RFC2 (replication factor C subunit 2)

2003-02-01  

Identity

HGNC
LOCATION
7q11.23
LOCUSID
ALIAS
RFC40
FUSION GENES

Other Information

Locus ID:

NCBI: 5982
MIM: 600404
HGNC: 9970
Ensembl: ENSG00000049541

Variants:

dbSNP: 5982
ClinVar: 5982
TCGA: ENSG00000049541
COSMIC: RFC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000049541ENST00000055077P35250
ENSG00000049541ENST00000352131P35250
ENSG00000049541ENST00000352131Q75MT5
ENSG00000049541ENST00000463194H7C5G4
ENSG00000049541ENST00000470266H7C5Q7
ENSG00000049541ENST00000479105H7C5P1
ENSG00000049541ENST00000480432F8WC37
ENSG00000049541ENST00000485545H7C596
ENSG00000049541ENST00000491206H7C5S7
ENSG00000049541ENST00000493156F8WDC9
ENSG00000049541ENST00000494019H7C5A0
ENSG00000049541ENST00000497430H7C5P4
ENSG00000049541ENST00000621097A0A087WVY3

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
DNA replicationKEGGko03030
Nucleotide excision repairKEGGko03420
Mismatch repairKEGGko03430
DNA replicationKEGGhsa03030
Nucleotide excision repairKEGGhsa03420
Mismatch repairKEGGhsa03430
RF-C complexKEGGhsa_M00289
BRCA1-associated genome surveillance complex (BASC)KEGGhsa_M00295
RF-C complexKEGGM00289
BRCA1-associated genome surveillance complex (BASC)KEGGM00295
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Leading Strand SynthesisREACTOMER-HSA-69109
Polymerase switchingREACTOMER-HSA-69091
Lagging Strand SynthesisREACTOMER-HSA-69186
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Extension of TelomeresREACTOMER-HSA-180786
Telomere C-strand (Lagging Strand) SynthesisREACTOMER-HSA-174417
Polymerase switching on the C-strand of the telomereREACTOMER-HSA-174411
DNA ReplicationREACTOMER-HSA-69306
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Resolution of AP sites via the multiple-nucleotide patch replacement pathwayREACTOMER-HSA-110373
PCNA-Dependent Long Patch Base Excision RepairREACTOMER-HSA-5651801
DNA Damage BypassREACTOMER-HSA-73893
Recognition of DNA damage by PCNA-containing replication complexREACTOMER-HSA-110314
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Translesion synthesis by REV1REACTOMER-HSA-110312
Translesion Synthesis by POLHREACTOMER-HSA-110320
Translesion synthesis by POLKREACTOMER-HSA-5655862
Translesion synthesis by POLIREACTOMER-HSA-5656121
Termination of translesion DNA synthesisREACTOMER-HSA-5656169
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Dual Incision in GG-NERREACTOMER-HSA-5696400
Gap-filling DNA repair synthesis and ligation in GG-NERREACTOMER-HSA-5696397
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
120368852002Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis.30
182457742008DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex.14
192376062009Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.11
205225372010Variation within DNA repair pathway genes and risk of multiple sclerosis.11
202268692010Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations.8
156553532005The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival.6
205744542010Polymorphisms in the base excision repair pathway and graft-versus-host disease.6
164130172006Cyclic AMP regulates the expression and nuclear translocation of RFC40 in MCF7 cells.2

Citation

Dessen P

RFC2 (replication factor C subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42088/rfc2