Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RHEB (Ras homolog, mTORC1 binding)

Identity

Alias (NCBI)RHEB2
HGNC (Hugo) RHEB
HGNC Previous nameRHEB2
HGNC Previous nameRas homolog enriched in brain 2
 Ras homolog enriched in brain
LocusID (NCBI) 6009
Atlas_Id 42104
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 151466012 and ends at 151519895 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EPS8 (12p12.3) / RHEB (7q36.1)LOC100130557 () / RHEB (7q36.1)RHEB (7q36.1) / PRKAG2 (7q36.1)
UFC1 (1q23.3) / RHEB (7q36.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RHEB   10011
Cards
Entrez_Gene (NCBI)RHEB    Ras homolog, mTORC1 binding
AliasesRHEB2
GeneCards (Weizmann)RHEB
Ensembl hg19 (Hinxton)ENSG00000106615 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106615 [Gene_View]  ENSG00000106615 [Sequence]  chr7:151466012-151519895 [Contig_View]  RHEB [Vega]
ICGC DataPortalENSG00000106615
TCGA cBioPortalRHEB
AceView (NCBI)RHEB
Genatlas (Paris)RHEB
SOURCE (Princeton)RHEB
Genetics Home Reference (NIH)RHEB
Genomic and cartography
GoldenPath hg38 (UCSC)RHEB  -     chr7:151466012-151519895 -  7q36.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RHEB  -     7q36.1   [Description]    (hg19-Feb_2009)
GoldenPathRHEB - 7q36.1 [CytoView hg19]  RHEB - 7q36.1 [CytoView hg38]
ImmunoBaseENSG00000106615
Genome Data Viewer NCBIRHEB [Mapview hg19]  
OMIM601293   
Gene and transcription
Genbank (Entrez)AF148645 AF493921 AK125446 AK289370 BC016155
RefSeq transcript (Entrez)NM_005614
Consensus coding sequences : CCDS (NCBI)RHEB
Gene ExpressionRHEB [ NCBI-GEO ]   RHEB [ EBI - ARRAY_EXPRESS ]   RHEB [ SEEK ]   RHEB [ MEM ]
Gene Expression Viewer (FireBrowse)RHEB [ Firebrowse - Broad ]
GenevisibleExpression of RHEB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6009
GTEX Portal (Tissue expression)RHEB
Human Protein AtlasENSG00000106615-RHEB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15382   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15382  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15382
PhosPhoSitePlusQ15382
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    RHEB    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras-type   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RHEB
PDB (RSDB)1XTQ    1XTR    1XTS    3SEA    3T5G    5YXH    6BCU    6BSX    6BT0    7BTA    7BTC    7BTD   
PDB Europe1XTQ    1XTR    1XTS    3SEA    3T5G    5YXH    6BCU    6BSX    6BT0    7BTA    7BTC    7BTD   
PDB (PDBSum)1XTQ    1XTR    1XTS    3SEA    3T5G    5YXH    6BCU    6BSX    6BT0    7BTA    7BTC    7BTD   
PDB (IMB)1XTQ    1XTR    1XTS    3SEA    3T5G    5YXH    6BCU    6BSX    6BT0    7BTA    7BTC    7BTD   
Structural Biology KnowledgeBase1XTQ    1XTR    1XTS    3SEA    3T5G    5YXH    6BCU    6BSX    6BT0    7BTA    7BTC    7BTD   
SCOP (Structural Classification of Proteins)1XTQ    1XTR    1XTS    3SEA    3T5G    5YXH    6BCU    6BSX    6BT0    7BTA    7BTC    7BTD   
CATH (Classification of proteins structures)1XTQ    1XTR    1XTS    3SEA    3T5G    5YXH    6BCU    6BSX    6BT0    7BTA    7BTC    7BTD   
SuperfamilyQ15382
AlphaFold pdb e-kbQ15382   
Human Protein Atlas [tissue]ENSG00000106615-RHEB [tissue]
HPRD03188
Protein Interaction databases
DIP (DOE-UCLA)Q15382
IntAct (EBI)Q15382
BioGRIDRHEB
STRING (EMBL)RHEB
ZODIACRHEB
Ontologies - Pathways
QuickGOQ15382
