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RFC4 (replication factor C subunit 4)

Identity

Alias_namesreplication factor C (activator 1) 4 (37kD)
replication factor C (activator 1) 4, 37kDa
Alias_symbol (synonym)A1
RFC37
Other alias
HGNC (Hugo) RFC4
LocusID (NCBI) 5984
Atlas_Id 42090
Location 3q27.3  [Link to chromosome band 3q27]
Location_base_pair Starts at 186507682 and ends at 186524290 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RFC4 (3q27.3) / RFC4 (3q27.3)SENP7 (3q12.3) / RFC4 (3q27.3)USP34 (2p15) / RFC4 (3q27.3)
SENP7 3q12.3 / RFC4 3q27.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RFC4   9972
Cards
Entrez_Gene (NCBI)RFC4  5984  replication factor C subunit 4
AliasesA1; RFC37
GeneCards (Weizmann)RFC4
Ensembl hg19 (Hinxton)ENSG00000163918 [Gene_View]  chr3:186507682-186524290 [Contig_View]  RFC4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163918 [Gene_View]  chr3:186507682-186524290 [Contig_View]  RFC4 [Vega]
ICGC DataPortalENSG00000163918
TCGA cBioPortalRFC4
AceView (NCBI)RFC4
Genatlas (Paris)RFC4
WikiGenes5984
SOURCE (Princeton)RFC4
Genetics Home Reference (NIH)RFC4
Genomic and cartography
GoldenPath hg19 (UCSC)RFC4  -     chr3:186507682-186524290 -  3q27.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RFC4  -     3q27.3   [Description]    (hg38-Dec_2013)
EnsemblRFC4 - 3q27.3 [CytoView hg19]  RFC4 - 3q27.3 [CytoView hg38]
Mapping of homologs : NCBIRFC4 [Mapview hg19]  RFC4 [Mapview hg38]
OMIM102577   
Gene and transcription
Genbank (Entrez)AA521171 AK297282 BC017452 BC024022 BM837975
RefSeq transcript (Entrez)NM_002916 NM_181573
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)RFC4
Cluster EST : UnigeneHs.732098 [ NCBI ]
CGAP (NCI)Hs.732098
Alternative Splicing GalleryENSG00000163918
Gene ExpressionRFC4 [ NCBI-GEO ]   RFC4 [ EBI - ARRAY_EXPRESS ]   RFC4 [ SEEK ]   RFC4 [ MEM ]
Gene Expression Viewer (FireBrowse)RFC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5984
GTEX Portal (Tissue expression)RFC4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35249   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35249  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35249
Splice isoforms : SwissVarP35249
PhosPhoSitePlusP35249
Domains : Interpro (EBI)AAA+_ATPase    ATPase_AAA_core    DNA_pol3_clamp-load_cplx_C    P-loop_NTPase    Rep_factorC_C   
Domain families : Pfam (Sanger)AAA (PF00004)    Rep_fac_C (PF08542)   
Domain families : Pfam (NCBI)pfam00004    pfam08542   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)RFC4
DMDM Disease mutations5984
Blocks (Seattle)RFC4
SuperfamilyP35249
Human Protein AtlasENSG00000163918
Peptide AtlasP35249
HPRD00022
IPIIPI00017381   IPI00792595   IPI00925945   IPI00925652   IPI00925397   IPI00925227   IPI00795756   IPI00924737   IPI00927827   
Protein Interaction databases
DIP (DOE-UCLA)P35249
IntAct (EBI)P35249
FunCoupENSG00000163918
BioGRIDRFC4
STRING (EMBL)RFC4
ZODIACRFC4
Ontologies - Pathways
QuickGOP35249
Ontology : AmiGOtelomere maintenance via recombination  DNA clamp loader activity  DNA clamp loader activity  protein binding  ATP binding  nucleoplasm  DNA replication factor C complex  DNA replication  DNA strand elongation involved in DNA replication  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  enzyme binding  translesion synthesis  Ctf18 RFC-like complex  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  single-stranded DNA-dependent ATPase activity  error-free translesion synthesis  positive regulation of DNA-directed DNA polymerase activity  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBItelomere maintenance via recombination  DNA clamp loader activity  DNA clamp loader activity  protein binding  ATP binding  nucleoplasm  DNA replication factor C complex  DNA replication  DNA strand elongation involved in DNA replication  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  enzyme binding  translesion synthesis  Ctf18 RFC-like complex  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  single-stranded DNA-dependent ATPase activity  error-free translesion synthesis  positive regulation of DNA-directed DNA polymerase activity  regulation of signal transduction by p53 class mediator  
Pathways : KEGGDNA replication    Nucleotide excision repair    Mismatch repair   
NDEx NetworkRFC4
Atlas of Cancer Signalling NetworkRFC4
Wikipedia pathwaysRFC4
Orthology - Evolution
OrthoDB5984
GeneTree (enSembl)ENSG00000163918
Phylogenetic Trees/Animal Genes : TreeFamRFC4
HOVERGENP35249
HOGENOMP35249
Homologs : HomoloGeneRFC4
Homology/Alignments : Family Browser (UCSC)RFC4
Gene fusions - Rearrangements
Fusion : MitelmanSENP7/RFC4 [3q12.3/3q27.3]  [t(3;3)(q12;q27)]  
Fusion: TCGASENP7 3q12.3 RFC4 3q27.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRFC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RFC4
dbVarRFC4
ClinVarRFC4
1000_GenomesRFC4 
Exome Variant ServerRFC4
ExAC (Exome Aggregation Consortium)RFC4 (select the gene name)
Genetic variants : HAPMAP5984
Genomic Variants (DGV)RFC4 [DGVbeta]
DECIPHER (Syndromes)3:186507682-186524290  ENSG00000163918
CONAN: Copy Number AnalysisRFC4 
Mutations
ICGC Data PortalRFC4 
TCGA Data PortalRFC4 
Broad Tumor PortalRFC4
OASIS PortalRFC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRFC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRFC4
intOGen PortalRFC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RFC4
DgiDB (Drug Gene Interaction Database)RFC4
DoCM (Curated mutations)RFC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RFC4 (select a term)
intoGenRFC4
Cancer3DRFC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM102577   
Orphanet
MedgenRFC4
Genetic Testing Registry RFC4
NextProtP35249 [Medical]
TSGene5984
GENETestsRFC4
Huge Navigator RFC4 [HugePedia]
snp3D : Map Gene to Disease5984
BioCentury BCIQRFC4
ClinGenRFC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5984
Chemical/Pharm GKB GenePA34341
Clinical trialRFC4
Miscellaneous
canSAR (ICR)RFC4 (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRFC4
EVEXRFC4
GoPubMedRFC4
iHOPRFC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:24:50 CET 2017

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