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RGS14 (regulator of G-protein signaling 14)

Identity

Alias_namesregulator of G-protein signalling 14
Other alias-
HGNC (Hugo) RGS14
LocusID (NCBI) 10636
Atlas_Id 47500
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 176784844 and ends at 176799599 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RGS14   9996
Cards
Entrez_Gene (NCBI)RGS14  10636  regulator of G-protein signaling 14
Aliases
GeneCards (Weizmann)RGS14
Ensembl hg19 (Hinxton)ENSG00000169220 [Gene_View]  chr5:176784844-176799599 [Contig_View]  RGS14 [Vega]
Ensembl hg38 (Hinxton)ENSG00000169220 [Gene_View]  chr5:176784844-176799599 [Contig_View]  RGS14 [Vega]
ICGC DataPortalENSG00000169220
TCGA cBioPortalRGS14
AceView (NCBI)RGS14
Genatlas (Paris)RGS14
WikiGenes10636
SOURCE (Princeton)RGS14
Genetics Home Reference (NIH)RGS14
Genomic and cartography
GoldenPath hg19 (UCSC)RGS14  -     chr5:176784844-176799599 +  5q35.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RGS14  -     5q35.3   [Description]    (hg38-Dec_2013)
EnsemblRGS14 - 5q35.3 [CytoView hg19]  RGS14 - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBIRGS14 [Mapview hg19]  RGS14 [Mapview hg38]
OMIM602513   
Gene and transcription
Genbank (Entrez)AF037194 AF037195 AF493936 AI623584 AK098150
RefSeq transcript (Entrez)NM_006480
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_023133 NW_004929325
Consensus coding sequences : CCDS (NCBI)RGS14
Cluster EST : UnigeneHs.9347 [ NCBI ]
CGAP (NCI)Hs.9347
Alternative Splicing GalleryENSG00000169220
Gene ExpressionRGS14 [ NCBI-GEO ]   RGS14 [ EBI - ARRAY_EXPRESS ]   RGS14 [ SEEK ]   RGS14 [ MEM ]
Gene Expression Viewer (FireBrowse)RGS14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10636
GTEX Portal (Tissue expression)RGS14
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43566   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43566  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43566
Splice isoforms : SwissVarO43566
PhosPhoSitePlusO43566
Domaine pattern : Prosite (Expaxy)GOLOCO (PS50877)    RBD (PS50898)    RGS (PS50132)   
Domains : Interpro (EBI)GoLoco_motif    Raf-like_ras-bd    RGS    RGS14    RGS_subdom1    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)RBD (PF02196)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam02196    pfam00615   
Domain families : Smart (EMBL)GoLoco (SM00390)  RBD (SM00455)  RGS (SM00315)  
Conserved Domain (NCBI)RGS14
DMDM Disease mutations10636
Blocks (Seattle)RGS14
PDB (SRS)2JNU    2OM2    2XNS    3ONW    3QI2   
PDB (PDBSum)2JNU    2OM2    2XNS    3ONW    3QI2   
PDB (IMB)2JNU    2OM2    2XNS    3ONW    3QI2   
PDB (RSDB)2JNU    2OM2    2XNS    3ONW    3QI2   
Structural Biology KnowledgeBase2JNU    2OM2    2XNS    3ONW    3QI2   
SCOP (Structural Classification of Proteins)2JNU    2OM2    2XNS    3ONW    3QI2   
CATH (Classification of proteins structures)2JNU    2OM2    2XNS    3ONW    3QI2   
SuperfamilyO43566
Human Protein AtlasENSG00000169220
Peptide AtlasO43566
HPRD03944
IPIIPI00943204   IPI00914936   IPI00219126   IPI00873546   
Protein Interaction databases
DIP (DOE-UCLA)O43566
IntAct (EBI)O43566
FunCoupENSG00000169220
BioGRIDRGS14
STRING (EMBL)RGS14
ZODIACRGS14
Ontologies - Pathways
QuickGOO43566
