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RFC1 (replication factor C subunit 1)

Identity

Other namesA1
MHCBFB
PO-GA
RECC1
RFC
RFC140
HGNC (Hugo) RFC1
LocusID (NCBI) 5981
Atlas_Id 42087
Location 4p14
Location_base_pair Starts at 39289069 and ends at 39368001 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EPS15L1 (19p13.11) / RFC1 (4p14)RFC1 (4p14) / TEK (9p21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RFC1   9969
Cards
Entrez_Gene (NCBI)RFC1  5981  replication factor C subunit 1
GeneCards (Weizmann)RFC1
Ensembl hg19 (Hinxton)ENSG00000035928 [Gene_View]  chr4:39289069-39368001 [Contig_View]  RFC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000035928 [Gene_View]  chr4:39289069-39368001 [Contig_View]  RFC1 [Vega]
ICGC DataPortalENSG00000035928
TCGA cBioPortalRFC1
AceView (NCBI)RFC1
Genatlas (Paris)RFC1
WikiGenes5981
SOURCE (Princeton)RFC1
Genomic and cartography
GoldenPath hg19 (UCSC)RFC1  -     chr4:39289069-39368001 -  4p14   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RFC1  -     4p14   [Description]    (hg38-Dec_2013)
EnsemblRFC1 - 4p14 [CytoView hg19]  RFC1 - 4p14 [CytoView hg38]
Mapping of homologs : NCBIRFC1 [Mapview hg19]  RFC1 [Mapview hg38]
OMIM102579   
Gene and transcription
Genbank (Entrez)AF040250 AJ564999 AK291612 BC010387 BC035297
RefSeq transcript (Entrez)NM_001204747 NM_002913
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_006238 NW_004929317
Consensus coding sequences : CCDS (NCBI)RFC1
Cluster EST : UnigeneHs.507475 [ NCBI ]
CGAP (NCI)Hs.507475
Alternative Splicing : Fast-db (Paris)GSHG0023204
Alternative Splicing GalleryENSG00000035928
Gene ExpressionRFC1 [ NCBI-GEO ]   RFC1 [ EBI - ARRAY_EXPRESS ]   RFC1 [ SEEK ]   RFC1 [ MEM ]
Gene Expression Viewer (FireBrowse)RFC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)5981
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35251 (Uniprot)
NextProtP35251  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35251
Splice isoforms : SwissVarP35251 (Swissvar)
PhosPhoSitePlusP35251
Domaine pattern : Prosite (Expaxy)BRCT (PS50172)   
Domains : Interpro (EBI)AAA+_ATPase    ATPase_AAA_core    BRCT_dom    DNA_pol3_clamp-load_cplx_C    DNA_replication_fac_RFC1_C    P-loop_NTPase    RFC1   
Domain families : Pfam (Sanger)AAA (PF00004)    BRCT (PF00533)    RFC1 (PF08519)   
Domain families : Pfam (NCBI)pfam00004    pfam00533    pfam08519   
Domain families : Smart (EMBL)AAA (SM00382)  BRCT (SM00292)  
DMDM Disease mutations5981
Blocks (Seattle)RFC1
PDB (SRS)2EBU    2K6G    2K7F   
PDB (PDBSum)2EBU    2K6G    2K7F   
PDB (IMB)2EBU    2K6G    2K7F   
PDB (RSDB)2EBU    2K6G    2K7F   
Structural Biology KnowledgeBase2EBU    2K6G    2K7F   
SCOP (Structural Classification of Proteins)2EBU    2K6G    2K7F   
CATH (Classification of proteins structures)2EBU    2K6G    2K7F   
SuperfamilyP35251
Human Protein AtlasENSG00000035928
Peptide AtlasP35251
HPRD00024
IPIIPI00375358   IPI00375359   IPI00382816   IPI00965714   IPI00964047   IPI00966063   IPI00965979   
Protein Interaction databases
DIP (DOE-UCLA)P35251
IntAct (EBI)P35251
FunCoupENSG00000035928
BioGRIDRFC1
STRING (EMBL)RFC1
ZODIACRFC1
Ontologies - Pathways
QuickGOP35251
Ontology : AmiGOtelomere maintenance via recombination  DNA binding  DNA clamp loader activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA replication factor C complex  DNA-dependent DNA replication  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  transcription, DNA-templated  regulation of transcription, DNA-templated  telomere maintenance via telomerase  enzyme activator activity  translesion synthesis  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  positive regulation of catalytic activity  extracellular exosome  error-free translesion synthesis  
Ontology : EGO-EBItelomere maintenance via recombination  DNA binding  DNA clamp loader activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA replication factor C complex  DNA-dependent DNA replication  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  transcription, DNA-templated  regulation of transcription, DNA-templated  telomere maintenance via telomerase  enzyme activator activity  translesion synthesis  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  positive regulation of catalytic activity  extracellular exosome  error-free translesion synthesis  
Pathways : BIOCARTAALK in cardiac myocytes [Genes]   
Pathways : KEGGDNA replication    Nucleotide excision repair    Mismatch repair   
NDEx Network
Atlas of Cancer Signalling NetworkRFC1
Wikipedia pathwaysRFC1
Orthology - Evolution
OrthoDB5981
GeneTree (enSembl)ENSG00000035928
Phylogenetic Trees/Animal Genes : TreeFamRFC1
Homologs : HomoloGeneRFC1
Homology/Alignments : Family Browser (UCSC)RFC1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerRFC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RFC1
dbVarRFC1
ClinVarRFC1
1000_GenomesRFC1 
Exome Variant ServerRFC1
ExAC (Exome Aggregation Consortium)RFC1 (select the gene name)
SNP (GeneSNP Utah)RFC1
SNP : HGBaseRFC1
Genetic variants : HAPMAPRFC1
Genomic Variants (DGV)RFC1 [DGVbeta]
Mutations
ICGC Data PortalRFC1 
TCGA Data PortalRFC1 
Broad Tumor PortalRFC1
OASIS PortalRFC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRFC1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RFC1
DgiDB (Drug Gene Interaction Database)RFC1
DoCM (Curated mutations)RFC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RFC1 (select a term)
intoGenRFC1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:39289069-39368001
CONAN: Copy Number AnalysisRFC1 
Mutations and Diseases : HGMDRFC1
OMIM102579   
MedgenRFC1
Genetic Testing Registry RFC1
NextProtP35251 [Medical]
TSGene5981
GENETestsRFC1
Huge Navigator RFC1 [HugePedia]  RFC1 [HugeCancerGEM]
snp3D : Map Gene to Disease5981
BioCentury BCIQRFC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5981
Chemical/Pharm GKB GenePA34338
Clinical trialRFC1
Miscellaneous
canSAR (ICR)RFC1 (select the gene name)
Probes
Litterature
PubMed181 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRFC1
GoPubMedRFC1
iHOPRFC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 18:02:01 CEST 2016

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