Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RHOG (ras homolog family member G)

Identity

Alias (NCBI)ARHG
HGNC (Hugo) RHOG
HGNC Alias symbRhoG
MGC125835
MGC125836
HGNC Previous nameARHG
HGNC Previous nameras homolog gene family, member G (rho G)
LocusID (NCBI) 391
Atlas_Id 42111
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 3826978 and ends at 3840959 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUP98 (11p15.4) / RHOG (11p15.4)OSBPL5 (11p15.4) / RHOG (11p15.4)PRLR (5p13.2) / RHOG (11p15.4)
TTTY14 (Yq11.222) / RHOG (11p15.4)NUP98 11p15.4 / RHOG 11p15.4OSBPL5 11p15.4 / RHOG 11p15.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  NUP98/RHOG (11p15)
OSBPL5/RHOG (11p15)

External links

Nomenclature
HGNC (Hugo)RHOG   672
Cards
Entrez_Gene (NCBI)RHOG  391  ras homolog family member G
AliasesARHG
GeneCards (Weizmann)RHOG
Ensembl hg19 (Hinxton)ENSG00000177105 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177105 [Gene_View]  ENSG00000177105 [Sequence]  chr11:3826978-3840959 [Contig_View]  RHOG [Vega]
ICGC DataPortalENSG00000177105
TCGA cBioPortalRHOG
AceView (NCBI)RHOG
Genatlas (Paris)RHOG
WikiGenes391
SOURCE (Princeton)RHOG
Genetics Home Reference (NIH)RHOG
Genomic and cartography
GoldenPath hg38 (UCSC)RHOG  -     chr11:3826978-3840959 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RHOG  -     11p15.4   [Description]    (hg19-Feb_2009)
GoldenPathRHOG - 11p15.4 [CytoView hg19]  RHOG - 11p15.4 [CytoView hg38]
ImmunoBaseENSG00000177105
genome Data Viewer NCBIRHOG [Mapview hg19]  
OMIM179505   
Gene and transcription
Genbank (Entrez)AA424888 AF498974 AY563952 BC104177 BC104178
RefSeq transcript (Entrez)NM_001665
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RHOG
Alternative Splicing GalleryENSG00000177105
Gene ExpressionRHOG [ NCBI-GEO ]   RHOG [ EBI - ARRAY_EXPRESS ]   RHOG [ SEEK ]   RHOG [ MEM ]
Gene Expression Viewer (FireBrowse)RHOG [ Firebrowse - Broad ]
GenevisibleExpression of RHOG in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)391
GTEX Portal (Tissue expression)RHOG
Human Protein AtlasENSG00000177105-RHOG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP84095   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP84095  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP84095
Splice isoforms : SwissVarP84095
PhosPhoSitePlusP84095
Domaine pattern : Prosite (Expaxy)RHO (PS51420)   
Domains : Interpro (EBI)P-loop_NTPase    RhoG    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Rho   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RHOG
DMDM Disease mutations391
Blocks (Seattle)RHOG
SuperfamilyP84095
Human Protein Atlas [tissue]ENSG00000177105-RHOG [tissue]
Peptide AtlasP84095
HPRD01537
IPIIPI00017342   
Protein Interaction databases
DIP (DOE-UCLA)P84095
IntAct (EBI)P84095
FunCoupENSG00000177105
BioGRIDRHOG
STRING (EMBL)RHOG
ZODIACRHOG
Ontologies - Pathways
QuickGOP84095
Ontology : AmiGOGTPase activity  GTPase activity  protein binding  GTP binding  cytoplasm  endoplasmic reticulum membrane  cytosol  cytoskeleton  plasma membrane  plasma membrane  focal adhesion  cell cortex  actin filament organization  Rho protein signal transduction  motor neuron axon guidance  positive regulation of cell proliferation  regulation of cell shape  Rac protein signal transduction  Rac protein signal transduction  protein kinase binding  cell projection assembly  actin cytoskeleton organization  actin cytoskeleton organization  secretory granule membrane  cortical cytoskeleton organization  cytoplasmic vesicle  regulation of actin cytoskeleton organization  cell projection  intracellular membrane-bounded organelle  neutrophil degranulation  engulfment of apoptotic cell  positive regulation of transcription, DNA-templated  regulation of small GTPase mediated signal transduction  positive regulation of protein kinase B signaling  cell chemotaxis  extracellular exosome  activation of GTPase activity  regulation of ruffle assembly  regulation of neutrophil migration  positive regulation of protein localization to plasma membrane  
