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RGS3 (regulator of G protein signaling 3)

Identity

Alias_namesregulator of G-protein signalling 3
Alias_symbol (synonym)C2PA
FLJ20370
PDZ-RGS3
Other aliasRGP3
HGNC (Hugo) RGS3
LocusID (NCBI) 5998
Atlas_Id 42103
Location 9q32  [Link to chromosome band 9q32]
Location_base_pair Starts at 113536477 and ends at 113597743 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DPYSL2 (8p21.2) / RGS3 (9q32)LMO4 (1p22.3) / RGS3 (9q32)RC3H2 (9q33.2) / RGS3 (9q32)
RGS3 (9q32) / ABCA1 (9q31.1)RGS3 (9q32) / AFF3 (2q11.2)RGS3 (9q32) / BSPRY (9q32)
RGS3 (9q32) / GOLM1 (9q21.33)RGS3 (9q32) / MIER3 (5q11.2)SEMA4D (9q22.2) / RGS3 (9q32)
RGS3 9q32 / ABCA1 9q31.1RGS3 9q32 / BSPRY 9q32RGS3 9q32 / MIER3 5q11.2
SEMA4D 9q22.2 / RGS3 9q32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)RGS3   9999
Cards
Entrez_Gene (NCBI)RGS3  5998  regulator of G protein signaling 3
AliasesC2PA; RGP3
GeneCards (Weizmann)RGS3
Ensembl hg19 (Hinxton)ENSG00000138835 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138835 [Gene_View]  chr9:113536477-113597743 [Contig_View]  RGS3 [Vega]
ICGC DataPortalENSG00000138835
TCGA cBioPortalRGS3
AceView (NCBI)RGS3
Genatlas (Paris)RGS3
WikiGenes5998
SOURCE (Princeton)RGS3
Genetics Home Reference (NIH)RGS3
Genomic and cartography
GoldenPath hg38 (UCSC)RGS3  -     chr9:113536477-113597743 +  9q32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RGS3  -     9q32   [Description]    (hg19-Feb_2009)
EnsemblRGS3 - 9q32 [CytoView hg19]  RGS3 - 9q32 [CytoView hg38]
Mapping of homologs : NCBIRGS3 [Mapview hg19]  RGS3 [Mapview hg38]
OMIM602189   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001276260 NM_001276261 NM_001276262 NM_001282922 NM_001282923 NM_001322214 NM_001322215 NM_017790 NM_130795 NM_134427 NM_144488 NM_144489
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RGS3
Cluster EST : UnigeneHs.655276 [ NCBI ]
CGAP (NCI)Hs.655276
Alternative Splicing GalleryENSG00000138835
Gene ExpressionRGS3 [ NCBI-GEO ]   RGS3 [ EBI - ARRAY_EXPRESS ]   RGS3 [ SEEK ]   RGS3 [ MEM ]
Gene Expression Viewer (FireBrowse)RGS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5998
GTEX Portal (Tissue expression)RGS3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49796   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49796  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49796
Splice isoforms : SwissVarP49796
PhosPhoSitePlusP49796
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PDZ (PS50106)    RGS (PS50132)   
Domains : Interpro (EBI)C2_dom    PDZ    PH_dom-like    RGS    RGS_subdom1   
Domain families : Pfam (Sanger)C2 (PF00168)    PDZ (PF00595)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00168    pfam00595    pfam00615   
Domain families : Smart (EMBL)C2 (SM00239)  PDZ (SM00228)  RGS (SM00315)  
Conserved Domain (NCBI)RGS3
DMDM Disease mutations5998
Blocks (Seattle)RGS3
PDB (SRS)2F5Y    2OJ4    3FBK   
PDB (PDBSum)2F5Y    2OJ4    3FBK   
PDB (IMB)2F5Y    2OJ4    3FBK   
PDB (RSDB)2F5Y    2OJ4    3FBK   
Structural Biology KnowledgeBase2F5Y    2OJ4    3FBK   
SCOP (Structural Classification of Proteins)2F5Y    2OJ4    3FBK   
