Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RGS8 (regulator of G protein signaling 8)

Identity

Alias_namesregulator of G-protein signalling 8
Alias_symbol (synonym)MGC119067
MGC119068
MGC119069
Other alias-
HGNC (Hugo) RGS8
LocusID (NCBI) 85397
Atlas_Id 47429
Location 1q25.3  [Link to chromosome band 1q25]
Location_base_pair Starts at 182641814 and ends at 182672932 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADIPOR1 (1q32.1) / RGS8 (1q25.3)ADIPOR1 1q32.1 / RGS8 1q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q25;q32) ADIPOR1/RGS8


External links

Nomenclature
HGNC (Hugo)RGS8   16810
Cards
Entrez_Gene (NCBI)RGS8  85397  regulator of G protein signaling 8
Aliases
GeneCards (Weizmann)RGS8
Ensembl hg19 (Hinxton)ENSG00000135824 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135824 [Gene_View]  ENSG00000135824 [Sequence]  chr1:182641814-182672932 [Contig_View]  RGS8 [Vega]
ICGC DataPortalENSG00000135824
TCGA cBioPortalRGS8
AceView (NCBI)RGS8
Genatlas (Paris)RGS8
WikiGenes85397
SOURCE (Princeton)RGS8
Genetics Home Reference (NIH)RGS8
Genomic and cartography
GoldenPath hg38 (UCSC)RGS8  -     chr1:182641814-182672932 -  1q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RGS8  -     1q25.3   [Description]    (hg19-Feb_2009)
EnsemblRGS8 - 1q25.3 [CytoView hg19]  RGS8 - 1q25.3 [CytoView hg38]
Mapping of homologs : NCBIRGS8 [Mapview hg19]  RGS8 [Mapview hg38]
OMIM607189   
Gene and transcription
Genbank (Entrez)AF300649 AH010175 AI209102 AK057753 AK294660
RefSeq transcript (Entrez)NM_001102450 NM_033345
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RGS8
Cluster EST : UnigeneHs.458417 [ NCBI ]
CGAP (NCI)Hs.458417
Alternative Splicing GalleryENSG00000135824
Gene ExpressionRGS8 [ NCBI-GEO ]   RGS8 [ EBI - ARRAY_EXPRESS ]   RGS8 [ SEEK ]   RGS8 [ MEM ]
Gene Expression Viewer (FireBrowse)RGS8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85397
GTEX Portal (Tissue expression)RGS8
Human Protein AtlasENSG00000135824-RGS8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57771   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57771  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57771
Splice isoforms : SwissVarP57771
PhosPhoSitePlusP57771
Domaine pattern : Prosite (Expaxy)RGS (PS50132)   
Domains : Interpro (EBI)RGS    RGS_subdom1   
Domain families : Pfam (Sanger)RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  
Conserved Domain (NCBI)RGS8
DMDM Disease mutations85397
Blocks (Seattle)RGS8
PDB (SRS)2IHD    2ODE    5DO9   
PDB (PDBSum)2IHD    2ODE    5DO9   
PDB (IMB)2IHD    2ODE    5DO9   
PDB (RSDB)2IHD    2ODE    5DO9   
Structural Biology KnowledgeBase2IHD    2ODE    5DO9   
SCOP (Structural Classification of Proteins)2IHD    2ODE    5DO9   
CATH (Classification of proteins structures)2IHD    2ODE    5DO9   
SuperfamilyP57771
Human Protein Atlas [tissue]ENSG00000135824-RGS8 [tissue]
Peptide AtlasP57771
HPRD06221
IPIIPI00855716   IPI00100471   IPI00966740   
Protein Interaction databases
DIP (DOE-UCLA)P57771
IntAct (EBI)P57771
FunCoupENSG00000135824
BioGRIDRGS8
STRING (EMBL)RGS8
ZODIACRGS8
Ontologies - Pathways
QuickGOP57771
Ontology : AmiGOGTPase activator activity  protein binding  nucleus  cytoplasm  plasma membrane  G-protein coupled acetylcholine receptor signaling pathway  negative regulation of signal transduction  dendrite  extrinsic component of cytoplasmic side of plasma membrane  neuronal cell body membrane  perikaryon  positive regulation of GTPase activity  regulation of dopamine receptor signaling pathway  
Ontology : EGO-EBIGTPase activator activity  protein binding  nucleus  cytoplasm  plasma membrane  G-protein coupled acetylcholine receptor signaling pathway  negative regulation of signal transduction  dendrite  extrinsic component of cytoplasmic side of plasma membrane  neuronal cell body membrane  perikaryon  positive regulation of GTPase activity  regulation of dopamine receptor signaling pathway  
NDEx NetworkRGS8
Atlas of Cancer Signalling NetworkRGS8
Wikipedia pathwaysRGS8
Orthology - Evolution
OrthoDB85397
GeneTree (enSembl)ENSG00000135824
Phylogenetic Trees/Animal Genes : TreeFamRGS8
HOVERGENP57771
HOGENOMP57771
Homologs : HomoloGeneRGS8
Homology/Alignments : Family Browser (UCSC)RGS8
Gene fusions - Rearrangements
Fusion : MitelmanADIPOR1/RGS8 [1q32.1/1q25.3]  [t(1;1)(q25;q32)]  
Fusion PortalADIPOR1 1q32.1 RGS8 1q25.3 BRCA
Fusion : QuiverRGS8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRGS8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RGS8
dbVarRGS8
ClinVarRGS8
1000_GenomesRGS8 
Exome Variant ServerRGS8
ExAC (Exome Aggregation Consortium)ENSG00000135824
GNOMAD BrowserENSG00000135824
Genetic variants : HAPMAP85397
Genomic Variants (DGV)RGS8 [DGVbeta]
DECIPHERRGS8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRGS8 
Mutations
ICGC Data PortalRGS8 
TCGA Data PortalRGS8 
Broad Tumor PortalRGS8
OASIS PortalRGS8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRGS8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRGS8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RGS8
DgiDB (Drug Gene Interaction Database)RGS8
DoCM (Curated mutations)RGS8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RGS8 (select a term)
intoGenRGS8
Cancer3DRGS8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607189   
Orphanet
DisGeNETRGS8
MedgenRGS8
Genetic Testing Registry RGS8
NextProtP57771 [Medical]
TSGene85397
GENETestsRGS8
Target ValidationRGS8
Huge Navigator RGS8 [HugePedia]
snp3D : Map Gene to Disease85397
BioCentury BCIQRGS8
ClinGenRGS8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85397
Chemical/Pharm GKB GenePA34379
Clinical trialRGS8
Miscellaneous
canSAR (ICR)RGS8 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRGS8
EVEXRGS8
GoPubMedRGS8
iHOPRGS8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:47:04 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.