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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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REV3L (REV3-like, polymerase (DNA directed), zeta, catalytic subunit)

Identity

Other namesPOLZ
REV3
HGNC (Hugo) REV3L
LocusID (NCBI) 5980
Location 6q21
Location_base_pair Starts at 111620234 and ends at 111804918 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)REV3L   9968
Cards
Entrez_Gene (NCBI)REV3L  5980  REV3-like, polymerase (DNA directed), zeta, catalytic subunit
GeneCards (Weizmann)REV3L
Ensembl hg19 (Hinxton)ENSG00000009413 [Gene_View]  chr6:111620234-111804918 [Contig_View]  REV3L [Vega]
Ensembl hg38 (Hinxton)ENSG00000009413 [Gene_View]  chr6:111620234-111804918 [Contig_View]  REV3L [Vega]
ICGC DataPortalENSG00000009413
cBioPortalREV3L
AceView (NCBI)REV3L
Genatlas (Paris)REV3L
WikiGenes5980
SOURCE (Princeton)REV3L
Genomic and cartography
GoldenPath hg19 (UCSC)REV3L  -     chr6:111620234-111804918 -  6q21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)REV3L  -     6q21   [Description]    (hg38-Dec_2013)
EnsemblREV3L - 6q21 [CytoView hg19]  REV3L - 6q21 [CytoView hg38]
Mapping of homologs : NCBIREV3L [Mapview hg19]  REV3L [Mapview hg38]
OMIM602776   
Gene and transcription
Genbank (Entrez)AB209256 AF004713 AF035537 AF058701 AF071798
RefSeq transcript (Entrez)NM_001286431 NM_001286432 NM_002912
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_025741 NW_004929328
Consensus coding sequences : CCDS (NCBI)REV3L
Cluster EST : UnigeneHs.232021 [ NCBI ]
CGAP (NCI)Hs.232021
Alternative Splicing : Fast-db (Paris)GSHG0026841
Alternative Splicing GalleryENSG00000009413
Gene ExpressionREV3L [ NCBI-GEO ]     REV3L [ SEEK ]   REV3L [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60673 (Uniprot)
NextProtO60673  [Medical]
With graphics : InterProO60673
Splice isoforms : SwissVarO60673 (Swissvar)
Catalytic activity : Enzyme2.7.7.7 [ Enzyme-Expasy ]   2.7.7.72.7.7.7 [ IntEnz-EBI ]   2.7.7.7 [ BRENDA ]   2.7.7.7 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)DNA_POLYMERASE_B (PS00116)   
Domains : Interpro (EBI)DNA-dir_DNA_pol_B    DNA-dir_DNA_pol_B_CS    DNA-dir_DNA_pol_B_exonuc    DNA-dir_DNA_pol_B_multi_dom    DNA_pol_palm_dom    RNaseH-like_dom    Znf-C4pol   
Related proteins : CluSTrO60673
Domain families : Pfam (Sanger)DNA_pol_B (PF00136)    DNA_pol_B_exo1 (PF03104)    zf-C4pol (PF14260)   
Domain families : Pfam (NCBI)pfam00136    pfam03104    pfam14260   
Domain families : Smart (EMBL)POLBc (SM00486)  
DMDM Disease mutations5980
Blocks (Seattle)O60673
PDB (SRS)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
PDB (PDBSum)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
PDB (IMB)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
PDB (RSDB)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
Human Protein AtlasENSG00000009413
Peptide AtlasO60673
HPRD04145
IPIIPI00248651   IPI00745230   IPI01015656   IPI00827615   IPI00879141   IPI00855811   
Protein Interaction databases
DIP (DOE-UCLA)O60673
IntAct (EBI)O60673
FunCoupENSG00000009413
BioGRIDREV3L
IntegromeDBREV3L
STRING (EMBL)REV3L
Ontologies - Pathways
QuickGOO60673
Ontology : AmiGOnucleotide binding  DNA binding  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  nucleolus  DNA-dependent DNA replication  DNA repair  zeta DNA polymerase complex  error-prone translesion synthesis  metal ion binding  4 iron, 4 sulfur cluster binding  
Ontology : EGO-EBInucleotide binding  DNA binding  DNA-directed DNA polymerase activity  protein binding  nucleus  nucleoplasm  nucleolus  DNA-dependent DNA replication  DNA repair  zeta DNA polymerase complex  error-prone translesion synthesis  metal ion binding  4 iron, 4 sulfur cluster binding  
Pathways : KEGGFanconi anemia pathway   
Protein Interaction DatabaseREV3L
DoCM (Curated mutations)REV3L
Wikipedia pathwaysREV3L
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerREV3L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)REV3L
dbVarREV3L
ClinVarREV3L
1000_GenomesREV3L 
Exome Variant ServerREV3L
SNP (GeneSNP Utah)REV3L
SNP : HGBaseREV3L
Genetic variants : HAPMAPREV3L
Genomic Variants (DGV)REV3L [DGVbeta]
Mutations
ICGC Data PortalENSG00000009413 
Somatic Mutations in Cancer : COSMICREV3L 
CONAN: Copy Number AnalysisREV3L 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:111620234-111804918
Mutations and Diseases : HGMDREV3L
OMIM602776   
MedgenREV3L
NextProtO60673 [Medical]
GENETestsREV3L
Disease Genetic AssociationREV3L
Huge Navigator REV3L [HugePedia]  REV3L [HugeCancerGEM]
snp3D : Map Gene to Disease5980
DGIdb (Drug Gene Interaction db)REV3L
General knowledge
Homologs : HomoloGeneREV3L
Homology/Alignments : Family Browser (UCSC)REV3L
Phylogenetic Trees/Animal Genes : TreeFamREV3L
Chemical/Protein Interactions : CTD5980
Chemical/Pharm GKB GenePA34337
Clinical trialREV3L
Cancer Resource (Charite)ENSG00000009413
Other databases
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
CoreMineREV3L
GoPubMedREV3L
iHOPREV3L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 17:07:27 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.