RHCG (Rh family C glycoprotein)

2018-12-01  

Identity

HGNC
RHCG
LOCATION
15q26.1
LOCUSID
51458
ALIAS
C15orf6,PDRC2,RHGK,SLC42A3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51458
MIM: 605381
HGNC: 18140
Ensembl: ENSG00000140519

Variants:

dbSNP: 51458
ClinVar: 51458
TCGA: ENSG00000140519
COSMIC: RHCG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140519ENST00000268122Q9UBD6
ENSG00000140519ENST00000558030H0YKQ3
ENSG00000140519ENST00000558184H0YMS1
ENSG00000140519ENST00000558360H0YM79
ENSG00000140519ENST00000560081H0YMF8
ENSG00000140519ENST00000649642A0A3B3IT41

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Rhesus glycoproteins mediate ammonium transport.REACTOMER-HSA-444411

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
204579422010Function of human Rh based on structure of RhCG at 2.1 A.63
159297232005Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells.30
246477132014Ammonia transport in the kidney by Rhesus glycoproteins.28
194297722009Expression of the gas-transporting proteins, Rh B glycoprotein and Rh C glycoprotein, in the murine lung.21
201266672010Functional reconstitution into liposomes of purified human RhCG ammonia channel.18
183671542008Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3.13
193571822009RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels.13
240779892013Relative CO₂/NH₃ permeabilities of human RhAG, RhBG and RhCG.12
165647242006The challenge of understanding ammonium homeostasis and the role of the Rh glycoproteins.11

Citation

Dessen P

RHCG (Rh family C glycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57771/rhcg