RGS19 (regulator of G protein signaling 19)

2007-04-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
GAIP,RGSGAIP
FUSION GENES

Other Information

Locus ID:

NCBI: 10287
MIM: 605071
HGNC: 13735
Ensembl: ENSG00000171700

Variants:

dbSNP: 10287
ClinVar: 10287
TCGA: ENSG00000171700
COSMIC: RGS19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171700ENST00000332298P49795
ENSG00000171700ENST00000395042P49795

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD
PA452618opioidsChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
204680642010Association study of 182 candidate genes in anorexia nervosa.30
237990312013Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls.24
153562682004GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling.23
183600382008Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension.23
234164642013RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras.15
2479330220145-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19.7
217051352011RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling.6
125074752003Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19.5
220450622012Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum.1
261165292015RGS19 converts iron deprivation stress into a growth-inhibitory signal.0

Citation

Dessen P

RGS19 (regulator of G protein signaling 19)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46896/rgs19