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RELN (reelin)

Identity

Other namesLIS2
PRO1598
RL
HGNC (Hugo) RELN
LocusID (NCBI) 5649
Atlas_Id 46196
Location 7q22.1
Location_base_pair Starts at 103112231 and ends at 103629963 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RELN   9957
Cards
Entrez_Gene (NCBI)RELN  5649  reelin
GeneCards (Weizmann)RELN
Ensembl hg19 (Hinxton)ENSG00000189056 [Gene_View]  chr7:103112231-103629963 [Contig_View]  RELN [Vega]
Ensembl hg38 (Hinxton)ENSG00000189056 [Gene_View]  chr7:103112231-103629963 [Contig_View]  RELN [Vega]
ICGC DataPortalENSG00000189056
TCGA cBioPortalRELN
AceView (NCBI)RELN
Genatlas (Paris)RELN
WikiGenes5649
SOURCE (Princeton)RELN
Genomic and cartography
GoldenPath hg19 (UCSC)RELN  -     chr7:103112231-103629963 -  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RELN  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblRELN - 7q22.1 [CytoView hg19]  RELN - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIRELN [Mapview hg19]  RELN [Mapview hg38]
OMIM257320   600514   
Gene and transcription
Genbank (Entrez)AK093843 AK293863 AK297459 AY927583 BC172269
RefSeq transcript (Entrez)NM_005045 NM_173054
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_011877 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)RELN
Cluster EST : UnigeneHs.655654 [ NCBI ]
CGAP (NCI)Hs.655654
Alternative Splicing : Fast-db (Paris)GSHG0028455
Alternative Splicing GalleryENSG00000189056
Gene ExpressionRELN [ NCBI-GEO ]     RELN [ SEEK ]   RELN [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78509 (Uniprot)
NextProtP78509  [Medical]  [Publications]
With graphics : InterProP78509
Splice isoforms : SwissVarP78509 (Swissvar)
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    REELIN (PS51019)   
Domains : Interpro (EBI)EG-like_dom    EGF-like_CS    Reeler_dom    Sialidases   
Related proteins : CluSTrP78509
Domain families : Pfam (Sanger)hEGF (PF12661)    Reeler (PF02014)   
Domain families : Pfam (NCBI)pfam12661    pfam02014   
Domain families : Smart (EMBL)EGF (SM00181)  
DMDM Disease mutations5649
Blocks (Seattle)P78509
Human Protein AtlasENSG00000189056
Peptide AtlasP78509
HPRD02742
IPIIPI00294776   IPI00241562   IPI00847589   IPI00966229   IPI01009607   IPI00921481   IPI00927668   
Protein Interaction databases
DIP (DOE-UCLA)P78509
IntAct (EBI)P78509
FunCoupENSG00000189056
BioGRIDRELN
IntegromeDBRELN
STRING (EMBL)RELN
Ontologies - Pathways
QuickGOP78509
Ontology : AmiGOcell morphogenesis involved in differentiation  neuron migration  protein serine/threonine/tyrosine kinase activity  proteinaceous extracellular matrix  extracellular space  cytoplasm  proteolysis  cell adhesion  axon guidance  central nervous system development  brain development  long-term memory  serine-type peptidase activity  associative learning  glial cell differentiation  positive regulation of neuron projection development  positive regulation of phosphatidylinositol 3-kinase signaling  dendrite development  peptidyl-tyrosine phosphorylation  spinal cord patterning  ventral spinal cord development  hippocampus development  cerebral cortex tangential migration  layer formation in cerebral cortex  dendrite  positive regulation of TOR signaling  positive regulation of CREB transcription factor activity  reelin-mediated signaling pathway  positive regulation of protein kinase activity  metal ion binding  response to pain  positive regulation of peptidyl-tyrosine phosphorylation  regulation of behavior  regulation of synaptic transmission  positive regulation of small GTPase mediated signal transduction  positive regulation of synaptic transmission, glutamatergic  positive regulation of dendritic spine morphogenesis  positive regulation of protein tyrosine kinase activity  lipoprotein particle receptor binding  very-low-density lipoprotein particle receptor binding  positive regulation of synapse maturation  N-methyl-D-aspartate receptor clustering  postsynaptic density protein 95 clustering  receptor localization to synapse  lateral motor column neuron migration  positive regulation of long-term synaptic potentiation  positive regulation of lateral motor column neuron migration  regulation of N-methyl-D-aspartate selective glutamate receptor activity  positive regulation of excitatory postsynaptic membrane potential  positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity  
