RGS3 (regulator of G protein signaling 3)

2003-06-01  

Identity

HGNC
LOCATION
9q32
LOCUSID
ALIAS
C2PA,RGP3
FUSION GENES

Other Information

Locus ID:

NCBI: 5998
MIM: 602189
HGNC: 9999
Ensembl: ENSG00000138835

Variants:

dbSNP: 5998
ClinVar: 5998
TCGA: ENSG00000138835
COSMIC: RGS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138835ENST00000317613P49796
ENSG00000138835ENST00000342620H7BXY1
ENSG00000138835ENST00000343817P49796
ENSG00000138835ENST00000343817A0A024R841
ENSG00000138835ENST00000350696P49796
ENSG00000138835ENST00000374134P49796
ENSG00000138835ENST00000374134A0A024R831
ENSG00000138835ENST00000374136Q5VXC0
ENSG00000138835ENST00000374140P49796
ENSG00000138835ENST00000394646P49796
ENSG00000138835ENST00000462143P49796
ENSG00000138835ENST00000462143A0A024R831
ENSG00000138835ENST00000462403P49796
ENSG00000138835ENST00000462403A0A024R833
ENSG00000138835ENST00000467805C9J582
ENSG00000138835ENST00000471324C9J6G2
ENSG00000138835ENST00000496113H7C539
ENSG00000138835ENST00000613049P49796
ENSG00000138835ENST00000613049A0A024R833
ENSG00000138835ENST00000620489A0A087WUY2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
168210822007Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers.24
197789492010Genomic assessment of follicular marker genes as pregnancy predictors for human IVF.23
119854972002RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain.13
153836262004Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor.11
173009162007Regulator of G-protein signalling 3 redirects prototypical Gi-coupled receptors from Rac1 to RhoA activation.11
20347994201014-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3).11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
220278392011Structural basis for the 14-3-3 protein-dependent inhibition of the regulator of G protein signaling 3 (RGS3) function.11
228592932012Regulator of G-protein signaling 3 isoform 1 (PDZ-RGS3) enhances canonical Wnt signaling and promotes epithelial mesenchymal transition.8

Citation

Dessen P

RGS3 (regulator of G protein signaling 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42103/rgs3