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RELB (v-rel reticuloendotheliosis viral oncogene homolog B)

Written2002-01Fei Chen
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

(Note : for Links provided by Atlas : click)

Identity

Alias_namesv-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Alias_symbol (synonym)REL-B
Other aliasI-Rel
HGNC (Hugo) RELB
LocusID (NCBI) 5971
Atlas_Id 324
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 45001449 and ends at 45038198 bp from pter ( according to hg19-Feb_2009)  [Mapping RELB.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLASRP (19q13.32) / RELB (19q13.32)PEPD (19q13.11) / RELB (19q13.32)RELB (19q13.32) / IGSF23 (19q13.31)
RELB (19q13.32) / NECTIN2 (19q13.32)RELB (19q13.32) / SMIM14 (4p14)RFX3 (9p24.2) / RELB (19q13.32)
Note see also, in the Deep Insight section: Upstream Signal Transduction of NF-kB Activation

DNA/RNA

Description The gene encoding human RelB has 11 exons spanning ~ 37 kb. Analysis of the 5'-flanking region of human relb gene indicates that RelB transcription is dependent on a TATA-less promoter containing two kB sites. Thus, while relA is constitutively expressed, the expression of both rel and relb is in an inducible fashion and dependent on NF-kB.

Protein

Description The human relb gene encodes a protein composed 579 amino acids with an approximately molecular weight of 66 kDa. Although structurally similar with other Rel family proteins containing RHD, NLS and TA domain, RelB contains an additional 121 amino acid region located at the N-terminus of RHD. Original study indicated that RelB failed to associate with RelA(p65) and to interact with DNA. That is the reason why it was named as inhibitive-Rel (I-Rel). In contrast, later studies demonstrated that RelB was able to form a heterodimer with NF-kB p50 or p52 and induce the transcription of target constructs or genes. No DNA binding activity has been suggested for the homodimeric complex of RelB, which may be possibly due to the N-terminal 121 amino acid domain that interfered with the DNA binding of RHD.
Expression wide.
Localisation cytosol, nuclei after activation.
Function regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. Interaction with: members of IkB family and Rel family.

Implicated in

Note
  
Entity cancer, autoimmune arthritis, glomerulonephritis, asthma, inflammatory bowel disease, septic shock, lung fibrosis, HTLV-1 infection, and AIDS.
  

Bibliography

The NF-kappa B and I kappa B proteins: new discoveries and insights.
Baldwin AS Jr
Annual review of immunology. 1996 ; 14 : 649-683.
PMID 8717528
 
Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins.
Bours V, Azarenko V, Dejardin E, Siebenlist U
Oncogene. 1994 ; 9 (6) : 1699-1702.
PMID 8183565
 
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.
Ghosh S, May MJ, Kopp EB
Annual review of immunology. 1998 ; 16 : 225-260.
PMID 9597130
 
I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.
Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA
Genes & development. 1992 ; 6 (5) : 745-760.
PMID 1577270
 

Citation

This paper should be referenced as such :
Chen, F
RELB (v-rel reticuloendotheliosis viral oncogene homolog B)
Atlas Genet Cytogenet Oncol Haematol. 2002;6(2):102-103.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/RELBID324.html


