REM2 (RRAD and GEM like GTPase 2)

2006-10-01 Affiliation

Identity

HGNC

REM2

LOCATION

14q11.2

LOCUSID

161253

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 161253
MIM: 616955
HGNC: 20248
Ensembl: ENSG00000139890

Variants:

dbSNP: 161253
ClinVar: 161253
TCGA: ENSG00000139890
COSMIC: REM2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000139890	ENST00000267396	Q8IYK8
ENSG00000139890	ENST00000536884	Q8IYK8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
15728182	2005	Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.	44
20231315	2010	Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1.	39
21485012	2011	The GTPase Rem2 regulates synapse development and dendritic morphology.	24
29431731	2018	Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity.	10
22815963	2012	Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIα.	9
23991227	2013	A loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexity.	9
21980534	2011	Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents.	7
18056257	2008	An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19ARF expression that promotes endothelial cell proliferation and angiogenesis.	6
30072381	2018	The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity.	5

Citation

Dessen P

REM2 (RRAD and GEM like GTPase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43267/rem2