RGS20 (regulator of G protein signaling 20)

2007-04-01  

Identity

HGNC
RGS20
LOCATION
8q11.23
LOCUSID
8601
ALIAS
RGSZ1,ZGAP1,g(z)GAP,gz-GAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8601
MIM: 607193
HGNC: 14600
Ensembl: ENSG00000147509

Variants:

dbSNP: 8601
ClinVar: 8601
TCGA: ENSG00000147509
COSMIC: RGS20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147509ENST00000276500O76081
ENSG00000147509ENST00000276500H9NIM5
ENSG00000147509ENST00000297313O76081
ENSG00000147509ENST00000344277O76081
ENSG00000147509ENST00000517659E5RGA3
ENSG00000147509ENST00000522225B3KSW4
ENSG00000147509ENST00000523280E5RH54

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
171265292007RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling.24
183600382008Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension.23
123796572002Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling.11
274958752016Regulator of G protein signaling 20 enhances cancer cell aggregation, migration, invasion and adhesion.8
294844202018lncRNA NEAT1 promotes cell proliferation and invasion by regulating miR‑365/RGS20 in oral squamous cell carcinoma.7
206278712010Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.5
282377012017Regulator of G protein signaling 20 correlates with clinicopathological features and prognosis in triple-negative breast cancer.3
285029232017G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].3
1487213620041H, 13C and 15N resonance assignments of human RGSZ1.0
312121302019Regulator of G protein signaling 20 promotes proliferation and migration in bladder cancer via NF-κB signaling.0

Citation

Dessen P

RGS20 (regulator of G protein signaling 20)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47000/rgs20