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RELN (reelin)

Identity

Alias_symbol (synonym)RL
PRO1598
HGNC (Hugo) RELN
LocusID (NCBI) 5649
Atlas_Id 46196
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 103112231 and ends at 103629963 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RELN   9957
Cards
Entrez_Gene (NCBI)RELN  5649  reelin
AliasesETL7; LIS2; PRO1598; RL
GeneCards (Weizmann)RELN
Ensembl hg19 (Hinxton)ENSG00000189056 [Gene_View]  chr7:103112231-103629963 [Contig_View]  RELN [Vega]
Ensembl hg38 (Hinxton)ENSG00000189056 [Gene_View]  chr7:103112231-103629963 [Contig_View]  RELN [Vega]
ICGC DataPortalENSG00000189056
TCGA cBioPortalRELN
AceView (NCBI)RELN
Genatlas (Paris)RELN
WikiGenes5649
SOURCE (Princeton)RELN
Genetics Home Reference (NIH)RELN
Genomic and cartography
GoldenPath hg19 (UCSC)RELN  -     chr7:103112231-103629963 -  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RELN  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblRELN - 7q22.1 [CytoView hg19]  RELN - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIRELN [Mapview hg19]  RELN [Mapview hg38]
OMIM257320   600512   600514   616436   
Gene and transcription
Genbank (Entrez)AK093843 AK293863 AK297459 AY927583 BC172269
RefSeq transcript (Entrez)NM_005045 NM_173054
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_011877 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)RELN
Cluster EST : UnigeneHs.655654 [ NCBI ]
CGAP (NCI)Hs.655654
Alternative Splicing GalleryENSG00000189056
Gene ExpressionRELN [ NCBI-GEO ]   RELN [ EBI - ARRAY_EXPRESS ]   RELN [ SEEK ]   RELN [ MEM ]
Gene Expression Viewer (FireBrowse)RELN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5649
GTEX Portal (Tissue expression)RELN
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78509   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78509  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78509
Splice isoforms : SwissVarP78509
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusP78509
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    REELIN (PS51019)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    Reeler_dom    Sialidases   
Domain families : Pfam (Sanger)Reeler (PF02014)   
Domain families : Pfam (NCBI)pfam02014   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)RELN
DMDM Disease mutations5649
Blocks (Seattle)RELN
SuperfamilyP78509
Human Protein AtlasENSG00000189056
Peptide AtlasP78509
HPRD02742
IPIIPI00294776   IPI00241562   IPI00847589   IPI00966229   IPI01009607   IPI00921481   IPI00927668   
Protein Interaction databases
DIP (DOE-UCLA)P78509
IntAct (EBI)P78509
FunCoupENSG00000189056
BioGRIDRELN
STRING (EMBL)RELN
ZODIACRELN
Ontologies - Pathways
QuickGOP78509
Ontology : AmiGOcell morphogenesis involved in differentiation  neuron migration  protein serine/threonine/tyrosine kinase activity  proteinaceous extracellular matrix  extracellular space  cytoplasm  plasma membrane  proteolysis  cell adhesion  axon guidance  central nervous system development  brain development  long-term memory  serine-type peptidase activity  associative learning  glial cell differentiation  positive regulation of neuron projection development  positive regulation of phosphatidylinositol 3-kinase signaling  dendrite development  peptidyl-tyrosine phosphorylation  spinal cord patterning  ventral spinal cord development  hippocampus development  cerebral cortex tangential migration  layer formation in cerebral cortex  dendrite  positive regulation of TOR signaling  positive regulation of CREB transcription factor activity  reelin-mediated signaling pathway  positive regulation of protein kinase activity  metal ion binding  response to pain  positive regulation of peptidyl-tyrosine phosphorylation  regulation of behavior  modulation of synaptic transmission  positive regulation of small GTPase mediated signal transduction  positive regulation of synaptic transmission, glutamatergic  long-term synaptic potentiation  positive regulation of dendritic spine morphogenesis  positive regulation of protein tyrosine kinase activity  lipoprotein particle receptor binding  very-low-density lipoprotein particle receptor binding  positive regulation of synapse maturation  NMDA glutamate receptor clustering  postsynaptic density protein 95 clustering  receptor localization to synapse  lateral motor column neuron migration  positive regulation of long-term synaptic potentiation  positive regulation of lateral motor column neuron migration  regulation of N-methyl-D-aspartate selective glutamate receptor activity  positive regulation of excitatory postsynaptic potential  positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity  