Ontology : EGO-EBIGTPase activity  GTPase activity  protein binding  GTP binding  cytoplasm  endoplasmic reticulum membrane  cytosol  cytoskeleton  plasma membrane  plasma membrane  focal adhesion  cell cortex  actin filament organization  Rho protein signal transduction  motor neuron axon guidance  positive regulation of cell proliferation  regulation of cell shape  Rac protein signal transduction  Rac protein signal transduction  protein kinase binding  cell projection assembly  actin cytoskeleton organization  actin cytoskeleton organization  secretory granule membrane  cortical cytoskeleton organization  cytoplasmic vesicle  regulation of actin cytoskeleton organization  cell projection  intracellular membrane-bounded organelle  neutrophil degranulation  engulfment of apoptotic cell  positive regulation of transcription, DNA-templated  regulation of small GTPase mediated signal transduction  positive regulation of protein kinase B signaling  cell chemotaxis  extracellular exosome  activation of GTPase activity  regulation of ruffle assembly  regulation of neutrophil migration  positive regulation of protein localization to plasma membrane  
Pathways : KEGGBacterial invasion of epithelial cells    Shigellosis    Salmonella infection   
NDEx NetworkRHOG
Atlas of Cancer Signalling NetworkRHOG
Wikipedia pathwaysRHOG
Orthology - Evolution
OrthoDB391
GeneTree (enSembl)ENSG00000177105
Phylogenetic Trees/Animal Genes : TreeFamRHOG
HOGENOMP84095
Homologs : HomoloGeneRHOG
Homology/Alignments : Family Browser (UCSC)RHOG
Gene fusions - Rearrangements
Fusion : MitelmanNUP98/RHOG [11p15.4/11p15.4]  
Fusion : MitelmanOSBPL5/RHOG [11p15.4/11p15.4]  
Fusion PortalNUP98 11p15.4 RHOG 11p15.4 BRCA
Fusion PortalOSBPL5 11p15.4 RHOG 11p15.4 BRCA
Fusion : QuiverRHOG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRHOG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RHOG
dbVarRHOG
ClinVarRHOG
MonarchRHOG
1000_GenomesRHOG 
Exome Variant ServerRHOG
GNOMAD BrowserENSG00000177105
Varsome BrowserRHOG
Genetic variants : HAPMAP391
Genomic Variants (DGV)RHOG [DGVbeta]
DECIPHERRHOG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRHOG 
Mutations
ICGC Data PortalRHOG 
TCGA Data PortalRHOG 
Broad Tumor PortalRHOG
OASIS PortalRHOG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRHOG  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRHOG
Mutations and Diseases : HGMDRHOG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RHOG
DgiDB (Drug Gene Interaction Database)RHOG
DoCM (Curated mutations)RHOG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RHOG (select a term)
intoGenRHOG
Cancer3DRHOG(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179505   
Orphanet
DisGeNETRHOG
MedgenRHOG
Genetic Testing Registry RHOG
NextProtP84095 [Medical]
TSGene391
GENETestsRHOG
Target ValidationRHOG
Huge Navigator RHOG [HugePedia]
snp3D : Map Gene to Disease391
BioCentury BCIQRHOG
ClinGenRHOG
Clinical trials, drugs, therapy
Protein Interactions : CTD391
Pharm GKB GenePA24955
Clinical trialRHOG
Miscellaneous
canSAR (ICR)RHOG (select the gene name)
HarmonizomeRHOG
DataMed IndexRHOG
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRHOG
EVEXRHOG
GoPubMedRHOG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:30:16 CEST 2020
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