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RHOT2 (ras homolog family member T2)

Identity

Alias_namesC16orf39
ARHT2
chromosome 16 open reading frame 39
ras homolog gene family, member T2
Alias_symbol (synonym)MIRO-2
Other aliasMIRO2
RASL
HGNC (Hugo) RHOT2
LocusID (NCBI) 89941
Atlas_Id 56494
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 668083 and ends at 674174 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IGF1R (15q26.3) / RHOT2 (16p13.3)WDR90 (16p13.3) / RHOT2 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RHOT2   21169
Cards
Entrez_Gene (NCBI)RHOT2  89941  ras homolog family member T2
AliasesARHT2; C16orf39; MIRO-2; MIRO2; 
RASL
GeneCards (Weizmann)RHOT2
Ensembl hg19 (Hinxton)ENSG00000140983 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140983 [Gene_View]  chr16:668083-674174 [Contig_View]  RHOT2 [Vega]
ICGC DataPortalENSG00000140983
TCGA cBioPortalRHOT2
AceView (NCBI)RHOT2
Genatlas (Paris)RHOT2
WikiGenes89941
SOURCE (Princeton)RHOT2
Genetics Home Reference (NIH)RHOT2
Genomic and cartography
GoldenPath hg38 (UCSC)RHOT2  -     chr16:668083-674174 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RHOT2  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblRHOT2 - 16p13.3 [CytoView hg19]  RHOT2 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIRHOT2 [Mapview hg19]  RHOT2 [Mapview hg38]
OMIM613889   
Gene and transcription
Genbank (Entrez)AJ517413 AK024450 AK090426 AK308984 AL834163
RefSeq transcript (Entrez)NM_138769
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RHOT2
Cluster EST : UnigeneHs.513242 [ NCBI ]
CGAP (NCI)Hs.513242
Alternative Splicing GalleryENSG00000140983
Gene ExpressionRHOT2 [ NCBI-GEO ]   RHOT2 [ EBI - ARRAY_EXPRESS ]   RHOT2 [ SEEK ]   RHOT2 [ MEM ]
Gene Expression Viewer (FireBrowse)RHOT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89941
GTEX Portal (Tissue expression)RHOT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IXI1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IXI1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IXI1
Splice isoforms : SwissVarQ8IXI1
Catalytic activity : Enzyme3.6.5.- [ Enzyme-Expasy ]   3.6.5.-3.6.5.- [ IntEnz-EBI ]   3.6.5.- [ BRENDA ]   3.6.5.- [ KEGG ]   
PhosPhoSitePlusQ8IXI1
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    MIRO (PS51423)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_assoc_1    EF_hand_assoc_2    EF_hand_dom    MIRO_dom    Mt_Rho_GTPase    P-loop_NTPase    Rho_GTPase_2    Small_GTPase   
Domain families : Pfam (Sanger)EF_assoc_1 (PF08355)    EF_assoc_2 (PF08356)    Ras (PF00071)   
Domain families : Pfam (NCBI)pfam08355    pfam08356    pfam00071   
Conserved Domain (NCBI)RHOT2
DMDM Disease mutations89941
Blocks (Seattle)RHOT2
PDB (SRS)5KUT   
PDB (PDBSum)5KUT   
PDB (IMB)5KUT   
PDB (RSDB)5KUT   
Structural Biology KnowledgeBase5KUT   
SCOP (Structural Classification of Proteins)5KUT   
CATH (Classification of proteins structures)5KUT   
SuperfamilyQ8IXI1
Human Protein AtlasENSG00000140983
Peptide AtlasQ8IXI1
HPRD15248
IPIIPI00465059   IPI00759537   
Protein Interaction databases
DIP (DOE-UCLA)Q8IXI1
IntAct (EBI)Q8IXI1
FunCoupENSG00000140983
BioGRIDRHOT2
STRING (EMBL)RHOT2
ZODIACRHOT2
Ontologies - Pathways
QuickGOQ8IXI1
Ontology : AmiGOGTPase activity  calcium ion binding  protein binding  GTP binding  cytosol  plasma membrane  small GTPase mediated signal transduction  membrane  cellular homeostasis  integral component of mitochondrial outer membrane  mitochondrion transport along microtubule  regulation of small GTPase mediated signal transduction  extracellular exosome  mitochondrial outer membrane permeabilization  
Ontology : EGO-EBIGTPase activity  calcium ion binding  protein binding  GTP binding  cytosol  plasma membrane  small GTPase mediated signal transduction  membrane  cellular homeostasis  integral component of mitochondrial outer membrane  mitochondrion transport along microtubule  regulation of small GTPase mediated signal transduction  extracellular exosome  mitochondrial outer membrane permeabilization  
NDEx NetworkRHOT2
Atlas of Cancer Signalling NetworkRHOT2
Wikipedia pathwaysRHOT2
Orthology - Evolution
OrthoDB89941
GeneTree (enSembl)ENSG00000140983
Phylogenetic Trees/Animal Genes : TreeFamRHOT2
HOVERGENQ8IXI1
HOGENOMQ8IXI1
Homologs : HomoloGeneRHOT2
Homology/Alignments : Family Browser (UCSC)RHOT2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRHOT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RHOT2
dbVarRHOT2
ClinVarRHOT2
1000_GenomesRHOT2 
Exome Variant ServerRHOT2
ExAC (Exome Aggregation Consortium)RHOT2 (select the gene name)
Genetic variants : HAPMAP89941
Genomic Variants (DGV)RHOT2 [DGVbeta]
DECIPHERRHOT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRHOT2 
Mutations
ICGC Data PortalRHOT2 
TCGA Data PortalRHOT2 
Broad Tumor PortalRHOT2
OASIS PortalRHOT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRHOT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRHOT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch RHOT2
DgiDB (Drug Gene Interaction Database)RHOT2
DoCM (Curated mutations)RHOT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RHOT2 (select a term)
intoGenRHOT2
Cancer3DRHOT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613889   
Orphanet
MedgenRHOT2
Genetic Testing Registry RHOT2
NextProtQ8IXI1 [Medical]
TSGene89941
GENETestsRHOT2
Target ValidationRHOT2
Huge Navigator RHOT2 [HugePedia]
snp3D : Map Gene to Disease89941
BioCentury BCIQRHOT2
ClinGenRHOT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD89941
Chemical/Pharm GKB GenePA134889674
Clinical trialRHOT2
Miscellaneous
canSAR (ICR)RHOT2 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRHOT2
EVEXRHOT2
GoPubMedRHOT2
iHOPRHOT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:53:15 CEST 2017

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