Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5980
MIM: 602776
HGNC: 9968
Ensembl: ENSG00000009413
Variants:
dbSNP: 5980
ClinVar: 5980
TCGA: ENSG00000009413
COSMIC: REV3L
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | ||
| PA445058 | Neoplasm Metastasis | Disease | ClinicalAnnotation | associated | PD | ||
| PA445601 | Osteosarcoma | Disease | ClinicalAnnotation | associated | PD | ||
| PA448771 | capecitabine | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449014 | cisplatin | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33474647 | 2021 | Developmental delay with hypotrophy associated with homozygous functionally relevant REV3L variant. | 1 |
| 33607474 | 2021 | Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells. | 4 |
| 33626348 | 2021 | Disruption of DNA polymerase ζ engages an innate immune response. | 6 |
| 34508659 | 2021 | REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps. | 65 |
| 34533226 | 2021 | DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability. | 6 |
| 34597596 | 2021 | The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair. | 11 |
| 34655923 | 2021 | REV3L single nucleotide variants lead to increased susceptibility towards non-small cell lung cancer in the population of Jammu and Kashmir. | 1 |
| 33474647 | 2021 | Developmental delay with hypotrophy associated with homozygous functionally relevant REV3L variant. | 1 |
| 33607474 | 2021 | Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells. | 4 |
| 33626348 | 2021 | Disruption of DNA polymerase ζ engages an innate immune response. | 6 |
| 34508659 | 2021 | REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps. | 65 |
| 34533226 | 2021 | DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability. | 6 |
| 34597596 | 2021 | The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair. | 11 |
| 34655923 | 2021 | REV3L single nucleotide variants lead to increased susceptibility towards non-small cell lung cancer in the population of Jammu and Kashmir. | 1 |
| 31832811 | 2020 | Blood mRNA expression of REV3L and TYMS as potential predictive biomarkers from platinum-based chemotherapy plus pemetrexed in non-small cell lung cancer patients. | 13 |
Citation
Dessen P
REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42086/rev3l
