RHNO1 (RAD9-HUS1-RAD1 interacting nuclear orphan 1)

2012-09-01  

Identity

HGNC
LOCATION
12p13.33
LOCUSID
ALIAS
C12orf32,HKMT1188,RHINO

Other Information

Locus ID:

NCBI: 83695
MIM: 614085
HGNC: 28206
Ensembl: ENSG00000171792

Variants:

dbSNP: 83695
ClinVar: 83695
TCGA: ENSG00000171792
COSMIC: RHNO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171792ENST00000366285F5H580
ENSG00000171792ENST00000461997Q9BSD3
ENSG00000171792ENST00000489288Q9BSD3
ENSG00000171792ENST00000535978F5H795
ENSG00000171792ENST00000538636F5H7S2
ENSG00000171792ENST00000538700F5H0U1
ENSG00000171792ENST00000618250Q9BSD3

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

References

Pubmed IDYearTitleCitations
216596032011A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.92
256025202015RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.14
208117082010Involvement of C12orf32 overexpression in breast carcinogenesis.5
245627722014Evaluation of the RHINO gene for breast cancer predisposition in Finnish breast cancer families.1

Citation

Dessen P

RHNO1 (RAD9-HUS1-RAD1 interacting nuclear orphan 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52867/rhno1