RELN (reelin)

2007-02-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
ETL7,LIS2,PRO1598,RL

Other Information

Locus ID:

NCBI: 5649
MIM: 600514
HGNC: 9957
Ensembl: ENSG00000189056

Variants:

dbSNP: 5649
ClinVar: 5649
TCGA: ENSG00000189056
COSMIC: RELN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189056ENST00000343529P78509
ENSG00000189056ENST00000424685J3KQ66
ENSG00000189056ENST00000428762P78509
ENSG00000189056ENST00000429186H7C2B0

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
VLDL interactionsREACTOMER-HSA-8855121
Reelin signalling pathwayREACTOMER-HSA-8866376

References

Pubmed IDYearTitleCitations
159615432005Reelin promoter hypermethylation in schizophrenia.175
213152592011Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex.144
182821072008Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women.117
182821072008Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women.117
123765332002Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta.102
113172162001Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder.82
158202352005Reelin signaling is impaired in autism.63
165104952006Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
129312092003Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis.61

Citation

Dessen P

RELN (reelin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46196/reln