Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RHEB (Ras homolog enriched in brain)

Identity

Alias_namesRHEB2
Ras homolog enriched in brain 2
Other alias
HGNC (Hugo) RHEB
LocusID (NCBI) 6009
Atlas_Id 42104
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 151163098 and ends at 151217010 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EPS8 (12p12.3) / RHEB (7q36.1)LOC100130557 () / RHEB (7q36.1)RHEB (7q36.1) / PRKAG2 (7q36.1)
UFC1 (1q23.3) / RHEB (7q36.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lymphangioleiomyomatosis


External links

Nomenclature
HGNC (Hugo)RHEB   10011
Cards
Entrez_Gene (NCBI)RHEB  6009  Ras homolog enriched in brain
AliasesRHEB2
GeneCards (Weizmann)RHEB
Ensembl hg19 (Hinxton)ENSG00000106615 [Gene_View]  chr7:151163098-151217010 [Contig_View]  RHEB [Vega]
Ensembl hg38 (Hinxton)ENSG00000106615 [Gene_View]  chr7:151163098-151217010 [Contig_View]  RHEB [Vega]
ICGC DataPortalENSG00000106615
TCGA cBioPortalRHEB
AceView (NCBI)RHEB
Genatlas (Paris)RHEB
WikiGenes6009
SOURCE (Princeton)RHEB
Genetics Home Reference (NIH)RHEB
Genomic and cartography
GoldenPath hg19 (UCSC)RHEB  -     chr7:151163098-151217010 -  7q36.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RHEB  -     7q36.1   [Description]    (hg38-Dec_2013)
EnsemblRHEB - 7q36.1 [CytoView hg19]  RHEB - 7q36.1 [CytoView hg38]
Mapping of homologs : NCBIRHEB [Mapview hg19]  RHEB [Mapview hg38]
OMIM601293   
Gene and transcription
Genbank (Entrez)AF148645 AF493921 AK125446 AK289370 BC016155
RefSeq transcript (Entrez)NM_005614
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929333
Consensus coding sequences : CCDS (NCBI)RHEB
Cluster EST : UnigeneHs.647068 [ NCBI ]
CGAP (NCI)Hs.647068
Alternative Splicing GalleryENSG00000106615
Gene ExpressionRHEB [ NCBI-GEO ]   RHEB [ EBI - ARRAY_EXPRESS ]   RHEB [ SEEK ]   RHEB [ MEM ]
Gene Expression Viewer (FireBrowse)RHEB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6009
GTEX Portal (Tissue expression)RHEB
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15382   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15382  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15382
Splice isoforms : SwissVarQ15382
PhosPhoSitePlusQ15382
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAS (SM00173)  
Conserved Domain (NCBI)RHEB
DMDM Disease mutations6009
Blocks (Seattle)RHEB
PDB (SRS)1XTQ    1XTR    1XTS    3SEA    3T5G   
PDB (PDBSum)1XTQ    1XTR    1XTS    3SEA    3T5G   
PDB (IMB)1XTQ    1XTR    1XTS    3SEA    3T5G   
PDB (RSDB)1XTQ    1XTR    1XTS    3SEA    3T5G   
Structural Biology KnowledgeBase1XTQ    1XTR    1XTS    3SEA    3T5G   
SCOP (Structural Classification of Proteins)1XTQ    1XTR    1XTS    3SEA    3T5G   
CATH (Classification of proteins structures)1XTQ    1XTR    1XTS    3SEA    3T5G   
SuperfamilyQ15382
Human Protein AtlasENSG00000106615
Peptide AtlasQ15382
HPRD03188
IPIIPI00016669   IPI00947020   IPI00945356   IPI00945139   
Protein Interaction databases
DIP (DOE-UCLA)Q15382
IntAct (EBI)Q15382
FunCoupENSG00000106615
BioGRIDRHEB
STRING (EMBL)RHEB
ZODIACRHEB
Ontologies - Pathways
QuickGOQ15382
Ontology : AmiGOGolgi membrane  GTPase activity  protein binding  GTP binding  spliceosomal complex  lysosomal membrane  endoplasmic reticulum membrane  cytosol  cell cycle arrest  signal transduction  small GTPase mediated signal transduction  protein transport  membrane  macroautophagy  protein kinase binding  positive regulation of TOR signaling  metal ion binding  positive regulation of oligodendrocyte differentiation  extracellular exosome  regulation of type B pancreatic cell development  
Ontology : EGO-EBIGolgi membrane  GTPase activity  protein binding  GTP binding  spliceosomal complex  lysosomal membrane  endoplasmic reticulum membrane  cytosol  cell cycle arrest  signal transduction  small GTPase mediated signal transduction  protein transport  membrane  macroautophagy  protein kinase binding  positive regulation of TOR signaling  metal ion binding  positive regulation of oligodendrocyte differentiation  extracellular exosome  regulation of type B pancreatic cell development  
Pathways : BIOCARTAmTOR Signaling Pathway [Genes]   
Pathways : KEGGmTOR signaling pathway    PI3K-Akt signaling pathway    Insulin signaling pathway    Thyroid hormone signaling pathway   
NDEx NetworkRHEB
Atlas of Cancer Signalling NetworkRHEB
Wikipedia pathwaysRHEB
Orthology - Evolution
OrthoDB6009
GeneTree (enSembl)ENSG00000106615
Phylogenetic Trees/Animal Genes : TreeFamRHEB
HOVERGENQ15382
HOGENOMQ15382
Homologs : HomoloGeneRHEB
Homology/Alignments : Family Browser (UCSC)RHEB
Gene fusions - Rearrangements
Fusion : MitelmanRHEB/PRKAG2 [7q36.1/7q36.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRHEB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RHEB
dbVarRHEB
ClinVarRHEB
1000_GenomesRHEB 
Exome Variant ServerRHEB
ExAC (Exome Aggregation Consortium)RHEB (select the gene name)
Genetic variants : HAPMAP6009
Genomic Variants (DGV)RHEB [DGVbeta]
DECIPHER (Syndromes)7:151163098-151217010  ENSG00000106615
CONAN: Copy Number AnalysisRHEB 
Mutations
ICGC Data PortalRHEB 
TCGA Data PortalRHEB 
Broad Tumor PortalRHEB
OASIS PortalRHEB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRHEB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRHEB
intOGen PortalRHEB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RHEB
DgiDB (Drug Gene Interaction Database)RHEB
DoCM (Curated mutations)RHEB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RHEB (select a term)
intoGenRHEB
Cancer3DRHEB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601293   
Orphanet
MedgenRHEB
Genetic Testing Registry RHEB
NextProtQ15382 [Medical]
TSGene6009
GENETestsRHEB
Huge Navigator RHEB [HugePedia]
snp3D : Map Gene to Disease6009
BioCentury BCIQRHEB
ClinGenRHEB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6009
Chemical/Pharm GKB GenePA34389
Clinical trialRHEB
Miscellaneous
canSAR (ICR)RHEB (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRHEB
EVEXRHEB
GoPubMedRHEB
iHOPRHEB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:25:01 CET 2017

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