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REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit)

Identity

Other namesPOLZ
REV3
HGNC (Hugo) REV3L
LocusID (NCBI) 5980
Atlas_Id 42086
Location 6q21
Location_base_pair Starts at 111620234 and ends at 111804918 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
REV3L 6q21 / ARHGEF25 12q13.3REV3L 6q21 / FN3KRP 17q25.3REV3L 6q21 / FYN 6q21
REV3L 6q21 / LAMA4 6q21REV3L 6q21 / SOBP 6q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)REV3L   9968
Cards
Entrez_Gene (NCBI)REV3L  5980  REV3 like, DNA directed polymerase zeta catalytic subunit
GeneCards (Weizmann)REV3L
Ensembl hg19 (Hinxton)ENSG00000009413 [Gene_View]  chr6:111620234-111804918 [Contig_View]  REV3L [Vega]
Ensembl hg38 (Hinxton)ENSG00000009413 [Gene_View]  chr6:111620234-111804918 [Contig_View]  REV3L [Vega]
ICGC DataPortalENSG00000009413
TCGA cBioPortalREV3L
AceView (NCBI)REV3L
Genatlas (Paris)REV3L
WikiGenes5980
SOURCE (Princeton)REV3L
Genomic and cartography
GoldenPath hg19 (UCSC)REV3L  -     chr6:111620234-111804918 -  6q21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)REV3L  -     6q21   [Description]    (hg38-Dec_2013)
EnsemblREV3L - 6q21 [CytoView hg19]  REV3L - 6q21 [CytoView hg38]
Mapping of homologs : NCBIREV3L [Mapview hg19]  REV3L [Mapview hg38]
OMIM602776   
Gene and transcription
Genbank (Entrez)AB209256 AF004713 AF035537 AF058701 AF071798
RefSeq transcript (Entrez)NM_001286431 NM_001286432 NM_002912
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_025741 NW_004929328
Consensus coding sequences : CCDS (NCBI)REV3L
Cluster EST : UnigeneHs.232021 [ NCBI ]
CGAP (NCI)Hs.232021
Alternative Splicing : Fast-db (Paris)GSHG0026841
Alternative Splicing GalleryENSG00000009413
Gene ExpressionREV3L [ NCBI-GEO ]     REV3L [ SEEK ]   REV3L [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)5980
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60673 (Uniprot)
NextProtO60673  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60673
Splice isoforms : SwissVarO60673 (Swissvar)
Catalytic activity : Enzyme2.7.7.7 [ Enzyme-Expasy ]   2.7.7.7 [ Enzyme-SRS ]   2.7.7.7 [ IntEnz-EBI ]   2.7.7.7 [ PRIAM ]   2.7.7.7 [ BRENDA ]   2.7.7.7 [ KEGG ]   2.7.7.7 [ IUBMB ]
PhosPhoSitePlusO60673
Domaine pattern : Prosite (Expaxy)DNA_POLYMERASE_B (PS00116)   
Domains : Interpro (EBI)DNA-dir_DNA_pol_B    DNA-dir_DNA_pol_B_CS    DNA-dir_DNA_pol_B_exonuc    DNA-dir_DNA_pol_B_multi_dom    DNA_pol_palm_dom    PolZ_Rev3    RNaseH-like_dom    Znf-C4pol   
Domain families : Pfam (Sanger)DNA_pol_B (PF00136)    DNA_pol_B_exo1 (PF03104)    zf-C4pol (PF14260)   
Domain families : Pfam (NCBI)pfam00136    pfam03104    pfam14260   
Domain families : Smart (EMBL)POLBc (SM00486)  
DMDM Disease mutations5980
Blocks (Seattle)REV3L
PDB (SRS)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
PDB (PDBSum)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
PDB (IMB)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
PDB (RSDB)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
Structural Biology KnowledgeBase3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
SCOP (Structural Classification of Proteins)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
CATH (Classification of proteins structures)3ABD    3ABE    3VU7    4EXT    4GK0    4GK5   
Human Protein AtlasENSG00000009413
Peptide AtlasO60673
HPRD04145
IPIIPI00248651   IPI00745230   IPI01015656   IPI00827615   IPI00879141   IPI00855811   
Protein Interaction databases
DIP (DOE-UCLA)O60673
IntAct (EBI)O60673
FunCoupENSG00000009413
BioGRIDREV3L
IntegromeDBREV3L
STRING (EMBL)REV3L
ZODIACREV3L
Ontologies - Pathways
QuickGOO60673
Ontology : AmiGOnucleotide binding  DNA binding  DNA-directed DNA polymerase activity  protein binding  nucleoplasm  nucleolus  DNA-dependent DNA replication  DNA repair  3'-5' exonuclease activity  zeta DNA polymerase complex  translesion synthesis  error-prone translesion synthesis  error-prone translesion synthesis  metal ion binding  4 iron, 4 sulfur cluster binding  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBInucleotide binding  DNA binding  DNA-directed DNA polymerase activity  protein binding  nucleoplasm  nucleolus  DNA-dependent DNA replication  DNA repair  3'-5' exonuclease activity  zeta DNA polymerase complex  translesion synthesis  error-prone translesion synthesis  error-prone translesion synthesis  metal ion binding  4 iron, 4 sulfur cluster binding  nucleic acid phosphodiester bond hydrolysis  
Pathways : KEGGFanconi anemia pathway   
Protein Interaction DatabaseREV3L
Atlas of Cancer Signalling NetworkREV3L
Wikipedia pathwaysREV3L
Orthology - Evolution
OrthoDB5980
GeneTree (enSembl)ENSG00000009413
Phylogenetic Trees/Animal Genes : TreeFamREV3L
Homologs : HomoloGeneREV3L
Homology/Alignments : Family Browser (UCSC)REV3L
Gene fusions - Rearrangements
Fusion: TCGAREV3L 6q21 ARHGEF25 12q13.3 BRCA
Fusion: TCGAREV3L 6q21 FN3KRP 17q25.3 LGG
Fusion: TCGAREV3L 6q21 FYN 6q21 BRCA SKCM
Fusion: TCGAREV3L 6q21 LAMA4 6q21 PRAD
Fusion: TCGAREV3L 6q21 SOBP 6q21 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerREV3L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)REV3L
dbVarREV3L
ClinVarREV3L
1000_GenomesREV3L 
Exome Variant ServerREV3L
Exome Aggregation Consortium (ExAC)ENSG00000009413
SNP (GeneSNP Utah)REV3L
SNP : HGBaseREV3L
Genetic variants : HAPMAPREV3L
Genomic Variants (DGV)REV3L [DGVbeta]
Mutations
ICGC Data PortalREV3L 
TCGA Data PortalREV3L 
Tumor PortalREV3L
TCGA Copy Number PortalREV3L
Somatic Mutations in Cancer : COSMICREV3L 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch REV3L
DgiDB (Drug Gene Interaction Database)REV3L
DoCM (Curated mutations)REV3L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)REV3L (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:111620234-111804918
CONAN: Copy Number AnalysisREV3L 
Mutations and Diseases : HGMDREV3L
OMIM602776   
MedgenREV3L
NextProtO60673 [Medical]
TSGene5980
GENETestsREV3L
Huge Navigator REV3L [HugePedia]  REV3L [HugeCancerGEM]
snp3D : Map Gene to Disease5980
BioCentury BCIQREV3L
General knowledge
Chemical/Protein Interactions : CTD5980
Chemical/Pharm GKB GenePA34337
Clinical trialREV3L
Other databases
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineREV3L
GoPubMedREV3L
iHOPREV3L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 19:23:36 CET 2016

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