Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RFX6 (regulatory factor X6)

Identity

Alias_namesRFXDC1
regulatory factor X domain containing 1
regulatory factor X, 6
Alias_symbol (synonym)MGC33442
dJ955L16.1
Other aliasMTCHRS
MTFS
HGNC (Hugo) RFX6
LocusID (NCBI) 222546
Atlas_Id 53133
Location 6q22.1  [Link to chromosome band 6q22]
Location_base_pair Starts at 116877213 and ends at 116932163 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RFX6   21478
Cards
Entrez_Gene (NCBI)RFX6  222546  regulatory factor X6
AliasesMTCHRS; MTFS; RFXDC1; dJ955L16.1
GeneCards (Weizmann)RFX6
Ensembl hg19 (Hinxton)ENSG00000185002 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185002 [Gene_View]  ENSG00000185002 [Sequence]  chr6:116877213-116932163 [Contig_View]  RFX6 [Vega]
ICGC DataPortalENSG00000185002
TCGA cBioPortalRFX6
AceView (NCBI)RFX6
Genatlas (Paris)RFX6
WikiGenes222546
SOURCE (Princeton)RFX6
Genetics Home Reference (NIH)RFX6
Genomic and cartography
GoldenPath hg38 (UCSC)RFX6  -     chr6:116877213-116932163 +  6q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RFX6  -     6q22.1   [Description]    (hg19-Feb_2009)
EnsemblRFX6 - 6q22.1 [CytoView hg19]  RFX6 - 6q22.1 [CytoView hg38]
Mapping of homologs : NCBIRFX6 [Mapview hg19]  RFX6 [Mapview hg38]
OMIM612659   615710   
Gene and transcription
Genbank (Entrez)BC039248 BQ269808 CA842450 CA947154
RefSeq transcript (Entrez)NM_173560
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RFX6
Cluster EST : UnigeneHs.352276 [ NCBI ]
CGAP (NCI)Hs.352276
Alternative Splicing GalleryENSG00000185002
Gene ExpressionRFX6 [ NCBI-GEO ]   RFX6 [ EBI - ARRAY_EXPRESS ]   RFX6 [ SEEK ]   RFX6 [ MEM ]
Gene Expression Viewer (FireBrowse)RFX6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)222546
GTEX Portal (Tissue expression)RFX6
Human Protein AtlasENSG00000185002-RFX6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8HWS3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8HWS3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8HWS3
Splice isoforms : SwissVarQ8HWS3
PhosPhoSitePlusQ8HWS3
Domaine pattern : Prosite (Expaxy)RFX_DBD (PS51526)   
Domains : Interpro (EBI)DNA-bd_RFX    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)RFX_DNA_binding (PF02257)   
Domain families : Pfam (NCBI)pfam02257   
Conserved Domain (NCBI)RFX6
DMDM Disease mutations222546
Blocks (Seattle)RFX6
SuperfamilyQ8HWS3
Human Protein Atlas [tissue]ENSG00000185002-RFX6 [tissue]
Peptide AtlasQ8HWS3
HPRD11490
IPIIPI00219885   
Protein Interaction databases
DIP (DOE-UCLA)Q8HWS3
IntAct (EBI)Q8HWS3
FunCoupENSG00000185002
BioGRIDRFX6
STRING (EMBL)RFX6
ZODIACRFX6
Ontologies - Pathways
QuickGOQ8HWS3
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  type B pancreatic cell differentiation  type B pancreatic cell differentiation  pancreatic A cell differentiation  pancreatic A cell differentiation  pancreatic D cell differentiation  pancreatic D cell differentiation  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleolus  regulation of transcription by RNA polymerase II  endocrine pancreas development  endocrine pancreas development  positive regulation of insulin secretion involved in cellular response to glucose stimulus  glucose homeostasis  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of insulin secretion  regulation of insulin secretion  pancreatic epsilon cell differentiation  pancreatic epsilon cell differentiation  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  type B pancreatic cell differentiation  type B pancreatic cell differentiation  pancreatic A cell differentiation  pancreatic A cell differentiation  pancreatic D cell differentiation  pancreatic D cell differentiation  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleolus  regulation of transcription by RNA polymerase II  endocrine pancreas development  endocrine pancreas development  positive regulation of insulin secretion involved in cellular response to glucose stimulus  glucose homeostasis  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of insulin secretion  regulation of insulin secretion  pancreatic epsilon cell differentiation  pancreatic epsilon cell differentiation  
NDEx NetworkRFX6
Atlas of Cancer Signalling NetworkRFX6
Wikipedia pathwaysRFX6
Orthology - Evolution
OrthoDB222546
GeneTree (enSembl)ENSG00000185002
Phylogenetic Trees/Animal Genes : TreeFamRFX6
HOVERGENQ8HWS3
HOGENOMQ8HWS3
Homologs : HomoloGeneRFX6
Homology/Alignments : Family Browser (UCSC)RFX6
Gene fusions - Rearrangements
Fusion : QuiverRFX6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRFX6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RFX6
dbVarRFX6
ClinVarRFX6
1000_GenomesRFX6 
Exome Variant ServerRFX6
ExAC (Exome Aggregation Consortium)ENSG00000185002
GNOMAD BrowserENSG00000185002
Varsome BrowserRFX6
Genetic variants : HAPMAP222546
Genomic Variants (DGV)RFX6 [DGVbeta]
DECIPHERRFX6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRFX6 
Mutations
ICGC Data PortalRFX6 
TCGA Data PortalRFX6 
Broad Tumor PortalRFX6
OASIS PortalRFX6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRFX6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRFX6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RFX6
DgiDB (Drug Gene Interaction Database)RFX6
DoCM (Curated mutations)RFX6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RFX6 (select a term)
intoGenRFX6
Cancer3DRFX6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612659    615710   
Orphanet20883   
DisGeNETRFX6
MedgenRFX6
Genetic Testing Registry RFX6
NextProtQ8HWS3 [Medical]
TSGene222546
GENETestsRFX6
Target ValidationRFX6
Huge Navigator RFX6 [HugePedia]
snp3D : Map Gene to Disease222546
BioCentury BCIQRFX6
ClinGenRFX6 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD222546
Chemical/Pharm GKB GenePA162401254
Clinical trialRFX6
Miscellaneous
canSAR (ICR)RFX6 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRFX6
EVEXRFX6
GoPubMedRFX6
iHOPRFX6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 6 11:35:20 CET 2018

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