REPIN1 (replication initiator 1)

2014-03-01  

Identity

HGNC
REPIN1
LOCATION
7q36.1
LOCUSID
29803
ALIAS
AP4,RIP60,ZNF464,Zfp464
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29803
HGNC: 17922
Ensembl: ENSG00000214022

Variants:

dbSNP: 29803
ClinVar: 29803
TCGA: ENSG00000214022
COSMIC: REPIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000214022ENST00000397281Q9BWE0
ENSG00000214022ENST00000397281A0A090N8H1
ENSG00000214022ENST00000425389Q9BWE0
ENSG00000214022ENST00000425389A0A090N8H1
ENSG00000214022ENST00000444957Q9BWE0
ENSG00000214022ENST00000444957A0A090N8H1
ENSG00000214022ENST00000466559C9J0L4
ENSG00000214022ENST00000467980C9J7D4
ENSG00000214022ENST00000475514C9JZE3
ENSG00000214022ENST00000479668C9J590
ENSG00000214022ENST00000482680C9J590
ENSG00000214022ENST00000486714C9J7L2
ENSG00000214022ENST00000488943C9JYJ8
ENSG00000214022ENST00000489432Q9BWE0
ENSG00000214022ENST00000518514E5RK52
ENSG00000214022ENST00000519397E7EVL6
ENSG00000214022ENST00000522266C9J7D4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
242857252014p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer.47
169241112006A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells.36
207278512010Repin1 maybe involved in the regulation of cell size and glucose transport in adipocytes.6
260370742015AP4 activates cell migration and EMT mediated by p53 in MDA-MB-231 breast carcinoma cells.4
252668052015Crosstalk of AP4 and TGFβ receptor signaling in NSCLC.3
293374282018AP4 positively regulates LAPTM4B to promote hepatocellular carcinoma growth and metastasis, while reducing chemotherapy sensitivity.3
299153652019Metabolic effects of genetic variation in the human REPIN1 gene.3
299792592018Hsa-mir-127 impairs survival of patients with glioma and promotes proliferation, migration and invasion of cancerous cells by modulating replication initiator 1.2

Citation

Dessen P

REPIN1 (replication initiator 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53851/repin1