RGN (regucalcin)

2009-11-01  

Identity

HGNC
LOCATION
Xp11.3
LOCUSID
ALIAS
GNL,HEL-S-41,RC,SMP30

Other Information

Locus ID:

NCBI: 9104
MIM: 300212
HGNC: 9989
Ensembl: ENSG00000130988

Variants:

dbSNP: 9104
ClinVar: 9104
TCGA: ENSG00000130988
COSMIC: RGN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130988ENST00000336169Q15493
ENSG00000130988ENST00000336169V9HWF8
ENSG00000130988ENST00000352078Q15493
ENSG00000130988ENST00000352078V9HWF8
ENSG00000130988ENST00000397180Q15493
ENSG00000130988ENST00000397180V9HWF8
ENSG00000130988ENST00000457380Q15493

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Pentose phosphate pathwayKEGGko00030
Ascorbate and aldarate metabolismKEGGko00053
Pentose phosphate pathwayKEGGhsa00030
Ascorbate and aldarate metabolismKEGGhsa00053
Metabolic pathwaysKEGGhsa01100
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382465192024Regucalcin downregulation in human cancer.1
382465192024Regucalcin downregulation in human cancer.1
364425912023Functional pleiotropy of calcium binding protein Regucalcin in signaling and diseases.2
366562032023Senescence in oral lichen planus as assessed by the immunohistochemical evaluation of senescence marker protein-30 (Regucalcin).2
370015962023The inflammatory macrophages repress the growth of bone metastatic human prostate cancer cells via TNF-α and IL-6 signaling: Involvement of cell signaling regulator regucalcin.3
374687922023Uroplakin 1a Interacts with Regucalcin and Proteasome Subunit Beta 1.0
364425912023Functional pleiotropy of calcium binding protein Regucalcin in signaling and diseases.2
366562032023Senescence in oral lichen planus as assessed by the immunohistochemical evaluation of senescence marker protein-30 (Regucalcin).2
370015962023The inflammatory macrophages repress the growth of bone metastatic human prostate cancer cells via TNF-α and IL-6 signaling: Involvement of cell signaling regulator regucalcin.3
374687922023Uroplakin 1a Interacts with Regucalcin and Proteasome Subunit Beta 1.0
353658502022Overexpression of regucalcin blocks the migration, invasion, and bone metastatic activity of human prostate cancer cells: Crosstalk between cancer cells and bone cells.1
356159752022Senescence marker protein30 protects lens epithelial cells against oxidative damage by restoring mitochondrial function.3
353658502022Overexpression of regucalcin blocks the migration, invasion, and bone metastatic activity of human prostate cancer cells: Crosstalk between cancer cells and bone cells.1
356159752022Senescence marker protein30 protects lens epithelial cells against oxidative damage by restoring mitochondrial function.3
336528812021Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals.3

Citation

Dessen P

RGN (regucalcin)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51174/rgn