinin binding  histone deacetylase binding  negative regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to amino acid  response to morphine  regulation of DNA-templated transcription in response to stress  protein-containing complex binding  innate immune response  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  negative regulation of insulin receptor signaling pathway  protein N-terminus binding  regulation of inflammatory response  T cell receptor signaling pathway  positive regulation of T cell receptor signaling pathway  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  response to cAMP  defense response to virus  regulation of transcription initiation from RNA polymerase II promoter  cellular response to hydrogen peroxide  nucleotide-binding oligomerization domain containing 2 signaling pathway  interleukin-1-mediated signaling pathway  interleukin-1-mediated signaling pathway  response to interleukin-1  cellular response to lipopolysaccharide  cellular response to lipoteichoic acid  cellular response to peptidoglycan  cellular response to nicotine  cellular response to interleukin-1  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  ankyrin repeat binding  glutamatergic synapse  postsynapse to nucleus signaling pathway  general transcription initiation factor binding  DNA-binding transcription factor binding  regulation of NIK/NF-kappaB signaling  negative regulation of NIK/NF-kappaB signaling  positive regulation of NIK/NF-kappaB signaling  positive regulation of NIK/NF-kappaB signaling  positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus  positive regulation of amyloid-beta formation  negative regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of pri-miRNA transcription by RNA polymerase II  cellular response to angiotensin  positive regulation of leukocyte adhesion to vascular endothelial cell  positive regulation of miRNA metabolic process  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTACD40L Signaling Pathway [Genes]    Human Cytomegalovirus and Map Kinase Pathways [Genes]    Ceramide Signaling Pathway [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Ras Signaling Pathway [Genes]    Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]    NFkB activation by Nontypeable Hemophilus influenzae [Genes]    Cadmium induces DNA synthesis and proliferation in macrophages [Genes]    Keratinocyte Differentiation [Genes]    Activation of PKC through G protein coupled receptor [Genes]    TNFR2 Signaling Pathway [Genes]    NF-kB Signaling Pathway [Genes]    ATM Signaling Pathway [Genes]    Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]    MAPKinase Signaling Pathway [Genes]    Toll-Like Receptor Pathway [Genes]    Acetylation and Deacetylation of RelA in The Nucleus [Genes]    The 4-1BB-dependent immune response [Genes]    Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]    CXCR4 Signaling Pathway [Genes]    Corticosteroids and cardioprotection [Genes]    TACI and BCMA stimulation of B cell immune responses. [Genes]    Chaperones modulate interferon Signaling Pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages [Genes]    Signal transduction through IL1R [Genes]    The information-processing pathway at the IFN-beta enhancer [Genes]    Double Stranded RNA Induced Gene Expression [Genes]    TNF/Stress Related Signaling [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    Free Radical Induced Apoptosis [Genes]    Bone Remodelling [Genes]    T Cell Receptor Signaling Pathway [Genes]    AKT Signaling Pathway [Genes]    Influence of Ras and Rho proteins on G1 to S Transition [Genes]    Erythropoietin mediated neuroprotection through NF-kB [Genes]   
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Chemokine signaling pathway    NF-kappa B signaling pathway    HIF-1 signaling pathway    PI3K-Akt signaling pathway    Apoptosis    Osteoclast differentiation    Toll-like receptor signaling pathway    NOD-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    T cell receptor signaling pathway    B cell receptor signaling pathway    TNF signaling pathway    Neurotrophin signaling pathway    Prolactin signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Cocaine addiction    Epithelial cell signaling in Helicobacter pylori infection    Shigellosis    Salmonella infection    Pertussis    Legionellosis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Amoebiasis    Tuberculosis    Hepatitis C    Hepatitis B    Measles    Influenza A    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Transcriptional misregulation in cancer    Viral carcinogenesis    Pancreatic cancer    Prostate cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Small cell lung cancer    Inflammatory bowel disease (IBD)   
REACTOMEQ04206 [protein]
REACTOME PathwaysR-HSA-933542 [pathway]   
NDEx NetworkRELA
Atlas of Cancer Signalling NetworkRELA
Wikipedia pathwaysRELA
Orthology - Evolution
OrthoDB5970
GeneTree (enSembl)ENSG00000173039
Phylogenetic Trees/Animal Genes : TreeFamRELA
Homologs : HomoloGeneRELA
Homology/Alignments : Family Browser (UCSC)RELA
Gene fusions - Rearrangements
Fusion : MitelmanC11orf95::RELA [11q13.1/11q13.1]  
Fusion : MitelmanZMYND8::RELA [20q13.12/11q13.1]  
Fusion : QuiverRELA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRELA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RELA
dbVarRELA
ClinVarRELA
MonarchRELA
1000_GenomesRELA 
Exome Variant ServerRELA
GNOMAD BrowserENSG00000173039
Varsome BrowserRELA
ACMGRELA variants
VarityQ04206
Genomic Variants (DGV)RELA [DGVbeta]
DECIPHERRELA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRELA 
Mutations
ICGC Data PortalRELA 
TCGA Data PortalRELA 
Broad Tumor PortalRELA
OASIS PortalRELA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRELA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRELA
Mutations and Diseases : HGMDRELA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRELA
DgiDB (Drug Gene Interaction Database)RELA
DoCM (Curated mutations)RELA
CIViC (Clinical Interpretations of Variants in Cancer)RELA
NCG (London)RELA
Cancer3DRELA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164014    618287   
Orphanet19666   
DisGeNETRELA
MedgenRELA
Genetic Testing Registry RELA
NextProtQ04206 [Medical]
GENETestsRELA
Target ValidationRELA
Huge Navigator RELA [HugePedia]
ClinGenRELA
Clinical trials, drugs, therapy
MyCancerGenomeRELA
Protein Interactions : CTDRELA
Pharm GKB GenePA296
Pharm GKB PathwaysPA162356267   PA165985892   
PharosQ04206
Clinical trialRELA
Miscellaneous
canSAR (ICR)RELA
HarmonizomeRELA
DataMed IndexRELA
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRELA
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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