RGS14 (regulator of G protein signaling 14)

2007-04-01  

Identity

HGNC
RGS14
LOCATION
5q35.3
LOCUSID
10636
ALIAS
-

Other Information

Locus ID:

NCBI: 10636
MIM: 602513
HGNC: 9996
Ensembl: ENSG00000169220

Variants:

dbSNP: 10636
ClinVar: 10636
TCGA: ENSG00000169220
COSMIC: RGS14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169220ENST00000408923O43566
ENSG00000169220ENST00000511890H0Y8W3

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198787192010RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways.36
218807392011G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells.16
159176562005RGS14 is a microtubule-associated protein.10
287762002018Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain.6
206278712010Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.5
232554342013The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins.5
302178072018Genetic Variants Associated with Circulating Fibroblast Growth Factor 23.4
269878132016Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.3
208420662010Regulator of G-protein signaling 14 protein modulates Ca²+ influx through Cav1 channels.2
196368372007Backbone and sidechain 1H, 13C and 15N resonance assignments of the RGS domain from human RGS14.0

Citation

Dessen P

RGS14 (regulator of G protein signaling 14)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47500/rgs14