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RHOT1 (ras homolog family member T1)

Identity

Alias_namesARHT1
ras homolog gene family
Alias_symbol (synonym)MIRO-1
FLJ11040
Other aliasMIRO1
HGNC (Hugo) RHOT1
LocusID (NCBI) 55288
Atlas_Id 42114
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 32142454 and ends at 32225771 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PCMTD1 (8q11.23) / RHOT1 (17q11.2)RHOT1 (17q11.2) / ANKRD20A5P (18p11.21)RHOT1 (17q11.2) / CA10 (17q21.33)
RHOT1 (17q11.2) / FGFR1 (8p11.23)RHOT1 (17q11.2) / LRRC37B (17q11.2)RHOT1 (17q11.2) / RHOT1 (17q11.2)
RHOT1 (17q11.2) / SNHG1 (11q12.3)TNKS (8p23.1) / RHOT1 (17q11.2)PCMTD1 8q11.23 / RHOT1 17q11.2
RHOT1 17q11.2 / CA10 17q21.33RHOT1 17q11.2 / FGFR1 8p11.23RHOT1 17q11.2 / LRRC37B 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RHOT1   21168
Cards
Entrez_Gene (NCBI)RHOT1  55288  ras homolog family member T1
AliasesARHT1; MIRO-1; MIRO1
GeneCards (Weizmann)RHOT1
Ensembl hg19 (Hinxton)ENSG00000126858 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126858 [Gene_View]  chr17:32142454-32225771 [Contig_View]  RHOT1 [Vega]
ICGC DataPortalENSG00000126858
TCGA cBioPortalRHOT1
AceView (NCBI)RHOT1
Genatlas (Paris)RHOT1
WikiGenes55288
SOURCE (Princeton)RHOT1
Genetics Home Reference (NIH)RHOT1
Genomic and cartography
GoldenPath hg38 (UCSC)RHOT1  -     chr17:32142454-32225771 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RHOT1  -     17q11.2   [Description]    (hg19-Feb_2009)
EnsemblRHOT1 - 17q11.2 [CytoView hg19]  RHOT1 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBIRHOT1 [Mapview hg19]  RHOT1 [Mapview hg38]
OMIM613888   
Gene and transcription
Genbank (Entrez)AA772711 AJ496730 AJ517412 AK001902 AK022695
RefSeq transcript (Entrez)NM_001033566 NM_001033567 NM_001033568 NM_001288754 NM_001288755 NM_001288758 NM_018307
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RHOT1
Cluster EST : UnigeneHs.655325 [ NCBI ]
CGAP (NCI)Hs.655325
Alternative Splicing GalleryENSG00000126858
Gene ExpressionRHOT1 [ NCBI-GEO ]   RHOT1 [ EBI - ARRAY_EXPRESS ]   RHOT1 [ SEEK ]   RHOT1 [ MEM ]
Gene Expression Viewer (FireBrowse)RHOT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55288
GTEX Portal (Tissue expression)RHOT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IXI2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IXI2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IXI2
Splice isoforms : SwissVarQ8IXI2
Catalytic activity : Enzyme3.6.5.- [ Enzyme-Expasy ]   3.6.5.-3.6.5.- [ IntEnz-EBI ]   3.6.5.- [ BRENDA ]   3.6.5.- [ KEGG ]   
PhosPhoSitePlusQ8IXI2
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    MIRO (PS51423)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_assoc_1    EF_hand_assoc_2    EF_hand_dom    MIRO_dom    Mt_Rho_GTPase    P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)EF_assoc_1 (PF08355)    EF_assoc_2 (PF08356)    Ras (PF00071)   
Domain families : Pfam (NCBI)pfam08355    pfam08356    pfam00071   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)RHOT1
DMDM Disease mutations55288
Blocks (Seattle)RHOT1
PDB (SRS)5KSO    5KSP    5KSY    5KSZ    5KTY    5KU1   
PDB (PDBSum)5KSO    5KSP    5KSY    5KSZ    5KTY    5KU1   
PDB (IMB)5KSO    5KSP    5KSY    5KSZ    5KTY    5KU1   
PDB (RSDB)5KSO    5KSP    5KSY    5KSZ    5KTY    5KU1   
Structural Biology KnowledgeBase5KSO    5KSP    5KSY    5KSZ    5KTY    5KU1   
SCOP (Structural Classification of Proteins)5KSO    5KSP    5KSY    5KSZ    5KTY    5KU1   
CATH (Classification of proteins structures)5KSO    5KSP    5KSY    5KSZ    5KTY    5KU1   
