RGS9 (regulator of G protein signaling 9)

2014-11-01  

Identity

HGNC
LOCATION
17q24.1
LOCUSID
ALIAS
PERRS,RGS9L
FUSION GENES

Other Information

Locus ID:

NCBI: 8787
MIM: 604067
HGNC: 10004
Ensembl: ENSG00000108370

Variants:

dbSNP: 8787
ClinVar: 8787
TCGA: ENSG00000108370
COSMIC: RGS9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108370ENST00000262406O75916
ENSG00000108370ENST00000443584E9PD91
ENSG00000108370ENST00000449996O75916
ENSG00000108370ENST00000584234J3QL70
ENSG00000108370ENST00000635833A0A1B0GVU3

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
PhototransductionKEGGko04744
PhototransductionKEGGhsa04744
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Visual phototransductionREACTOMER-HSA-2187338
The phototransduction cascadeREACTOMER-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascadeREACTOMER-HSA-2514859
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
147020872004Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
204779432010RGS9-2 mediates specific inhibition of agonist-induced internalization of D2-dopamine receptors.27
238575812013Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells.26
203747172009Biology and functions of the RGS9 isoforms.15
215119472011Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors.15
199489752009Integrative predictive model of coronary artery calcification in atherosclerosis.13
198185062010Novel mutations and electrophysiologic findings in RGS9- and R9AP-associated retinal dysfunction (Bradyopsia).12
220060182011β-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation.10

Citation

Dessen P

RGS9 (regulator of G protein signaling 9)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72620/rgs9