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RHOU (ras homolog family member U)

Identity

Alias (NCBI)ARHU
CDC42L1
G28K
WRCH1
hG28K
HGNC (Hugo) RHOU
HGNC Alias symbWRCH-1
DJ646B12.2
FLJ10616
WRCH1
CDC42L1
hG28K
fJ646B12.2
HGNC Alias nameRyu GTPase
 Wnt-1 responsive Cdc42 homolog
 2310026M05Rik
 GTP-binding protein like 1
 CDC42-like GTPase
 GTP-binding protein SB128
 ras-like gene family member U
HGNC Previous nameARHU
HGNC Previous nameras homolog gene family, member U
LocusID (NCBI) 58480
Atlas_Id 45794
Location 1q42.13  [Link to chromosome band 1q42]
Location_base_pair Starts at 228735479 and ends at 228746664 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FLNA (Xq28) / RHOU (1q42.13)MAPK7 (17p11.2) / RHOU (1q42.13)NCOR1 (17p12) / RHOU (1q42.13)
RHOU (1q42.13) / RHOU (1q42.13)NCOR1 17p12 / RHOU 1q42.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RHOU   17794
Cards
Entrez_Gene (NCBI)RHOU    ras homolog family member U
AliasesARHU; CDC42L1; G28K; WRCH1; 
hG28K
GeneCards (Weizmann)RHOU
Ensembl hg19 (Hinxton)ENSG00000116574 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116574 [Gene_View]  ENSG00000116574 [Sequence]  chr1:228735479-228746664 [Contig_View]  RHOU [Vega]
ICGC DataPortalENSG00000116574
TCGA cBioPortalRHOU
AceView (NCBI)RHOU
Genatlas (Paris)RHOU
SOURCE (Princeton)RHOU
Genetics Home Reference (NIH)RHOU
Genomic and cartography
GoldenPath hg38 (UCSC)RHOU  -     chr1:228735479-228746664 +  1q42.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RHOU  -     1q42.13   [Description]    (hg19-Feb_2009)
GoldenPathRHOU - 1q42.13 [CytoView hg19]  RHOU - 1q42.13 [CytoView hg38]
ImmunoBaseENSG00000116574
Genome Data Viewer NCBIRHOU [Mapview hg19]  
OMIM606366   
Gene and transcription
Genbank (Entrez)AB051826 AB074878 AB209511 AF211836 AF251701
RefSeq transcript (Entrez)NM_021205
Consensus coding sequences : CCDS (NCBI)RHOU
Gene ExpressionRHOU [ NCBI-GEO ]   RHOU [ EBI - ARRAY_EXPRESS ]   RHOU [ SEEK ]   RHOU [ MEM ]
Gene Expression Viewer (FireBrowse)RHOU [ Firebrowse - Broad ]
GenevisibleExpression of RHOU in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)58480
GTEX Portal (Tissue expression)RHOU
Human Protein AtlasENSG00000116574-RHOU [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7L0Q8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7L0Q8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7L0Q8
PhosPhoSitePlusQ7L0Q8
Domaine pattern : Prosite (Expaxy)RHO (PS51420)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Rho   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RHOU
PDB (RSDB)2Q3H   
PDB Europe2Q3H   
PDB (PDBSum)2Q3H   
PDB (IMB)2Q3H   
Structural Biology KnowledgeBase2Q3H   
SCOP (Structural Classification of Proteins)2Q3H   
CATH (Classification of proteins structures)2Q3H   
SuperfamilyQ7L0Q8
AlphaFold pdb e-kbQ7L0Q8   
Human Protein Atlas [tissue]ENSG00000116574-RHOU [tissue]
HPRD06965
Protein Interaction databases
DIP (DOE-UCLA)Q7L0Q8
IntAct (EBI)Q7L0Q8
BioGRIDRHOU
STRING (EMBL)RHOU
ZODIACRHOU
Ontologies - Pathways
QuickGOQ7L0Q8
Ontology : AmiGOGolgi membrane  podosome  GTPase activity  protein binding  GTP binding  cytosol  plasma membrane  focal adhesion  endocytosis  cytoskeleton organization  regulation of cell shape  cell migration  cytokine-mediated signaling pathway  cell projection assembly  Cdc42 protein signal transduction  cell projection  metal ion binding  regulation of small GTPase mediated signal transduction  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIGolgi membrane  podosome  GTPase activity  protein binding  GTP binding  cytosol  plasma membrane  focal adhesion  endocytosis  cytoskeleton organization  regulation of cell shape  cell migration  cytokine-mediated signaling pathway  cell projection assembly  Cdc42 protein signal transduction  cell projection  metal ion binding  regulation of small GTPase mediated signal transduction  positive regulation of protein targeting to mitochondrion  
NDEx NetworkRHOU
Atlas of Cancer Signalling NetworkRHOU
Wikipedia pathwaysRHOU
Orthology - Evolution
OrthoDB58480
GeneTree (enSembl)ENSG00000116574
Phylogenetic Trees/Animal Genes : TreeFamRHOU
Homologs : HomoloGeneRHOU
Homology/Alignments : Family Browser (UCSC)RHOU
Gene fusions - Rearrangements
Fusion : QuiverRHOU
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRHOU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RHOU
dbVarRHOU
ClinVarRHOU
MonarchRHOU
1000_GenomesRHOU 
Exome Variant ServerRHOU
GNOMAD BrowserENSG00000116574
Varsome BrowserRHOU
ACMGRHOU variants
VarityQ7L0Q8
Genomic Variants (DGV)RHOU [DGVbeta]
DECIPHERRHOU [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRHOU 
Mutations
ICGC Data PortalRHOU 
TCGA Data PortalRHOU 
Broad Tumor PortalRHOU
OASIS PortalRHOU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRHOU  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRHOU
Mutations and Diseases : HGMDRHOU
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRHOU
DgiDB (Drug Gene Interaction Database)RHOU
DoCM (Curated mutations)RHOU
CIViC (Clinical Interpretations of Variants in Cancer)RHOU
Cancer3DRHOU
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606366   
Orphanet
DisGeNETRHOU
MedgenRHOU
Genetic Testing Registry RHOU
NextProtQ7L0Q8 [Medical]
GENETestsRHOU
Target ValidationRHOU
Huge Navigator RHOU [HugePedia]
ClinGenRHOU
Clinical trials, drugs, therapy
MyCancerGenomeRHOU
Protein Interactions : CTDRHOU
Pharm GKB GenePA38246
PharosQ7L0Q8
Clinical trialRHOU
Miscellaneous
canSAR (ICR)RHOU
HarmonizomeRHOU
DataMed IndexRHOU
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRHOU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:28:57 CEST 2021

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