CATH (Classification of proteins structures)2F5Y    2OJ4    3FBK   
SuperfamilyP49796
Human Protein AtlasENSG00000138835
Peptide AtlasP49796
HPRD03720
IPIIPI00181533   IPI00418780   IPI00328216   IPI00385923   IPI00604741   IPI00902612   IPI00445778   IPI00168858   IPI00645434   IPI00473078   IPI00945951   IPI00945587   IPI00946312   
Protein Interaction databases
DIP (DOE-UCLA)P49796
IntAct (EBI)P49796
FunCoupENSG00000138835
BioGRIDRGS3
STRING (EMBL)RGS3
ZODIACRGS3
Ontologies - Pathways
QuickGOP49796
Ontology : AmiGOinactivation of MAPK activity  GTPase activator activity  protein binding  nucleoplasm  cytosol  plasma membrane  regulation of G-protein coupled receptor protein signaling pathway  positive regulation of GTPase activity  
Ontology : EGO-EBIinactivation of MAPK activity  GTPase activator activity  protein binding  nucleoplasm  cytosol  plasma membrane  regulation of G-protein coupled receptor protein signaling pathway  positive regulation of GTPase activity  
Pathways : KEGGAxon guidance   
NDEx NetworkRGS3
Atlas of Cancer Signalling NetworkRGS3
Wikipedia pathwaysRGS3
Orthology - Evolution
OrthoDB5998
GeneTree (enSembl)ENSG00000138835
Phylogenetic Trees/Animal Genes : TreeFamRGS3
HOVERGENP49796
HOGENOMP49796
Homologs : HomoloGeneRGS3
Homology/Alignments : Family Browser (UCSC)RGS3
Gene fusions - Rearrangements
Fusion : MitelmanRC3H2/RGS3 [9q33.2/9q32]  [t(9;9)(q32;q33)]  
Fusion : MitelmanRGS3/ABCA1 [9q32/9q31.1]  [t(9;9)(q31;q32)]  
Fusion : MitelmanRGS3/MIER3 [9q32/5q11.2]  [t(5;9)(q11;q32)]  
Fusion : MitelmanSEMA4D/RGS3 [9q22.2/9q32]  [t(9;9)(q22;q32)]  
Fusion: TCGARGS3 9q32 ABCA1 9q31.1 PRAD
Fusion: TCGARGS3 9q32 BSPRY 9q32 LUAD
Fusion: TCGARGS3 9q32 MIER3 5q11.2 BRCA
Fusion: TCGASEMA4D 9q22.2 RGS3 9q32 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRGS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RGS3
dbVarRGS3
ClinVarRGS3
1000_GenomesRGS3 
Exome Variant ServerRGS3
ExAC (Exome Aggregation Consortium)RGS3 (select the gene name)
Genetic variants : HAPMAP5998
Genomic Variants (DGV)RGS3 [DGVbeta]
DECIPHERRGS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRGS3 
Mutations
ICGC Data PortalRGS3 
TCGA Data PortalRGS3 
Broad Tumor PortalRGS3
OASIS PortalRGS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRGS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRGS3
intOGen PortalRGS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch RGS3
DgiDB (Drug Gene Interaction Database)RGS3
DoCM (Curated mutations)RGS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RGS3 (select a term)
intoGenRGS3
Cancer3DRGS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602189   
Orphanet
MedgenRGS3
Genetic Testing Registry RGS3
NextProtP49796 [Medical]
TSGene5998
GENETestsRGS3
Huge Navigator RGS3 [HugePedia]
snp3D : Map Gene to Disease5998
BioCentury BCIQRGS3
ClinGenRGS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5998
Chemical/Pharm GKB GenePA34374
Clinical trialRGS3
Miscellaneous
canSAR (ICR)RGS3 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRGS3
EVEXRGS3
GoPubMedRGS3
iHOPRGS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:34:54 CEST 2017

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