RHOT2 (ras homolog family member T2)

2016-10-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
ARHT2,C16orf39,MIRO-2,MIRO2,RASL
FUSION GENES

Other Information

Locus ID:

NCBI: 89941
MIM: 613889
HGNC: 21169
Ensembl: ENSG00000140983

Variants:

dbSNP: 89941
ClinVar: 89941
TCGA: ENSG00000140983
COSMIC: RHOT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140983ENST00000315082Q8IXI1
ENSG00000140983ENST00000561929H3BST5
ENSG00000140983ENST00000561983H3BUX4
ENSG00000140983ENST00000562333H3BUX4
ENSG00000140983ENST00000563134I3L2C6
ENSG00000140983ENST00000563637H3BVI5
ENSG00000140983ENST00000566214H3BP40
ENSG00000140983ENST00000569197H3BU27
ENSG00000140983ENST00000570280H3BMP9

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220788852011PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.411
190981002008Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.204
166305622006The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.148
242562482013Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins.31
262597022015Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.26
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
276054302016Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.13
301115832018Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.10
304594462018GBF1 and Arf1 interact with Miro and regulate mitochondrial positioning within cells.5
307872022019Epigenetic signature: implications for mitochondrial quality control in human aging.4

Citation

Dessen P

RHOT2 (ras homolog family member T2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56494/rhot2