Ontology : EGO-EBIcell morphogenesis involved in differentiation  neuron migration  protein serine/threonine/tyrosine kinase activity  proteinaceous extracellular matrix  extracellular space  cytoplasm  plasma membrane  proteolysis  cell adhesion  axon guidance  central nervous system development  brain development  long-term memory  serine-type peptidase activity  associative learning  glial cell differentiation  positive regulation of neuron projection development  positive regulation of phosphatidylinositol 3-kinase signaling  dendrite development  peptidyl-tyrosine phosphorylation  spinal cord patterning  ventral spinal cord development  hippocampus development  cerebral cortex tangential migration  layer formation in cerebral cortex  dendrite  positive regulation of TOR signaling  positive regulation of CREB transcription factor activity  reelin-mediated signaling pathway  positive regulation of protein kinase activity  metal ion binding  response to pain  positive regulation of peptidyl-tyrosine phosphorylation  regulation of behavior  modulation of synaptic transmission  positive regulation of small GTPase mediated signal transduction  positive regulation of synaptic transmission, glutamatergic  long-term synaptic potentiation  positive regulation of dendritic spine morphogenesis  positive regulation of protein tyrosine kinase activity  lipoprotein particle receptor binding  very-low-density lipoprotein particle receptor binding  positive regulation of synapse maturation  NMDA glutamate receptor clustering  postsynaptic density protein 95 clustering  receptor localization to synapse  lateral motor column neuron migration  positive regulation of long-term synaptic potentiation  positive regulation of lateral motor column neuron migration  regulation of N-methyl-D-aspartate selective glutamate receptor activity  positive regulation of excitatory postsynaptic potential  positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity  
Pathways : BIOCARTAReelin Signaling Pathway [Genes]    Lissencephaly gene (LIS1) in neuronal migration and development [Genes]   
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction   
NDEx NetworkRELN
Atlas of Cancer Signalling NetworkRELN
Wikipedia pathwaysRELN
Orthology - Evolution
OrthoDB5649
GeneTree (enSembl)ENSG00000189056
Phylogenetic Trees/Animal Genes : TreeFamRELN
HOVERGENP78509
HOGENOMP78509
Homologs : HomoloGeneRELN
Homology/Alignments : Family Browser (UCSC)RELN
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRELN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RELN
dbVarRELN
ClinVarRELN
1000_GenomesRELN 
Exome Variant ServerRELN
ExAC (Exome Aggregation Consortium)RELN (select the gene name)
Genetic variants : HAPMAP5649
Genomic Variants (DGV)RELN [DGVbeta]
DECIPHER (Syndromes)7:103112231-103629963  ENSG00000189056
CONAN: Copy Number AnalysisRELN 
Mutations
ICGC Data PortalRELN 
TCGA Data PortalRELN 
Broad Tumor PortalRELN
OASIS PortalRELN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRELN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRELN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RELN
DgiDB (Drug Gene Interaction Database)RELN
DoCM (Curated mutations)RELN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RELN (select a term)
intoGenRELN
Cancer3DRELN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM257320    600512    600514    616436   
Orphanet11909    14757   
MedgenRELN
Genetic Testing Registry RELN
NextProtP78509 [Medical]
TSGene5649
GENETestsRELN
Huge Navigator RELN [HugePedia]
snp3D : Map Gene to Disease5649
BioCentury BCIQRELN
ClinGenRELN (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5649
Chemical/Pharm GKB GenePA34323
Clinical trialRELN
Miscellaneous
canSAR (ICR)RELN (select the gene name)
Probes
Litterature
PubMed159 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRELN
EVEXRELN
GoPubMedRELN
iHOPRELN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:49:44 CET 2016

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