RHBDD1 (rhomboid domain containing 1)

2014-09-01  

Identity

HGNC
LOCATION
2q36.3
LOCUSID
ALIAS
RHBDL4,RRP4
FUSION GENES

Other Information

Locus ID:

NCBI: 84236
MIM: 617515
HGNC: 23081
Ensembl: ENSG00000144468

Variants:

dbSNP: 84236
ClinVar: 84236
TCGA: ENSG00000144468
COSMIC: RHBDD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144468ENST00000341329Q8TEB9
ENSG00000144468ENST00000341329A0A024R455
ENSG00000144468ENST00000392062Q8TEB9
ENSG00000144468ENST00000392062A0A024R455
ENSG00000144468ENST00000409053B9A054
ENSG00000144468ENST00000423616C9K011
ENSG00000144468ENST00000424132C9J1R4
ENSG00000144468ENST00000436481C9JAS2
ENSG00000144468ENST00000437454C9J4C7
ENSG00000144468ENST00000448992C9JQK8

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
189536872008A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis.16
294263642018RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1.13
226240352012Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.9
236693652013Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP-1 activity and its downstream target Bcl-3.9
275630672016Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4.7
312436442019MicroRNA-138-5p inhibits cell migration, invasion and EMT in breast cancer by directly targeting RHBDD1.5
302867652018Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels.4
235347822013Lentivirus-mediated silencing of rhomboid domain containing 1 suppresses tumor growth and induces apoptosis in hepatoma HepG2 cells.3
238834332014Lentiviral vector mediated delivery of RHBDD1 shRNA down regulated the proliferation of human glioblastoma cells.3
301435352018Membrane cholesterol as regulator of human rhomboid protease RHBDL4.3

Citation

Dessen P

RHBDD1 (rhomboid domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54884/rhbdd1