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RFC5 (replication factor C subunit 5)

Identity

Alias_namesreplication factor C (activator 1) 5 (36.5kD)
replication factor C (activator 1) 5, 36.5kDa
Alias_symbol (synonym)RFC36
Other alias
HGNC (Hugo) RFC5
LocusID (NCBI) 5985
Atlas_Id 42091
Location 12q24.23  [Link to chromosome band 12q24]
Location_base_pair Starts at 118016661 and ends at 118032237 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CIT (12q24.23) / RFC5 (12q24.23)NFKBIA (14q13.2) / RFC5 (12q24.23)WSB2 (12q24.23) / RFC5 (12q24.23)
WSB2 12q24.23 / RFC5 12q24.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Lung: Translocations in Small Cell Carcinoma
WSB2/RFC5 (12q24)
CIT/RFC5 (12q24)


External links

Nomenclature
HGNC (Hugo)RFC5   9973
Cards
Entrez_Gene (NCBI)RFC5  5985  replication factor C subunit 5
AliasesRFC36
GeneCards (Weizmann)RFC5
Ensembl hg19 (Hinxton)ENSG00000111445 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111445 [Gene_View]  ENSG00000111445 [Sequence]  chr12:118016661-118032237 [Contig_View]  RFC5 [Vega]
ICGC DataPortalENSG00000111445
TCGA cBioPortalRFC5
AceView (NCBI)RFC5
Genatlas (Paris)RFC5
WikiGenes5985
SOURCE (Princeton)RFC5
Genetics Home Reference (NIH)RFC5
Genomic and cartography
GoldenPath hg38 (UCSC)RFC5  -     chr12:118016661-118032237 +  12q24.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RFC5  -     12q24.23   [Description]    (hg19-Feb_2009)
EnsemblRFC5 - 12q24.23 [CytoView hg19]  RFC5 - 12q24.23 [CytoView hg38]
Mapping of homologs : NCBIRFC5 [Mapview hg19]  RFC5 [Mapview hg38]
OMIM600407   
Gene and transcription
Genbank (Entrez)AB208992 AI567945 AK094575 AK290685 AK291107
RefSeq transcript (Entrez)NM_001130112 NM_001130113 NM_001206801 NM_001346815 NM_007370 NM_181578
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RFC5
Cluster EST : UnigeneHs.731908 [ NCBI ]
CGAP (NCI)Hs.731908
Alternative Splicing GalleryENSG00000111445
Gene ExpressionRFC5 [ NCBI-GEO ]   RFC5 [ EBI - ARRAY_EXPRESS ]   RFC5 [ SEEK ]   RFC5 [ MEM ]
Gene Expression Viewer (FireBrowse)RFC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5985
GTEX Portal (Tissue expression)RFC5
Human Protein AtlasENSG00000111445-RFC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40937   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40937  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40937
Splice isoforms : SwissVarP40937
PhosPhoSitePlusP40937
Domains : Interpro (EBI)AAA+_ATPase    ATPase_AAA_core    DNA_pol3_clamp-load_cplx_C    P-loop_NTPase    Rep_factorC_C   
Domain families : Pfam (Sanger)AAA (PF00004)    Rep_fac_C (PF08542)   
Domain families : Pfam (NCBI)pfam00004    pfam08542   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)RFC5
DMDM Disease mutations5985
Blocks (Seattle)RFC5
PDB (SRS)1LFS   
PDB (PDBSum)1LFS   
PDB (IMB)1LFS   
PDB (RSDB)1LFS   
Structural Biology KnowledgeBase1LFS   
SCOP (Structural Classification of Proteins)1LFS   
CATH (Classification of proteins structures)1LFS   
SuperfamilyP40937
Human Protein Atlas [tissue]ENSG00000111445-RFC5 [tissue]
Peptide AtlasP40937
HPRD02677
IPIIPI00031514   IPI00908568   IPI01018037   IPI00925306   IPI00924976   IPI01009845   IPI01010658   IPI01010401   
Protein Interaction databases
DIP (DOE-UCLA)P40937
IntAct (EBI)P40937
FunCoupENSG00000111445
BioGRIDRFC5
STRING (EMBL)RFC5
ZODIACRFC5
Ontologies - Pathways
QuickGOP40937
Ontology : AmiGODNA clamp loader activity  DNA clamp loader activity  protein binding  ATP binding  nucleus  nucleoplasm  DNA replication factor C complex  DNA replication factor C complex  DNA replication  DNA replication  DNA-dependent DNA replication  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  enzyme binding  translesion synthesis  Ctf18 RFC-like complex  telomere maintenance via semi-conservative replication  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  single-stranded DNA-dependent ATPase activity  error-free translesion synthesis  positive regulation of DNA-directed DNA polymerase activity  
Ontology : EGO-EBIDNA clamp loader activity  DNA clamp loader activity  protein binding  ATP binding  nucleus  nucleoplasm  DNA replication factor C complex  DNA replication factor C complex  DNA replication  DNA replication  DNA-dependent DNA replication  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  enzyme binding  translesion synthesis  Ctf18 RFC-like complex  telomere maintenance via semi-conservative replication  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  single-stranded DNA-dependent ATPase activity  error-free translesion synthesis  positive regulation of DNA-directed DNA polymerase activity  
Pathways : KEGGDNA replication    Nucleotide excision repair    Mismatch repair   
NDEx NetworkRFC5
Atlas of Cancer Signalling NetworkRFC5
Wikipedia pathwaysRFC5
Orthology - Evolution
OrthoDB5985
GeneTree (enSembl)ENSG00000111445
Phylogenetic Trees/Animal Genes : TreeFamRFC5
HOVERGENP40937
HOGENOMP40937
Homologs : HomoloGeneRFC5
Homology/Alignments : Family Browser (UCSC)RFC5
Gene fusions - Rearrangements
Fusion : MitelmanCIT/RFC5 [12q24.23/12q24.23]  [t(12;12)(q24;q24)]  
Fusion : MitelmanWSB2/RFC5 [12q24.23/12q24.23]  [t(12;12)(q24;q24)]  
Fusion PortalWSB2 12q24.23 RFC5 12q24.23 LUAD
Fusion : QuiverRFC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRFC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RFC5
dbVarRFC5
ClinVarRFC5
1000_GenomesRFC5 
Exome Variant ServerRFC5
ExAC (Exome Aggregation Consortium)ENSG00000111445
GNOMAD BrowserENSG00000111445
Varsome BrowserRFC5
Genetic variants : HAPMAP5985
Genomic Variants (DGV)RFC5 [DGVbeta]
DECIPHERRFC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRFC5 
Mutations
ICGC Data PortalRFC5 
TCGA Data PortalRFC5 
Broad Tumor PortalRFC5
OASIS PortalRFC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRFC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRFC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RFC5
DgiDB (Drug Gene Interaction Database)RFC5
DoCM (Curated mutations)RFC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RFC5 (select a term)
intoGenRFC5
Cancer3DRFC5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600407   
Orphanet
DisGeNETRFC5
MedgenRFC5
Genetic Testing Registry RFC5
NextProtP40937 [Medical]
TSGene5985
GENETestsRFC5
Target ValidationRFC5
Huge Navigator RFC5 [HugePedia]
snp3D : Map Gene to Disease5985
BioCentury BCIQRFC5
ClinGenRFC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5985
Chemical/Pharm GKB GenePA34342
Clinical trialRFC5
Miscellaneous
canSAR (ICR)RFC5 (select the gene name)
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRFC5
EVEXRFC5
GoPubMedRFC5
iHOPRFC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:35:17 CET 2018

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