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RFC5 (replication factor C subunit 5)

Identity

Alias (NCBI)RFC36
HGNC (Hugo) RFC5
HGNC Alias symbRFC36
HGNC Previous namereplication factor C (activator 1) 5 (36.5kD)
 replication factor C (activator 1) 5, 36.5kDa
LocusID (NCBI) 5985
Atlas_Id 42091
Location 12q24.23  [Link to chromosome band 12q24]
Location_base_pair Starts at 118016661 and ends at 118032237 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CIT (12q24.23) / RFC5 (12q24.23)NFKBIA (14q13.2) / RFC5 (12q24.23)WSB2 (12q24.23) / RFC5 (12q24.23)
WSB2 12q24.23 / RFC5 12q24.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RFC5   9973
Cards
Entrez_Gene (NCBI)RFC5    replication factor C subunit 5
AliasesRFC36
GeneCards (Weizmann)RFC5
Ensembl hg19 (Hinxton)ENSG00000111445 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111445 [Gene_View]  ENSG00000111445 [Sequence]  chr12:118016661-118032237 [Contig_View]  RFC5 [Vega]
ICGC DataPortalENSG00000111445
TCGA cBioPortalRFC5
AceView (NCBI)RFC5
Genatlas (Paris)RFC5
SOURCE (Princeton)RFC5
Genetics Home Reference (NIH)RFC5
Genomic and cartography
GoldenPath hg38 (UCSC)RFC5  -     chr12:118016661-118032237 +  12q24.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RFC5  -     12q24.23   [Description]    (hg19-Feb_2009)
GoldenPathRFC5 - 12q24.23 [CytoView hg19]  RFC5 - 12q24.23 [CytoView hg38]
ImmunoBaseENSG00000111445
Genome Data Viewer NCBIRFC5 [Mapview hg19]  
OMIM600407   
Gene and transcription
Genbank (Entrez)AB208992 AI567945 AK094575 AK290685 AK291107
RefSeq transcript (Entrez)NM_001130112 NM_001130113 NM_001206801 NM_001346815 NM_007370 NM_181578
Consensus coding sequences : CCDS (NCBI)RFC5
Gene ExpressionRFC5 [ NCBI-GEO ]   RFC5 [ EBI - ARRAY_EXPRESS ]   RFC5 [ SEEK ]   RFC5 [ MEM ]
Gene Expression Viewer (FireBrowse)RFC5 [ Firebrowse - Broad ]
GenevisibleExpression of RFC5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5985
GTEX Portal (Tissue expression)RFC5
Human Protein AtlasENSG00000111445-RFC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40937   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40937  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40937
PhosPhoSitePlusP40937
Domains : Interpro (EBI)AAA+_ATPase    ATPase_AAA_core    DNA_pol3_clamp-load_cplx_C    P-loop_NTPase    Rep_factorC_C   
Domain families : Pfam (Sanger)AAA (PF00004)    Rep_fac_C (PF08542)   
Domain families : Pfam (NCBI)pfam00004    pfam08542   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)RFC5
PDB (RSDB)1LFS    6VVO   
PDB Europe1LFS    6VVO   
PDB (PDBSum)1LFS    6VVO   
PDB (IMB)1LFS    6VVO   
Structural Biology KnowledgeBase1LFS    6VVO   
SCOP (Structural Classification of Proteins)1LFS    6VVO   
CATH (Classification of proteins structures)1LFS    6VVO   
SuperfamilyP40937
AlphaFold pdb e-kbP40937   
Human Protein Atlas [tissue]ENSG00000111445-RFC5 [tissue]
HPRD02677
Protein Interaction databases
DIP (DOE-UCLA)P40937
IntAct (EBI)P40937
BioGRIDRFC5
STRING (EMBL)RFC5
ZODIACRFC5
Ontologies - Pathways
QuickGOP40937
Ontology : AmiGODNA binding  DNA clamp loader activity  DNA clamp loader activity  protein binding  ATP binding  nucleus  nucleoplasm  DNA replication factor C complex  DNA replication factor C complex  DNA replication  DNA replication  DNA-dependent DNA replication  DNA repair  DNA repair  transcription-coupled nucleotide-excision repair  base-excision repair, gap-filling  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  single-stranded DNA helicase activity  enzyme binding  translesion synthesis  Ctf18 RFC-like complex  telomere maintenance via semi-conservative replication  DNA duplex unwinding  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  error-free translesion synthesis  positive regulation of DNA-directed DNA polymerase activity  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIDNA binding  DNA clamp loader activity  DNA clamp loader activity  protein binding  ATP binding  nucleus  nucleoplasm  DNA replication factor C complex  DNA replication factor C complex  DNA replication  DNA replication  DNA-dependent DNA replication  DNA repair  DNA repair  transcription-coupled nucleotide-excision repair  base-excision repair, gap-filling  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  single-stranded DNA helicase activity  enzyme binding  translesion synthesis  Ctf18 RFC-like complex  telomere maintenance via semi-conservative replication  DNA duplex unwinding  nucleotide-excision repair, DNA incision  error-prone translesion synthesis  DNA damage response, detection of DNA damage  error-free translesion synthesis  positive regulation of DNA-directed DNA polymerase activity  regulation of signal transduction by p53 class mediator  
Pathways : KEGGDNA replication    Nucleotide excision repair    Mismatch repair   
NDEx NetworkRFC5
Atlas of Cancer Signalling NetworkRFC5
Wikipedia pathwaysRFC5
Orthology - Evolution
OrthoDB5985
GeneTree (enSembl)ENSG00000111445
Phylogenetic Trees/Animal Genes : TreeFamRFC5
Homologs : HomoloGeneRFC5
Homology/Alignments : Family Browser (UCSC)RFC5
Gene fusions - Rearrangements
Fusion : MitelmanCIT/RFC5 [12q24.23/12q24.23]  
Fusion : MitelmanWSB2/RFC5 [12q24.23/12q24.23]  
Fusion : QuiverRFC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRFC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RFC5
dbVarRFC5
ClinVarRFC5
MonarchRFC5
1000_GenomesRFC5 
Exome Variant ServerRFC5
GNOMAD BrowserENSG00000111445
Varsome BrowserRFC5
ACMGRFC5 variants
VarityP40937
Genomic Variants (DGV)RFC5 [DGVbeta]
DECIPHERRFC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRFC5 
Mutations
ICGC Data PortalRFC5 
TCGA Data PortalRFC5 
Broad Tumor PortalRFC5
OASIS PortalRFC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRFC5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRFC5
Mutations and Diseases : HGMDRFC5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRFC5
DgiDB (Drug Gene Interaction Database)RFC5
DoCM (Curated mutations)RFC5
CIViC (Clinical Interpretations of Variants in Cancer)RFC5
Cancer3DRFC5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600407   
Orphanet
DisGeNETRFC5
MedgenRFC5
Genetic Testing Registry RFC5
NextProtP40937 [Medical]
GENETestsRFC5
Target ValidationRFC5
Huge Navigator RFC5 [HugePedia]
ClinGenRFC5
Clinical trials, drugs, therapy
MyCancerGenomeRFC5
Protein Interactions : CTDRFC5
Pharm GKB GenePA34342
PharosP40937
Clinical trialRFC5
Miscellaneous
canSAR (ICR)RFC5
HarmonizomeRFC5
DataMed IndexRFC5
Probes
Litterature
PubMed143 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRFC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:28:44 CEST 2021

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