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RFC2 (replication factor C subunit 2)

Identity

Alias_namesreplication factor C (activator 1) 2 (40kD)
replication factor C (activator 1) 2, 40kDa
Alias_symbol (synonym)A1
RFC40
Other alias
HGNC (Hugo) RFC2
LocusID (NCBI) 5982
Atlas_Id 42088
Location 7q11.23  [Link to chromosome band 7q11]
Location_base_pair Starts at 74231502 and ends at 74254458 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLIP2 (7q11.23) / RFC2 (7q11.23)LINC00466 (1p31.3) / RFC2 (7q11.23)RFC2 (7q11.23) / HSP90AA1 (14q32.31)
RFC2 (7q11.23) / IL6ST (5q11.2)RFC2 (7q11.23) / RFC2 (7q11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RFC2   9970
Cards
Entrez_Gene (NCBI)RFC2  5982  replication factor C subunit 2
AliasesRFC40
GeneCards (Weizmann)RFC2
Ensembl hg19 (Hinxton)ENSG00000049541 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000049541 [Gene_View]  chr7:74231502-74254458 [Contig_View]  RFC2 [Vega]
ICGC DataPortalENSG00000049541
TCGA cBioPortalRFC2
AceView (NCBI)RFC2
Genatlas (Paris)RFC2
WikiGenes5982
SOURCE (Princeton)RFC2
Genetics Home Reference (NIH)RFC2
Genomic and cartography
GoldenPath hg38 (UCSC)RFC2  -     chr7:74231502-74254458 -  7q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RFC2  -     7q11.23   [Description]    (hg19-Feb_2009)
EnsemblRFC2 - 7q11.23 [CytoView hg19]  RFC2 - 7q11.23 [CytoView hg38]
Mapping of homologs : NCBIRFC2 [Mapview hg19]  RFC2 [Mapview hg38]
OMIM600404   
Gene and transcription
Genbank (Entrez)AB451243 AB451368 AL560344 AW450467 BC002813
RefSeq transcript (Entrez)NM_001278791 NM_001278792 NM_001278793 NM_002914 NM_181471
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RFC2
Cluster EST : UnigeneHs.647062 [ NCBI ]
CGAP (NCI)Hs.647062
Alternative Splicing GalleryENSG00000049541
Gene ExpressionRFC2 [ NCBI-GEO ]   RFC2 [ EBI - ARRAY_EXPRESS ]   RFC2 [ SEEK ]   RFC2 [ MEM ]
Gene Expression Viewer (FireBrowse)RFC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5982
GTEX Portal (Tissue expression)RFC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35250   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35250  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35250
Splice isoforms : SwissVarP35250
PhosPhoSitePlusP35250
Domains : Interpro (EBI)AAA+_ATPase    ATPase_AAA_core    DNA_pol3_clamp-load_cplx_C    P-loop_NTPase    Rep_factorC_C   
Domain families : Pfam (Sanger)AAA (PF00004)    Rep_fac_C (PF08542)   
Domain families : Pfam (NCBI)pfam00004    pfam08542   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)RFC2
DMDM Disease mutations5982
Blocks (Seattle)RFC2
SuperfamilyP35250
Human Protein AtlasENSG00000049541
Peptide AtlasP35250
HPRD02675
IPIIPI00017412   IPI00218280   IPI00946835   IPI00947011   IPI00947452   IPI00945248   IPI00944904   IPI00947438   IPI00946644   IPI00947280   IPI00945072   IPI00979054   
Protein Interaction databases
DIP (DOE-UCLA)P35250
IntAct (EBI)P35250
FunCoupENSG00000049541
BioGRIDRFC2
STRING (EMBL)RFC2
ZODIACRFC2
Ontologies - Pathways
QuickGOP35250
Ontology : AmiGOtelomere maintenance via recombination  DNA clamp loader activity  protein binding  ATP binding  nucleoplasm  DNA replication factor C complex  DNA replication  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  enzyme binding  translesion synthesis  Ctf18 RFC-like complex  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  single-stranded DNA-dependent ATPase activity  error-free translesion synthesis  positive regulation of DNA-directed DNA polymerase activity  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBItelomere maintenance via recombination  DNA clamp loader activity  protein binding  ATP binding  nucleoplasm  DNA replication factor C complex  DNA replication  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  enzyme binding  translesion synthesis  Ctf18 RFC-like complex  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  single-stranded DNA-dependent ATPase activity  error-free translesion synthesis  positive regulation of DNA-directed DNA polymerase activity  regulation of signal transduction by p53 class mediator  
Pathways : KEGGDNA replication    Nucleotide excision repair    Mismatch repair   
NDEx NetworkRFC2
Atlas of Cancer Signalling NetworkRFC2
Wikipedia pathwaysRFC2
Orthology - Evolution
OrthoDB5982
GeneTree (enSembl)ENSG00000049541
Phylogenetic Trees/Animal Genes : TreeFamRFC2
HOVERGENP35250
HOGENOMP35250
Homologs : HomoloGeneRFC2
Homology/Alignments : Family Browser (UCSC)RFC2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRFC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RFC2
dbVarRFC2
ClinVarRFC2
1000_GenomesRFC2 
Exome Variant ServerRFC2
ExAC (Exome Aggregation Consortium)RFC2 (select the gene name)
Genetic variants : HAPMAP5982
Genomic Variants (DGV)RFC2 [DGVbeta]
DECIPHERRFC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRFC2 
Mutations
ICGC Data PortalRFC2 
TCGA Data PortalRFC2 
Broad Tumor PortalRFC2
OASIS PortalRFC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRFC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRFC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RFC2
DgiDB (Drug Gene Interaction Database)RFC2
DoCM (Curated mutations)RFC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RFC2 (select a term)
intoGenRFC2
Cancer3DRFC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600404   
Orphanet145   
MedgenRFC2
Genetic Testing Registry RFC2
NextProtP35250 [Medical]
TSGene5982
GENETestsRFC2
Target ValidationRFC2
Huge Navigator RFC2 [HugePedia]
snp3D : Map Gene to Disease5982
BioCentury BCIQRFC2
ClinGenRFC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5982
Chemical/Pharm GKB GenePA34339
Clinical trialRFC2
Miscellaneous
canSAR (ICR)RFC2 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRFC2
EVEXRFC2
GoPubMedRFC2
iHOPRFC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:53:02 CEST 2017

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