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RERE (arginine-glutamic acid dipeptide repeats)

Identity

Alias_namesATN1L
arginine-glutamic acid dipeptide (RE) repeats
Alias_symbol (synonym)KIAA0458
ARP
ARG
DNB1
Other aliasNEDBEH
HGNC (Hugo) RERE
LocusID (NCBI) 473
Atlas_Id 42083
Location 1p36.23  [Link to chromosome band 1p36]
Location_base_pair Starts at 8352404 and ends at 8817640 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP35 (19q13.32) / RERE (1p36.23)C4orf22 (4q21.21) / RERE (1p36.23)ETV6 (12p13.2) / RERE (1p36.23)
FARP1 (13q32.2) / RERE (1p36.23)RERE (1p36.23) / CYP4A11 (1p33)RERE (1p36.23) / GPR157 (1p36.23)
RERE (1p36.23) / LRMP (12p12.1)RERE (1p36.23) / PIK3CD (1p36.22)RERE (1p36.23) / PTGER3 (1p31.1)
RERE (1p36.23) / RERE (1p36.23)RERE (1p36.23) / SLC2A5 (1p36.23)RERE (1p36.23) / TTR (18q12.1)
RERE (1p36.23) / VAMP3 (1p36.23)RERE (1p36.23) / ZSWIM5 (1p34.1)U2AF2 (19q13.42) / RERE (1p36.23)
VPS13D (1p36.22) / RERE (1p36.23)ZFYVE21 (14q32.33) / RERE (1p36.23)RERE 1p36.23 / CYP4A11 1p33
RERE 1p36.23 / GPR157 1p36.23RERE 1p36.23 / SLC2A5 1p36.23RERE 1p36.23 / VAMP3 1p36.23
RERE 1p36.23 / ZSWIM5 1p34.1U2AF2 19q13.42 / RERE 1p36.23VPS13D 1p36.22 / RERE 1p36.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Prostate tumors: an overview
Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)RERE   9965
Cards
Entrez_Gene (NCBI)RERE  473  arginine-glutamic acid dipeptide repeats
AliasesARG; ARP; ATN1L; DNB1; 
NEDBEH
GeneCards (Weizmann)RERE
Ensembl hg19 (Hinxton)ENSG00000142599 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142599 [Gene_View]  chr1:8352404-8817640 [Contig_View]  RERE [Vega]
ICGC DataPortalENSG00000142599
TCGA cBioPortalRERE
AceView (NCBI)RERE
Genatlas (Paris)RERE
WikiGenes473
SOURCE (Princeton)RERE
Genetics Home Reference (NIH)RERE
Genomic and cartography
GoldenPath hg38 (UCSC)RERE  -     chr1:8352404-8817640 -  1p36.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RERE  -     1p36.23   [Description]    (hg19-Feb_2009)
EnsemblRERE - 1p36.23 [CytoView hg19]  RERE - 1p36.23 [CytoView hg38]
Mapping of homologs : NCBIRERE [Mapview hg19]  RERE [Mapview hg38]
OMIM605226   616975   
Gene and transcription
Genbank (Entrez)AB007927 AB036737 AF016005 AF118275 AK074834
RefSeq transcript (Entrez)NM_001042681 NM_001042682 NM_012102
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RERE
Cluster EST : UnigeneHs.463041 [ NCBI ]
CGAP (NCI)Hs.463041
Alternative Splicing GalleryENSG00000142599
Gene ExpressionRERE [ NCBI-GEO ]   RERE [ EBI - ARRAY_EXPRESS ]   RERE [ SEEK ]   RERE [ MEM ]
Gene Expression Viewer (FireBrowse)RERE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)473
GTEX Portal (Tissue expression)RERE
Human Protein AtlasENSG00000142599-RERE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2R6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2R6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2R6
Splice isoforms : SwissVarQ9P2R6
PhosPhoSitePlusQ9P2R6
Domaine pattern : Prosite (Expaxy)BAH (PS51038)    ELM2 (PS51156)    SANT (PS51293)   
Domains : Interpro (EBI)Atrophin-like    BAH_dom    ELM2_dom    Homeobox-like    SANT/Myb    SANT_dom    Znf_GATA    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Atrophin-1 (PF03154)    BAH (PF01426)    ELM2 (PF01448)    GATA (PF00320)   
Domain families : Pfam (NCBI)pfam03154    pfam01426    pfam01448    pfam00320   
Domain families : Smart (EMBL)BAH (SM00439)  ELM2 (SM01189)  SANT (SM00717)  ZnF_GATA (SM00401)  
Conserved Domain (NCBI)RERE
DMDM Disease mutations473
Blocks (Seattle)RERE
PDB (SRS)2YQK   
PDB (PDBSum)2YQK   
PDB (IMB)2YQK   
PDB (RSDB)2YQK   
Structural Biology KnowledgeBase2YQK   
SCOP (Structural Classification of Proteins)2YQK   
CATH (Classification of proteins structures)2YQK   
SuperfamilyQ9P2R6
Human Protein Atlas [tissue]ENSG00000142599-RERE [tissue]
Peptide AtlasQ9P2R6
HPRD05566
IPIIPI00185027   IPI01009383   IPI00479824   IPI00967727   IPI00966373   IPI00965380   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2R6
IntAct (EBI)Q9P2R6
FunCoupENSG00000142599
BioGRIDRERE
