RHOJ (ras homolog family member J)

2004-04-01  

Identity

HGNC
LOCATION
14q23.2
LOCUSID
ALIAS
ARHJ,RASL7B,TC10B,TCL
FUSION GENES

Other Information

Locus ID:

NCBI: 57381
MIM: 607653
HGNC: 688
Ensembl: ENSG00000126785

Variants:

dbSNP: 57381
ClinVar: 57381
TCGA: ENSG00000126785
COSMIC: RHOJ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126785ENST00000316754Q9H4E5
ENSG00000126785ENST00000316754A0A024R692
ENSG00000126785ENST00000555125G3V476
ENSG00000126785ENST00000557447G3V4H1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
244342132014Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption.31
216284092011RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG.27
211484272011RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers.26
229713442012RhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damage.23
129604282003The GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathway.20
249288942014RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly.19
230292802012Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.18
232538912013RhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics.14
262995182015The Formin FMNL3 Controls Early Apical Specification in Endothelial Cells by Regulating the Polarized Trafficking of Podocalyxin.8

Citation

Dessen P

RHOJ (ras homolog family member J)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/42112/rhoj