Ontology : EGO-EBIcell morphogenesis involved in differentiation  neuron migration  protein serine/threonine/tyrosine kinase activity  proteinaceous extracellular matrix  extracellular space  cytoplasm  proteolysis  cell adhesion  axon guidance  central nervous system development  brain development  long-term memory  serine-type peptidase activity  associative learning  glial cell differentiation  positive regulation of neuron projection development  positive regulation of phosphatidylinositol 3-kinase signaling  dendrite development  peptidyl-tyrosine phosphorylation  spinal cord patterning  ventral spinal cord development  hippocampus development  cerebral cortex tangential migration  layer formation in cerebral cortex  dendrite  positive regulation of TOR signaling  positive regulation of CREB transcription factor activity  reelin-mediated signaling pathway  positive regulation of protein kinase activity  metal ion binding  response to pain  positive regulation of peptidyl-tyrosine phosphorylation  regulation of behavior  regulation of synaptic transmission  positive regulation of small GTPase mediated signal transduction  positive regulation of synaptic transmission, glutamatergic  positive regulation of dendritic spine morphogenesis  positive regulation of protein tyrosine kinase activity  lipoprotein particle receptor binding  very-low-density lipoprotein particle receptor binding  positive regulation of synapse maturation  N-methyl-D-aspartate receptor clustering  postsynaptic density protein 95 clustering  receptor localization to synapse  lateral motor column neuron migration  positive regulation of long-term synaptic potentiation  positive regulation of lateral motor column neuron migration  regulation of N-methyl-D-aspartate selective glutamate receptor activity  positive regulation of excitatory postsynaptic membrane potential  positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity  
Pathways : BIOCARTAReelin Signaling Pathway [Genes]    Lissencephaly gene (LIS1) in neuronal migration and development [Genes]   
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction   
Protein Interaction DatabaseRELN
DoCM (Curated mutations)RELN
Wikipedia pathwaysRELN
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerRELN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RELN
dbVarRELN
ClinVarRELN
1000_GenomesRELN 
Exome Variant ServerRELN
SNP (GeneSNP Utah)RELN
SNP : HGBaseRELN
Genetic variants : HAPMAPRELN
Genomic Variants (DGV)RELN [DGVbeta]
Mutations
ICGC Data PortalRELN 
TCGA Data PortalRELN 
Tumor PortalRELN
Somatic Mutations in Cancer : COSMICRELN 
LOVD (Leiden Open Variation Database)genes/RELN
LOVD (Leiden Open Variation Database)genes/RELN
LOVD (Leiden Open Variation Database)genes/RELN
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:103112231-103629963
CONAN: Copy Number AnalysisRELN 
Mutations and Diseases : HGMDRELN
OMIM257320    600514   
MedgenRELN
NextProtP78509 [Medical]
GENETestsRELN
Disease Genetic AssociationRELN
Huge Navigator RELN [HugePedia]  RELN [HugeCancerGEM]
snp3D : Map Gene to Disease5649
DGIdb (Drug Gene Interaction db)RELN
BioCentury BCIQRELN
General knowledge
Homologs : HomoloGeneRELN
Homology/Alignments : Family Browser (UCSC)RELN
Phylogenetic Trees/Animal Genes : TreeFamRELN
Chemical/Protein Interactions : CTD5649
Chemical/Pharm GKB GenePA34323
Clinical trialRELN
Cancer Resource (Charite)ENSG00000189056
Other databases
Probes
Litterature
PubMed148 Pubmed reference(s) in Entrez
CoreMineRELN
GoPubMedRELN
iHOPRELN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 29 19:14:24 CEST 2015

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