STRING (EMBL)RERE
ZODIACRERE
Ontologies - Pathways
QuickGOQ9P2R6
Ontology : AmiGOhistone deacetylase complex  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription coactivator activity  RNA polymerase II transcription corepressor activity  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  chromatin remodeling  transcription, DNA-templated  NLS-bearing protein import into nucleus  poly-glutamine tract binding  zinc ion binding  cerebellar Purkinje cell layer maturation  cerebellar granule cell precursor proliferation  radial glia guided migration of Purkinje cell  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  branching morphogenesis of a nerve  dendrite morphogenesis  
Ontology : EGO-EBIhistone deacetylase complex  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription coactivator activity  RNA polymerase II transcription corepressor activity  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  chromatin remodeling  transcription, DNA-templated  NLS-bearing protein import into nucleus  poly-glutamine tract binding  zinc ion binding  cerebellar Purkinje cell layer maturation  cerebellar granule cell precursor proliferation  radial glia guided migration of Purkinje cell  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  branching morphogenesis of a nerve  dendrite morphogenesis  
NDEx NetworkRERE
Atlas of Cancer Signalling NetworkRERE
Wikipedia pathwaysRERE
Orthology - Evolution
OrthoDB473
GeneTree (enSembl)ENSG00000142599
Phylogenetic Trees/Animal Genes : TreeFamRERE
HOVERGENQ9P2R6
HOGENOMQ9P2R6
Homologs : HomoloGeneRERE
Homology/Alignments : Family Browser (UCSC)RERE
Gene fusions - Rearrangements
Fusion : MitelmanC4orf22/RERE [4q21.21/1p36.23]  [t(1;4)(p36;q21)]  
Fusion : MitelmanRERE/CYP4A11 [1p36.23/1p33]  [t(1;1)(p33;p36)]  
Fusion : MitelmanRERE/GPR157 [1p36.23/1p36.23]  [t(1;1)(p36;p36)]  
Fusion : MitelmanRERE/PIK3CD [1p36.23/1p36.22]  [del(1)(p36p36)]  
Fusion : MitelmanRERE/SLC2A5 [1p36.23/1p36.23]  [t(1;1)(p36;p36)]  
Fusion : MitelmanRERE/VAMP3 [1p36.23/1p36.23]  [t(1;1)(p36;p36)]  
Fusion : MitelmanRERE/ZSWIM5 [1p36.23/1p34.1]  [t(1;1)(p34;p36)]  
Fusion : MitelmanU2AF2/RERE [19q13.42/1p36.23]  [t(1;19)(p36;q13)]  
Fusion : MitelmanVPS13D/RERE [1p36.22/1p36.23]  [t(1;1)(p36;p36)]  
Fusion: TCGARERE 1p36.23 CYP4A11 1p33 BRCA
Fusion: TCGARERE 1p36.23 GPR157 1p36.23 BRCA LUAD
Fusion: TCGARERE 1p36.23 SLC2A5 1p36.23 LUAD
Fusion: TCGARERE 1p36.23 VAMP3 1p36.23 LGG
Fusion: TCGARERE 1p36.23 ZSWIM5 1p34.1 BRCA
Fusion: TCGAU2AF2 19q13.42 RERE 1p36.23 BRCA
Fusion: TCGAVPS13D 1p36.22 RERE 1p36.23 BRCA
Fusion: Tumor Portal RERE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRERE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RERE
dbVarRERE
ClinVarRERE
1000_GenomesRERE 
Exome Variant ServerRERE
ExAC (Exome Aggregation Consortium)ENSG00000142599
GNOMAD BrowserENSG00000142599
Genetic variants : HAPMAP473
Genomic Variants (DGV)RERE [DGVbeta]
DECIPHERRERE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRERE 
Mutations
ICGC Data PortalRERE 
TCGA Data PortalRERE 
Broad Tumor PortalRERE
OASIS PortalRERE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRERE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRERE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RERE
DgiDB (Drug Gene Interaction Database)RERE
DoCM (Curated mutations)RERE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RERE (select a term)
intoGenRERE
Cancer3DRERE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605226    616975   
Orphanet
MedgenRERE
Genetic Testing Registry RERE
NextProtQ9P2R6 [Medical]
TSGene473
GENETestsRERE
Target ValidationRERE
Huge Navigator RERE [HugePedia]
snp3D : Map Gene to Disease473
BioCentury BCIQRERE
ClinGenRERE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD473
Chemical/Pharm GKB GenePA34332
Clinical trialRERE
Miscellaneous
canSAR (ICR)RERE (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRERE
EVEXRERE
GoPubMedRERE
iHOPRERE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:08:26 CET 2017

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