Ontology : AmiGOGolgi membrane  magnesium ion binding  GTPase activity  protein binding  GTP binding  GTP binding  GTP binding  spliceosomal complex  lysosomal membrane  endoplasmic reticulum membrane  cytosol  plasma membrane  signal transduction  small GTPase mediated signal transduction  postsynaptic density  postsynaptic density  membrane  regulation of macroautophagy  GDP binding  GDP binding  protein kinase binding  positive regulation of TOR signaling  cellular response to amino acid starvation  positive regulation of oligodendrocyte differentiation  extracellular exosome  negative regulation of cold-induced thermogenesis  regulation of type B pancreatic cell development  
Ontology : EGO-EBIGolgi membrane  magnesium ion binding  GTPase activity  protein binding  GTP binding  GTP binding  GTP binding  spliceosomal complex  lysosomal membrane  endoplasmic reticulum membrane  cytosol  plasma membrane  signal transduction  small GTPase mediated signal transduction  postsynaptic density  postsynaptic density  membrane  regulation of macroautophagy  GDP binding  GDP binding  protein kinase binding  positive regulation of TOR signaling  cellular response to amino acid starvation  positive regulation of oligodendrocyte differentiation  extracellular exosome  negative regulation of cold-induced thermogenesis  regulation of type B pancreatic cell development  
Pathways : BIOCARTAmTOR Signaling Pathway [Genes]   
Pathways : KEGGmTOR signaling pathway    PI3K-Akt signaling pathway    Insulin signaling pathway    Thyroid hormone signaling pathway   
NDEx NetworkRHEB
Atlas of Cancer Signalling NetworkRHEB
Wikipedia pathwaysRHEB
Orthology - Evolution
OrthoDB6009
GeneTree (enSembl)ENSG00000106615
Phylogenetic Trees/Animal Genes : TreeFamRHEB
Homologs : HomoloGeneRHEB
Homology/Alignments : Family Browser (UCSC)RHEB
Gene fusions - Rearrangements
Fusion : MitelmanRHEB/PRKAG2 [7q36.1/7q36.1]  
Fusion : QuiverRHEB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRHEB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RHEB
dbVarRHEB
ClinVarRHEB
MonarchRHEB
1000_GenomesRHEB 
Exome Variant ServerRHEB
GNOMAD BrowserENSG00000106615
Varsome BrowserRHEB
ACMGRHEB variants
VarityQ15382
Genomic Variants (DGV)RHEB [DGVbeta]
DECIPHERRHEB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRHEB 
Mutations
ICGC Data PortalRHEB 
TCGA Data PortalRHEB 
Broad Tumor PortalRHEB
OASIS PortalRHEB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRHEB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRHEB
Mutations and Diseases : HGMDRHEB
intOGen PortalRHEB
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRHEB
DgiDB (Drug Gene Interaction Database)RHEB
DoCM (Curated mutations)RHEB
CIViC (Clinical Interpretations of Variants in Cancer)RHEB
Cancer3DRHEB
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601293   
Orphanet
DisGeNETRHEB
MedgenRHEB
Genetic Testing Registry RHEB
NextProtQ15382 [Medical]
GENETestsRHEB
Target ValidationRHEB
Huge Navigator RHEB [HugePedia]
ClinGenRHEB
Clinical trials, drugs, therapy
MyCancerGenomeRHEB
Protein Interactions : CTDRHEB
Pharm GKB GenePA34389
PharosQ15382
Clinical trialRHEB
Miscellaneous
canSAR (ICR)RHEB
HarmonizomeRHEB
DataMed IndexRHEB
Probes
Litterature
PubMed141 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRHEB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:28:54 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.