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RFC3 (replication factor C subunit 3)

Identity

Alias (NCBI)RFC38
HGNC (Hugo) RFC3
HGNC Alias symbRFC38
MGC5276
HGNC Alias nameRFC, 38 kD subunit
 A1 38 kDa subunit
HGNC Previous namereplication factor C (activator 1) 3 (38kD)
 replication factor C (activator 1) 3, 38kDa
LocusID (NCBI) 5983
Atlas_Id 42089
Location 13q13.2  [Link to chromosome band 13q13]
Location_base_pair Starts at 33818069 and ends at 33966558 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FOXP2 (7q31.1) / RFC3 (13q13.2)PAN3 (13q12.2) / RFC3 (13q13.2)RASSF4 (10q11.21) / RFC3 (13q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(13)(q12q13) PAN3/RFC3


External links

Nomenclature
HGNC (Hugo)RFC3   9971
Cards
Entrez_Gene (NCBI)RFC3    replication factor C subunit 3
AliasesRFC38
GeneCards (Weizmann)RFC3
Ensembl hg19 (Hinxton)ENSG00000133119 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133119 [Gene_View]  ENSG00000133119 [Sequence]  chr13:33818069-33966558 [Contig_View]  RFC3 [Vega]
ICGC DataPortalENSG00000133119
TCGA cBioPortalRFC3
AceView (NCBI)RFC3
Genatlas (Paris)RFC3
SOURCE (Princeton)RFC3
Genetics Home Reference (NIH)RFC3
Genomic and cartography
GoldenPath hg38 (UCSC)RFC3  -     chr13:33818069-33966558 +  13q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RFC3  -     13q13.2   [Description]    (hg19-Feb_2009)
GoldenPathRFC3 - 13q13.2 [CytoView hg19]  RFC3 - 13q13.2 [CytoView hg38]
ImmunoBaseENSG00000133119
genome Data Viewer NCBIRFC3 [Mapview hg19]  
OMIM600405   
Gene and transcription
Genbank (Entrez)AA447424 AI221523 AK128459 AK222572 AK296527
RefSeq transcript (Entrez)NM_002915 NM_181558
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RFC3
Alternative Splicing GalleryENSG00000133119
Gene ExpressionRFC3 [ NCBI-GEO ]   RFC3 [ EBI - ARRAY_EXPRESS ]   RFC3 [ SEEK ]   RFC3 [ MEM ]
Gene Expression Viewer (FireBrowse)RFC3 [ Firebrowse - Broad ]
GenevisibleExpression of RFC3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5983
GTEX Portal (Tissue expression)RFC3
Human Protein AtlasENSG00000133119-RFC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40938   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40938  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40938
Splice isoforms : SwissVarP40938
PhosPhoSitePlusP40938
Domains : Interpro (EBI)AAA+_ATPase    DNA_pol3_clamp-load_cplx_C    P-loop_NTPase   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)RFC3
Blocks (Seattle)RFC3
SuperfamilyP40938
Human Protein Atlas [tissue]ENSG00000133119-RFC3 [tissue]
Peptide AtlasP40938
HPRD02676
IPIIPI00031521   IPI00373882   
Protein Interaction databases
DIP (DOE-UCLA)P40938
IntAct (EBI)P40938
BioGRIDRFC3
STRING (EMBL)RFC3
ZODIACRFC3
Ontologies - Pathways
QuickGOP40938
Ontology : AmiGODNA synthesis involved in DNA repair  DNA binding  DNA clamp loader activity  DNA clamp loader activity  DNA clamp loader activity  protein binding  nucleus  nucleoplasm  DNA replication factor C complex  DNA replication factor C complex  DNA replication factor C complex  DNA replication  DNA replication  DNA-dependent DNA replication  DNA strand elongation involved in DNA replication  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  ATPase activity  single-stranded DNA-dependent ATP-dependent DNA helicase activity  translesion synthesis  Ctf18 RFC-like complex  telomere maintenance via semi-conservative replication  DNA duplex unwinding  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  response to organophosphorus  error-free translesion synthesis  positive regulation of DNA-directed DNA polymerase activity  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIDNA synthesis involved in DNA repair  DNA binding  DNA clamp loader activity  DNA clamp loader activity  DNA clamp loader activity  protein binding  nucleus  nucleoplasm  DNA replication factor C complex  DNA replication factor C complex  DNA replication factor C complex  DNA replication  DNA replication  DNA-dependent DNA replication  DNA strand elongation involved in DNA replication  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  ATPase activity  single-stranded DNA-dependent ATP-dependent DNA helicase activity  translesion synthesis  Ctf18 RFC-like complex  telomere maintenance via semi-conservative replication  DNA duplex unwinding  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  response to organophosphorus  error-free translesion synthesis  positive regulation of DNA-directed DNA polymerase activity  regulation of signal transduction by p53 class mediator  
Pathways : KEGGDNA replication    Nucleotide excision repair    Mismatch repair   
NDEx NetworkRFC3
Atlas of Cancer Signalling NetworkRFC3
Wikipedia pathwaysRFC3
Orthology - Evolution
OrthoDB5983
GeneTree (enSembl)ENSG00000133119
Phylogenetic Trees/Animal Genes : TreeFamRFC3
HOGENOMP40938
Homologs : HomoloGeneRFC3
Homology/Alignments : Family Browser (UCSC)RFC3
Gene fusions - Rearrangements
Fusion : MitelmanPAN3/RFC3 [13q12.2/13q13.2]  
Fusion : QuiverRFC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRFC3 [hg38]
dbVarRFC3
ClinVarRFC3
MonarchRFC3
1000_GenomesRFC3 
Exome Variant ServerRFC3
GNOMAD BrowserENSG00000133119
Varsome BrowserRFC3
Genomic Variants (DGV)RFC3 [DGVbeta]
DECIPHERRFC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRFC3 
Mutations
ICGC Data PortalRFC3 
TCGA Data PortalRFC3 
Broad Tumor PortalRFC3
OASIS PortalRFC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRFC3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRFC3
Mutations and Diseases : HGMDRFC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RFC3
DgiDB (Drug Gene Interaction Database)RFC3
DoCM (Curated mutations)RFC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RFC3 (select a term)
intoGenRFC3
Cancer3DRFC3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600405   
Orphanet
DisGeNETRFC3
MedgenRFC3
Genetic Testing Registry RFC3
NextProtP40938 [Medical]
GENETestsRFC3
Target ValidationRFC3
Huge Navigator RFC3 [HugePedia]
ClinGenRFC3
Clinical trials, drugs, therapy
MyCancerGenomeRFC3
Protein Interactions : CTD
Pharm GKB GenePA34340
PharosP40938
Clinical trialRFC3
Miscellaneous
canSAR (ICR)RFC3 (select the gene name)
HarmonizomeRFC3
DataMed IndexRFC3
Probes
Litterature
PubMed123 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRFC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:34:51 CET 2021

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