SuperfamilyQ8IXI2
Human Protein AtlasENSG00000126858
Peptide AtlasQ8IXI2
HPRD15247
IPIIPI00432452   IPI00759714   IPI00217536   IPI00759775   IPI00759627   IPI00651681   
Protein Interaction databases
DIP (DOE-UCLA)Q8IXI2
IntAct (EBI)Q8IXI2
FunCoupENSG00000126858
BioGRIDRHOT1
STRING (EMBL)RHOT1
ZODIACRHOT1
Ontologies - Pathways
QuickGOQ8IXI2
Ontology : AmiGOmolecular_function  GTPase activity  calcium ion binding  protein binding  GTP binding  mitochondrion  mitochondrial outer membrane  cytosol  plasma membrane  small GTPase mediated signal transduction  membrane  protein deubiquitination  cellular homeostasis  integral component of mitochondrial outer membrane  mitochondrion transport along microtubule  regulation of small GTPase mediated signal transduction  mitochondrial outer membrane permeabilization  
Ontology : EGO-EBImolecular_function  GTPase activity  calcium ion binding  protein binding  GTP binding  mitochondrion  mitochondrial outer membrane  cytosol  plasma membrane  small GTPase mediated signal transduction  membrane  protein deubiquitination  cellular homeostasis  integral component of mitochondrial outer membrane  mitochondrion transport along microtubule  regulation of small GTPase mediated signal transduction  mitochondrial outer membrane permeabilization  
NDEx NetworkRHOT1
Atlas of Cancer Signalling NetworkRHOT1
Wikipedia pathwaysRHOT1
Orthology - Evolution
OrthoDB55288
GeneTree (enSembl)ENSG00000126858
Phylogenetic Trees/Animal Genes : TreeFamRHOT1
HOVERGENQ8IXI2
HOGENOMQ8IXI2
Homologs : HomoloGeneRHOT1
Homology/Alignments : Family Browser (UCSC)RHOT1
Gene fusions - Rearrangements
Fusion : MitelmanPCMTD1/RHOT1 [8q11.23/17q11.2]  [t(8;17)(q11;q11)]  
Fusion : MitelmanRHOT1/CA10 [17q11.2/17q21.33]  [t(17;17)(q11;q22)]  
Fusion : MitelmanRHOT1/FGFR1 [17q11.2/8p11.23]  [t(8;17)(p11;q11)]  
Fusion : MitelmanRHOT1/LRRC37B [17q11.2/17q11.2]  [t(17;17)(q11;q11)]  
Fusion: TCGAPCMTD1 8q11.23 RHOT1 17q11.2 BLCA
Fusion: TCGARHOT1 17q11.2 CA10 17q21.33 BRCA
Fusion: TCGARHOT1 17q11.2 FGFR1 8p11.23 BRCA
Fusion: TCGARHOT1 17q11.2 LRRC37B 17q11.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRHOT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RHOT1
dbVarRHOT1
ClinVarRHOT1
1000_GenomesRHOT1 
Exome Variant ServerRHOT1
ExAC (Exome Aggregation Consortium)RHOT1 (select the gene name)
Genetic variants : HAPMAP55288
Genomic Variants (DGV)RHOT1 [DGVbeta]
DECIPHERRHOT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRHOT1 
Mutations
ICGC Data PortalRHOT1 
TCGA Data PortalRHOT1 
Broad Tumor PortalRHOT1
OASIS PortalRHOT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRHOT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRHOT1
intOGen PortalRHOT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch RHOT1
DgiDB (Drug Gene Interaction Database)RHOT1
DoCM (Curated mutations)RHOT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RHOT1 (select a term)
intoGenRHOT1
Cancer3DRHOT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613888   
Orphanet
MedgenRHOT1
Genetic Testing Registry RHOT1
NextProtQ8IXI2 [Medical]
TSGene55288
GENETestsRHOT1
Target ValidationRHOT1
Huge Navigator RHOT1 [HugePedia]
snp3D : Map Gene to Disease55288
BioCentury BCIQRHOT1
ClinGenRHOT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55288
Chemical/Pharm GKB GenePA134906318
Clinical trialRHOT1
Miscellaneous
canSAR (ICR)RHOT1 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRHOT1
EVEXRHOT1
GoPubMedRHOT1
iHOPRHOT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:28:48 CEST 2017

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