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RGS12 (regulator of G-protein signaling 12)

Identity

Alias_namesregulator of G-protein signalling 12
Other alias-
HGNC (Hugo) RGS12
LocusID (NCBI) 6002
Atlas_Id 42100
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 3315874 and ends at 3433904 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BAALC (8q22.3) / RGS12 (4p16.3)RGS12 (4p16.3) / HTT (4p16.3)RGS12 (4p16.3) / RGS12 (4p16.3)
RGS12 (4p16.3) / USP2 (11q23.3)RGS12 (4p16.3) / ZNF587 (19q13.43)RGS12 4p16.3 / USP2 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RGS12   9994
Cards
Entrez_Gene (NCBI)RGS12  6002  regulator of G-protein signaling 12
Aliases
GeneCards (Weizmann)RGS12
Ensembl hg19 (Hinxton)ENSG00000159788 [Gene_View]  chr4:3315874-3433904 [Contig_View]  RGS12 [Vega]
Ensembl hg38 (Hinxton)ENSG00000159788 [Gene_View]  chr4:3315874-3433904 [Contig_View]  RGS12 [Vega]
ICGC DataPortalENSG00000159788
TCGA cBioPortalRGS12
AceView (NCBI)RGS12
Genatlas (Paris)RGS12
WikiGenes6002
SOURCE (Princeton)RGS12
Genetics Home Reference (NIH)RGS12
Genomic and cartography
GoldenPath hg19 (UCSC)RGS12  -     chr4:3315874-3433904 +  4p16.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RGS12  -     4p16.3   [Description]    (hg38-Dec_2013)
EnsemblRGS12 - 4p16.3 [CytoView hg19]  RGS12 - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBIRGS12 [Mapview hg19]  RGS12 [Mapview hg38]
OMIM602512   
Gene and transcription
Genbank (Entrez)AF030109 AF030110 AF030111 AF030112 AF035152
RefSeq transcript (Entrez)NM_002926 NM_198227 NM_198229 NM_198230 NM_198430 NM_198432 NM_198587
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_029903 NT_006051 NW_004929314
Consensus coding sequences : CCDS (NCBI)RGS12
Cluster EST : UnigeneHs.527061 [ NCBI ]
CGAP (NCI)Hs.527061
Alternative Splicing GalleryENSG00000159788
Gene ExpressionRGS12 [ NCBI-GEO ]   RGS12 [ EBI - ARRAY_EXPRESS ]   RGS12 [ SEEK ]   RGS12 [ MEM ]
Gene Expression Viewer (FireBrowse)RGS12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6002
GTEX Portal (Tissue expression)RGS12
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14924   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14924  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14924
Splice isoforms : SwissVarO14924
PhosPhoSitePlusO14924
Domaine pattern : Prosite (Expaxy)GOLOCO (PS50877)    PDZ (PS50106)    PID (PS01179)    RBD (PS50898)    RGS (PS50132)   
Domains : Interpro (EBI)GoLoco_motif    PDZ    PH_dom-like    PTB/PI_dom    Raf-like_ras-bd    RGS    RGS_subdom1    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)GoLoco (PF02188)    PDZ (PF00595)    RBD (PF02196)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam02188    pfam00595    pfam02196    pfam00615   
Domain families : Smart (EMBL)GoLoco (SM00390)  PDZ (SM00228)  PTB (SM00462)  RBD (SM00455)  RGS (SM00315)  
Conserved Domain (NCBI)RGS12
DMDM Disease mutations6002
Blocks (Seattle)RGS12
PDB (SRS)2EBZ    2KV8   
PDB (PDBSum)2EBZ    2KV8   
PDB (IMB)2EBZ    2KV8   
PDB (RSDB)2EBZ    2KV8   
Structural Biology KnowledgeBase2EBZ    2KV8   
SCOP (Structural Classification of Proteins)2EBZ    2KV8   
CATH (Classification of proteins structures)2EBZ    2KV8   
SuperfamilyO14924
Human Protein AtlasENSG00000159788
Peptide AtlasO14924
HPRD03943
IPIIPI00024714   IPI00219104   IPI00219105   IPI00219106   IPI01013960   IPI00922699   IPI00965126   IPI00965444   
Protein Interaction databases
DIP (DOE-UCLA)O14924
IntAct (EBI)O14924
FunCoupENSG00000159788
BioGRIDRGS12
STRING (EMBL)RGS12
ZODIACRGS12
Ontologies - Pathways
QuickGOO14924
Ontology : AmiGOcondensed nuclear chromosome  G-protein alpha-subunit binding  receptor signaling protein activity  GTPase activator activity  nucleus  cytoplasm  cytoplasm  cytosol  plasma membrane  transcription, DNA-templated  signal transduction  regulation of G-protein coupled receptor protein signaling pathway  nuclear matrix  cell junction  dendrite  GTPase regulator activity  termination of G-protein coupled receptor signaling pathway  neuronal cell body  protein complex  positive regulation of GTPase activity  synapse  apical dendrite  
Ontology : EGO-EBIcondensed nuclear chromosome  G-protein alpha-subunit binding  receptor signaling protein activity  GTPase activator activity  nucleus  cytoplasm  cytoplasm  cytosol  plasma membrane  transcription, DNA-templated  signal transduction  regulation of G-protein coupled receptor protein signaling pathway  nuclear matrix  cell junction  dendrite  GTPase regulator activity  termination of G-protein coupled receptor signaling pathway  neuronal cell body  protein complex  positive regulation of GTPase activity  synapse  apical dendrite  
NDEx NetworkRGS12
Atlas of Cancer Signalling NetworkRGS12
Wikipedia pathwaysRGS12
Orthology - Evolution
OrthoDB6002
GeneTree (enSembl)ENSG00000159788
Phylogenetic Trees/Animal Genes : TreeFamRGS12
HOVERGENO14924
HOGENOMO14924
Homologs : HomoloGeneRGS12
Homology/Alignments : Family Browser (UCSC)RGS12
Gene fusions - Rearrangements
Fusion : MitelmanRGS12/USP2 [4p16.3/11q23.3]  
Fusion: TCGARGS12 4p16.3 USP2 11q23.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRGS12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RGS12
dbVarRGS12
ClinVarRGS12
1000_GenomesRGS12 
Exome Variant ServerRGS12
ExAC (Exome Aggregation Consortium)RGS12 (select the gene name)
Genetic variants : HAPMAP6002
Genomic Variants (DGV)RGS12 [DGVbeta]
DECIPHER (Syndromes)4:3315874-3433904  ENSG00000159788
CONAN: Copy Number AnalysisRGS12 
Mutations
ICGC Data PortalRGS12 
TCGA Data PortalRGS12 
Broad Tumor PortalRGS12
OASIS PortalRGS12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRGS12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRGS12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RGS12
DgiDB (Drug Gene Interaction Database)RGS12
DoCM (Curated mutations)RGS12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RGS12 (select a term)
intoGenRGS12
Cancer3DRGS12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602512   
Orphanet
MedgenRGS12
Genetic Testing Registry RGS12
NextProtO14924 [Medical]
TSGene6002
GENETestsRGS12
Huge Navigator RGS12 [HugePedia]
snp3D : Map Gene to Disease6002
BioCentury BCIQRGS12
ClinGenRGS12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6002
Chemical/Pharm GKB GenePA34364
Clinical trialRGS12
Miscellaneous
canSAR (ICR)RGS12 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRGS12
EVEXRGS12
GoPubMedRGS12
iHOPRGS12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:24:56 CET 2017

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