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RGL2 (ral guanine nucleotide dissociation stimulator like 2)

Identity

Alias_namesRAB2L
RAB2
Alias_symbol (synonym)KE1.5
HKE1.5
Other alias
HGNC (Hugo) RGL2
LocusID (NCBI) 5863
Atlas_Id 41976
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 33291654 and ends at 33299388 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DAP (5p15.2) / RGL2 (6p21.32)RGL2 (6p21.32) / PTMS (12p13.31)RGL2 (6p21.32) / RGL2 (6p21.32)
DAP 5p15.2 / RGL2 6p21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;6)(p15;p21) DAP/RGL2


External links

Nomenclature
HGNC (Hugo)RGL2   9769
Cards
Entrez_Gene (NCBI)RGL2  5863  ral guanine nucleotide dissociation stimulator like 2
AliasesHKE1.5; KE1.5; RAB2L
GeneCards (Weizmann)RGL2
Ensembl hg19 (Hinxton)ENSG00000237441 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000237441 [Gene_View]  ENSG00000237441 [Sequence]  chr6:33291654-33299388 [Contig_View]  RGL2 [Vega]
ICGC DataPortalENSG00000237441
TCGA cBioPortalRGL2
AceView (NCBI)RGL2
Genatlas (Paris)RGL2
WikiGenes5863
SOURCE (Princeton)RGL2
Genetics Home Reference (NIH)RGL2
Genomic and cartography
GoldenPath hg38 (UCSC)RGL2  -     chr6:33291654-33299388 -  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RGL2  -     6p21.32   [Description]    (hg19-Feb_2009)
EnsemblRGL2 - 6p21.32 [CytoView hg19]  RGL2 - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBIRGL2 [Mapview hg19]  RGL2 [Mapview hg38]
OMIM602306   
Gene and transcription
Genbank (Entrez)AB012295 AK095967 AK294442 AL050259 BC000316
RefSeq transcript (Entrez)NM_001243738 NM_004761
RefSeq genomic (Entrez)NC_000006 NT_113891 NT_167245 NT_167247 NT_167248
Consensus coding sequences : CCDS (NCBI)RGL2
Cluster EST : UnigeneHs.509622 [ NCBI ]
CGAP (NCI)Hs.509622
Alternative Splicing GalleryENSG00000237441
Gene ExpressionRGL2 [ NCBI-GEO ]   RGL2 [ EBI - ARRAY_EXPRESS ]   RGL2 [ SEEK ]   RGL2 [ MEM ]
Gene Expression Viewer (FireBrowse)RGL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5863
GTEX Portal (Tissue expression)RGL2
Human Protein AtlasENSG00000237441-RGL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15211   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15211  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15211
Splice isoforms : SwissVarO15211
PhosPhoSitePlusO15211
Domaine pattern : Prosite (Expaxy)RA (PS50200)    RASGEF (PS00720)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)   
Domains : Interpro (EBI)RA_dom    Ras-like_Gua-exchang_fac_N    Ras_G-nucl-exch_fac_CS    Ras_GEF_dom_sf    RASGEF_cat_dom    RASGEF_cat_dom_sf    RGL2    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)RA (PF00788)    RasGEF (PF00617)    RasGEF_N (PF00618)   
Domain families : Pfam (NCBI)pfam00788    pfam00617    pfam00618   
Domain families : Smart (EMBL)RA (SM00314)  RasGEF (SM00147)  RasGEFN (SM00229)  
Conserved Domain (NCBI)RGL2
DMDM Disease mutations5863
Blocks (Seattle)RGL2
SuperfamilyO15211
Human Protein Atlas [tissue]ENSG00000237441-RGL2 [tissue]
Peptide AtlasO15211
HPRD03810
IPIIPI00005656   IPI00908923   IPI00178959   IPI00186526   
Protein Interaction databases
DIP (DOE-UCLA)O15211
IntAct (EBI)O15211
FunCoupENSG00000237441
BioGRIDRGL2
STRING (EMBL)RGL2
ZODIACRGL2
Ontologies - Pathways
QuickGOO15211
Ontology : AmiGORas guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  cellular_component  intracellular  Ras protein signal transduction  negative regulation of cardiac muscle cell apoptotic process  positive regulation of phosphatidylinositol 3-kinase signaling  regulation of Ral protein signal transduction  
Ontology : EGO-EBIRas guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  cellular_component  intracellular  Ras protein signal transduction  negative regulation of cardiac muscle cell apoptotic process  positive regulation of phosphatidylinositol 3-kinase signaling  regulation of Ral protein signal transduction  
Pathways : KEGGRas signaling pathway   
NDEx NetworkRGL2
Atlas of Cancer Signalling NetworkRGL2
Wikipedia pathwaysRGL2
Orthology - Evolution
OrthoDB5863
GeneTree (enSembl)ENSG00000237441
Phylogenetic Trees/Animal Genes : TreeFamRGL2
HOVERGENO15211
HOGENOMO15211
Homologs : HomoloGeneRGL2
Homology/Alignments : Family Browser (UCSC)RGL2
Gene fusions - Rearrangements
Fusion : MitelmanDAP/RGL2 [5p15.2/6p21.32]  [t(5;6)(p15;p21)]  
Fusion PortalDAP 5p15.2 RGL2 6p21.32 PRAD
Fusion : QuiverRGL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRGL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RGL2
dbVarRGL2
ClinVarRGL2
1000_GenomesRGL2 
Exome Variant ServerRGL2
ExAC (Exome Aggregation Consortium)ENSG00000237441
GNOMAD BrowserENSG00000237441
Varsome BrowserRGL2
Genetic variants : HAPMAP5863
Genomic Variants (DGV)RGL2 [DGVbeta]
DECIPHERRGL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRGL2 
Mutations
ICGC Data PortalRGL2 
TCGA Data PortalRGL2 
Broad Tumor PortalRGL2
OASIS PortalRGL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRGL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRGL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RGL2
DgiDB (Drug Gene Interaction Database)RGL2
DoCM (Curated mutations)RGL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RGL2 (select a term)
intoGenRGL2
Cancer3DRGL2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602306   
Orphanet
DisGeNETRGL2
MedgenRGL2
Genetic Testing Registry RGL2
NextProtO15211 [Medical]
TSGene5863
GENETestsRGL2
Target ValidationRGL2
Huge Navigator RGL2 [HugePedia]
snp3D : Map Gene to Disease5863
BioCentury BCIQRGL2
ClinGenRGL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5863
Chemical/Pharm GKB GenePA34120
Clinical trialRGL2
Miscellaneous
canSAR (ICR)RGL2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRGL2
EVEXRGL2
GoPubMedRGL2
iHOPRGL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:35:22 CET 2018

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