RFPL3 (ret finger protein like 3)

2015-10-01 Affiliation

Identity

HGNC

RFPL3

LOCATION

22q12.3

LOCUSID

10738

ALIAS

RNF120

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10738
MIM: 605970
HGNC: 9980
Ensembl: ENSG00000128276

Variants:

dbSNP: 10738
ClinVar: 10738
TCGA: ENSG00000128276
COSMIC: RFPL3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000128276	ENST00000249007	O75679
ENSG00000128276	ENST00000397468	O75679

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
18656177	2008	Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development.	17
25481043	2014	Ret finger protein-like 3 promotes tumor cell growth by activating telomerase reverse transcriptase expression in human lung cancer cells.	8
25107902	2014	Identification of RFPL3 protein as a novel E3 ubiquitin ligase modulating the integration activity of human immunodeficiency virus, type 1 preintegration complex using a microtiter plate-based assay.	5
26318425	2015	RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth.	5
29749533	2018	EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in non‑small cell lung cancer cells.	1

Citation

Dessen P

RFPL3 (ret finger protein like 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55479/rfpl3