Ontology : AmiGOspindle pole  G-protein alpha-subunit binding  receptor signaling protein activity  GDP-dissociation inhibitor activity  GTPase activator activity  protein binding  nucleus  cytoplasm  cytoplasm  centrosome  spindle  microtubule  plasma membrane  plasma membrane  nucleocytoplasmic transport  response to oxidative stress  spindle organization  chromosome segregation  mitotic nuclear division  learning  long-term memory  microtubule binding  regulation of G-protein coupled receptor protein signaling pathway  visual learning  zygote asymmetric cell division  postsynaptic density  nuclear body  PML body  protein kinase binding  cell junction  receptor signaling complex scaffold activity  dendrite  negative regulation of synaptic plasticity  GTPase activating protein binding  intracellular signal transduction  dendritic spine  negative regulation of MAP kinase activity  positive regulation of GTPase activity  regulation of DNA-templated transcription in response to stress  postsynaptic membrane  platelet-derived growth factor receptor signaling pathway  positive regulation of neurogenesis  cell division  long-term synaptic potentiation  negative regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIspindle pole  G-protein alpha-subunit binding  receptor signaling protein activity  GDP-dissociation inhibitor activity  GTPase activator activity  protein binding  nucleus  cytoplasm  cytoplasm  centrosome  spindle  microtubule  plasma membrane  plasma membrane  nucleocytoplasmic transport  response to oxidative stress  spindle organization  chromosome segregation  mitotic nuclear division  learning  long-term memory  microtubule binding  regulation of G-protein coupled receptor protein signaling pathway  visual learning  zygote asymmetric cell division  postsynaptic density  nuclear body  PML body  protein kinase binding  cell junction  receptor signaling complex scaffold activity  dendrite  negative regulation of synaptic plasticity  GTPase activating protein binding  intracellular signal transduction  dendritic spine  negative regulation of MAP kinase activity  positive regulation of GTPase activity  regulation of DNA-templated transcription in response to stress  postsynaptic membrane  platelet-derived growth factor receptor signaling pathway  positive regulation of neurogenesis  cell division  long-term synaptic potentiation  negative regulation of ERK1 and ERK2 cascade  
Pathways : KEGGRap1 signaling pathway   
NDEx NetworkRGS14
Atlas of Cancer Signalling NetworkRGS14
Wikipedia pathwaysRGS14
Orthology - Evolution
OrthoDB10636
GeneTree (enSembl)ENSG00000169220
Phylogenetic Trees/Animal Genes : TreeFamRGS14
HOVERGENO43566
HOGENOMO43566
Homologs : HomoloGeneRGS14
Homology/Alignments : Family Browser (UCSC)RGS14
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRGS14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RGS14
dbVarRGS14
ClinVarRGS14
1000_GenomesRGS14 
Exome Variant ServerRGS14
ExAC (Exome Aggregation Consortium)RGS14 (select the gene name)
Genetic variants : HAPMAP10636
Genomic Variants (DGV)RGS14 [DGVbeta]
DECIPHER (Syndromes)5:176784844-176799599  ENSG00000169220
CONAN: Copy Number AnalysisRGS14 
Mutations
ICGC Data PortalRGS14 
TCGA Data PortalRGS14 
Broad Tumor PortalRGS14
OASIS PortalRGS14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRGS14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRGS14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RGS14
DgiDB (Drug Gene Interaction Database)RGS14
DoCM (Curated mutations)RGS14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RGS14 (select a term)
intoGenRGS14
Cancer3DRGS14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602513   
Orphanet
MedgenRGS14
Genetic Testing Registry RGS14
NextProtO43566 [Medical]
TSGene10636
GENETestsRGS14
Huge Navigator RGS14 [HugePedia]
snp3D : Map Gene to Disease10636
BioCentury BCIQRGS14
ClinGenRGS14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10636
Chemical/Pharm GKB GenePA34366
Clinical trialRGS14
Miscellaneous
canSAR (ICR)RGS14 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRGS14
EVEXRGS14
GoPubMedRGS14
iHOPRGS14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:24:57 CET 2017

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