External links

Nomenclature
HGNC (Hugo)RELB   9956
Cards
AtlasRELBID324
Entrez_Gene (NCBI)RELB  5971  RELB proto-oncogene, NF-kB subunit
AliasesI-REL; IREL; REL-B
GeneCards (Weizmann)RELB
Ensembl hg19 (Hinxton)ENSG00000104856 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104856 [Gene_View]  chr19:45001449-45038198 [Contig_View]  RELB [Vega]
ICGC DataPortalENSG00000104856
TCGA cBioPortalRELB
AceView (NCBI)RELB
Genatlas (Paris)RELB
WikiGenes5971
SOURCE (Princeton)RELB
Genetics Home Reference (NIH)RELB
Genomic and cartography
GoldenPath hg38 (UCSC)RELB  -     chr19:45001449-45038198 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RELB  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblRELB - 19q13.32 [CytoView hg19]  RELB - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBIRELB [Mapview hg19]  RELB [Mapview hg38]
OMIM604758   
Gene and transcription
Genbank (Entrez)AK290594 AL583128 AW137991 BC028013 BI906507
RefSeq transcript (Entrez)NM_006509
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RELB
Cluster EST : UnigeneHs.654402 [ NCBI ]
CGAP (NCI)Hs.654402
Alternative Splicing GalleryENSG00000104856
Gene ExpressionRELB [ NCBI-GEO ]   RELB [ EBI - ARRAY_EXPRESS ]   RELB [ SEEK ]   RELB [ MEM ]
Gene Expression Viewer (FireBrowse)RELB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5971
GTEX Portal (Tissue expression)RELB
Human Protein AtlasENSG00000104856-RELB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01201   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01201  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01201
Splice isoforms : SwissVarQ01201
PhosPhoSitePlusQ01201
Domaine pattern : Prosite (Expaxy)REL_1 (PS01204)    REL_2 (PS50254)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT    IPT_NFkappaB    NFkB/Dor    p53-like_TF_DNA-bd    RelB    RelB_leu_zip    RelB_transact    RHD_CS    RHD_dimer    RHD_DNA_bind_dom   
Domain families : Pfam (Sanger)RelB_leu_zip (PF16180)    RelB_transactiv (PF16181)    RHD_dimer (PF16179)    RHD_DNA_bind (PF00554)   
Domain families : Pfam (NCBI)pfam16180    pfam16181    pfam16179    pfam00554   
Domain families : Smart (EMBL)IPT (SM00429)  
Conserved Domain (NCBI)RELB
DMDM Disease mutations5971
Blocks (Seattle)RELB
SuperfamilyQ01201
Human Protein Atlas [tissue]ENSG00000104856-RELB [tissue]
Peptide AtlasQ01201
HPRD06886
IPIIPI00221034   IPI00967958   IPI00967948   
Protein Interaction databases
DIP (DOE-UCLA)Q01201
IntAct (EBI)Q01201
FunCoupENSG00000104856
BioGRIDRELB
STRING (EMBL)RELB
ZODIACRELB
Ontologies - Pathways
QuickGOQ01201
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  core promoter binding  stimulatory C-type lectin receptor signaling pathway  chromatin binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  microtubule organizing center  cytosol  cytosol  cytosol  transcription, DNA-templated  inflammatory response  I-kappaB kinase/NF-kappaB signaling  antigen processing and presentation  negative regulation of interferon-beta production  circadian regulation of gene expression  I-kappaB/NF-kappaB complex  response to cytokine  NIK/NF-kappaB signaling  NIK/NF-kappaB signaling  myeloid dendritic cell differentiation  T-helper 1 cell differentiation  innate immune response  positive regulation of transcription from RNA polymerase II promoter  cellular response to osmotic stress  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  core promoter binding  stimulatory C-type lectin receptor signaling pathway  chromatin binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  microtubule organizing center  cytosol  cytosol  cytosol  transcription, DNA-templated  inflammatory response  I-kappaB kinase/NF-kappaB signaling  antigen processing and presentation  negative regulation of interferon-beta production  circadian regulation of gene expression  I-kappaB/NF-kappaB complex  response to cytokine  NIK/NF-kappaB signaling  NIK/NF-kappaB signaling  myeloid dendritic cell differentiation  T-helper 1 cell differentiation  innate immune response  positive regulation of transcription from RNA polymerase II promoter  cellular response to osmotic stress  
Pathways : KEGGMAPK signaling pathway    NF-kappa B signaling pathway    Osteoclast differentiation    HTLV-I infection    Epstein-Barr virus infection   
REACTOMEQ01201 [protein]
REACTOME PathwaysR-HSA-5676590 [pathway]   
NDEx NetworkRELB
Atlas of Cancer Signalling NetworkRELB
Wikipedia pathwaysRELB
Orthology - Evolution
OrthoDB5971
GeneTree (enSembl)ENSG00000104856
Phylogenetic Trees/Animal Genes : TreeFamRELB
HOVERGENQ01201
HOGENOMQ01201
Homologs : HomoloGeneRELB
Homology/Alignments : Family Browser (UCSC)RELB
Gene fusions - Rearrangements
Fusion : MitelmanCLASRP/RELB [19q13.32/19q13.32]  [t(19;19)(q13;q13)]  
Fusion : MitelmanRELB/IGSF23 [19q13.32/19q13.31]  [t(19;19)(q13;q13)]  
Fusion : MitelmanRFX3/RELB [9p24.2/19q13.32]  [t(9;19)(p24;q13)]  
Fusion: TCGACLASRP 19q13.32 RELB 19q13.32 BRCA
Fusion: TCGARELB 19q13.32 IGSF23 19q13.31 LUAD
Fusion: TCGARFX3 9p24.2 RELB 19q13.32 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRELB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RELB
dbVarRELB
ClinVarRELB
1000_GenomesRELB 
Exome Variant ServerRELB
ExAC (Exome Aggregation Consortium)ENSG00000104856
GNOMAD BrowserENSG00000104856
Genetic variants : HAPMAP5971
Genomic Variants (DGV)RELB [DGVbeta]
DECIPHERRELB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRELB 
Mutations
ICGC Data PortalRELB 
TCGA Data PortalRELB 
Broad Tumor PortalRELB
OASIS PortalRELB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRELB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRELB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RELB
DgiDB (Drug Gene Interaction Database)RELB
DoCM (Curated mutations)RELB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RELB (select a term)
intoGenRELB
NCG5 (London)RELB
Cancer3DRELB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604758   
Orphanet
MedgenRELB
Genetic Testing Registry RELB
NextProtQ01201 [Medical]
TSGene5971
GENETestsRELB
Target ValidationRELB
Huge Navigator RELB [HugePedia]
snp3D : Map Gene to Disease5971
BioCentury BCIQRELB
ClinGenRELB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5971
Chemical/Pharm GKB GenePA34322
Clinical trialRELB
Miscellaneous
canSAR (ICR)RELB (select the gene name)
Probes
Litterature
PubMed159 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRELB
EVEXRELB
GoPubMedRELB
iHOPRELB
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Oct 12 16:32:22 CEST 2017

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