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REV3L (REV3-like, polymerase (DNA directed), zeta, catalytic subunit)

Identity

Other namesPOLZ
REV3
HGNC (Hugo) REV3L
LocusID (NCBI) 5980
Location 6q21
Location_base_pair Starts at 111620234 and ends at 111804918 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)REV3L   9968
Cards
Entrez_Gene (NCBI)REV3L  5980  REV3-like, polymerase (DNA directed), zeta, catalytic subunit
GeneCards (Weizmann)REV3L
Ensembl (Hinxton)ENSG00000009413 [Gene_View]  chr6:111620234-111804918 [Contig_View]  REV3L [Vega]
ICGC DataPortalENSG00000009413
cBioPortalREV3L
AceView (NCBI)REV3L
Genatlas (Paris)REV3L
WikiGenes5980
SOURCE (Princeton)NM_001286431 NM_001286432 NM_002912
Genomic and cartography
GoldenPath (UCSC)REV3L  -  6q21   chr6:111620234-111804918 -  6q21   [Description]    (hg19-Feb_2009)
EnsemblREV3L - 6q21 [CytoView]
Mapping of homologs : NCBIREV3L [Mapview]
OMIM602776   
Gene and transcription
Genbank (Entrez)AB209256 AF004713 AF035537 AF058701 AF071798
RefSeq transcript (Entrez)NM_001286431 NM_001286432 NM_002912
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NT_025741 NW_001838990 NW_004929328
Consensus coding sequences : CCDS (NCBI)REV3L
Cluster EST : UnigeneHs.232021 [ NCBI ]
CGAP (NCI)Hs.232021
Alternative Splicing : Fast-db (Paris)GSHG0026841
Alternative Splicing GalleryENSG00000009413
Gene ExpressionREV3L [ NCBI-GEO ]     REV3L [ SEEK ]   REV3L [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60673 (Uniprot)
NextProtO60673  [Medical]
With graphics : InterProO60673
Splice isoforms : SwissVarO60673 (Swissvar)
Catalytic activity : Enzyme2.7.7.7 [ Enzyme-Expasy ]   2.7.7.72.7.7.7 [ IntEnz-EBI ]   2.7.7.7 [ BRENDA ]   2.7.7.7 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)DNA_POLYMERASE_B (PS00116)   
Domains : Interpro (EBI)DNA-dir_DNA_pol_B [organisation]   DNA-dir_DNA_pol_B_CS [organisation]   DNA-dir_DNA_pol_B_exonuc [organisation]   DNA-dir_DNA_pol_B_multi_dom [organisation]   DNA_pol_palm_dom [organisation]   RNaseH-like_dom [organisation]   Znf-C4pol [organisation]  
Related proteins : CluSTrO60673
Domain families : Pfam (Sanger)DNA_pol_B (PF00136)    DNA_pol_B_exo1 (PF03104)    zf-C4pol (PF14260)   
Domain families : Pfam (NCBI)pfam00136    pfam03104    pfam14260   
Domain families : Smart (EMBL)POLBc (SM00486)  
DMDM Disease mutations5980
Blocks (Seattle)O60673
PDB (SRS)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
PDB (PDBSum)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
PDB (IMB)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
PDB (RSDB)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
Human Protein AtlasENSG00000009413 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO60673
HPRD04145
IPIIPI00248651   IPI00745230   IPI01015656   IPI00827615   IPI00879141   IPI00855811   
Protein Interaction databases
DIP (DOE-UCLA)O60673
IntAct (EBI)O60673
FunCoupENSG00000009413
BioGRIDREV3L
InParanoidO60673
Interologous Interaction database O60673
IntegromeDBREV3L
STRING (EMBL)REV3L
Ontologies - Pathways
Ontology : AmiGOnucleotide binding  DNA binding  DNA-directed DNA polymerase activity  protein binding  nucleus  chromosome  DNA-dependent DNA replication  nucleotide-excision repair, DNA gap filling  3'-5' exonuclease activity  zeta DNA polymerase complex  translesion synthesis  metal ion binding  4 iron, 4 sulfur cluster binding  
Ontology : EGO-EBInucleotide binding  DNA binding  DNA-directed DNA polymerase activity  protein binding  nucleus  chromosome  DNA-dependent DNA replication  nucleotide-excision repair, DNA gap filling  3'-5' exonuclease activity  zeta DNA polymerase complex  translesion synthesis  metal ion binding  4 iron, 4 sulfur cluster binding  
Pathways : KEGGFanconi anemia pathway   
Protein Interaction DatabaseREV3L
Wikipedia pathwaysREV3L
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)REV3L
snp3D : Map Gene to Disease5980
SNP (GeneSNP Utah)REV3L
SNP : HGBaseREV3L
Genetic variants : HAPMAPREV3L
Exome VariantREV3L
1000_GenomesREV3L 
ICGC programENSG00000009413 
Somatic Mutations in Cancer : COSMICREV3L 
CONAN: Copy Number AnalysisREV3L 
Mutations and Diseases : HGMDREV3L
Mutations and Diseases : intOGenREV3L
Genomic VariantsREV3L  REV3L [DGVbeta]
dbVarREV3L
ClinVarREV3L
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM602776   
MedgenREV3L
GENETestsREV3L
Disease Genetic AssociationREV3L
Huge Navigator REV3L [HugePedia]  REV3L [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneREV3L
Homology/Alignments : Family Browser (UCSC)REV3L
Phylogenetic Trees/Animal Genes : TreeFamREV3L
Chemical/Protein Interactions : CTD5980
Chemical/Pharm GKB GenePA34337
Clinical trialREV3L
Cancer Resource (Charite)ENSG00000009413
Other databases
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
CoreMineREV3L
iHOPREV3L
OncoSearchREV3L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:02:46 CEST 2014

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