RHBG (Rh family B glycoprotein)

2014-11-01  

Identity

HGNC
RHBG
LOCATION
1q22
LOCUSID
57127
ALIAS
SLC42A2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57127
MIM: 607079
HGNC: 14572
Ensembl: ENSG00000132677

Variants:

dbSNP: 57127
ClinVar: 57127
TCGA: ENSG00000132677
COSMIC: RHBG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132677ENST00000451864F6Q468
ENSG00000132677ENST00000537040Q9H310
ENSG00000132677ENST00000612897A0A087WTF7
ENSG00000132677ENST00000613460F6Q468
ENSG00000132677ENST00000620376A0A087WUR4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Rhesus glycoproteins mediate ammonium transport.REACTOMER-HSA-444411

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
152843422004Electroneutral ammonium transport by basolateral rhesus B glycoprotein.43
159297232005Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells.30
246477132014Ammonia transport in the kidney by Rhesus glycoproteins.28
194297722009Expression of the gas-transporting proteins, Rh B glycoprotein and Rh C glycoprotein, in the murine lung.21
156110822005The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.15
233241762013Expression of the ammonia transporter family member, Rh B Glycoprotein, in the human kidney.14
193571822009RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels.13
240779892013Relative CO₂/NH₃ permeabilities of human RhAG, RhBG and RhCG.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

RHBG (Rh family B glycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72627/rhbg