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RHPN2 (rhophilin Rho GTPase binding protein 2)

Identity

Other aliasP76RBE
RHOBP
HGNC (Hugo) RHPN2
LocusID (NCBI) 85415
Atlas_Id 54582
Location 19q13.11  [Link to chromosome band 19q13]
Location_base_pair Starts at 32978592 and ends at 33064918 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP1R37 (19q13.32) / RHPN2 (19q13.11)RHPN2 (19q13.11) / ACTG1 (17q25.3)RHPN2 (19q13.11) / ANKRD27 (19q13.11)
RHPN2 (19q13.11) / CD2AP (6p12.3)RHPN2 (19q13.11) / CPNE8 (12q12)RHPN2 (19q13.11) / GRIN2D (19q13.33)
RHPN2 (19q13.11) / PEPD (19q13.11)RHPN2 (19q13.11) / VSTM2B (19q12)ZNF790 (19q13.12) / RHPN2 (19q13.11)
LRRC68 RHPN2 19q13.11RHPN2 19q13.11 / GRIN2D 19q13.33RHPN2 19q13.11 / PEPD 19q13.11
RHPN2 19q13.11 / VSTM2B 19q12ZNF790 19q13.12 / RHPN2 19q13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]
  Lung: Translocations in Adenocarcinoma
t(19;19)(q12;q13) RHPN2/VSTM2B
PPP1R37/RHPN2 (19q13)
RHPN2/GRIN2D (19q13)
RHPN2/PEPD (19q13)
ZNF790/RHPN2 (19q13)
RHPN2/ANKRD27 (19q13)


External links

Nomenclature
HGNC (Hugo)RHPN2   19974
Cards
Entrez_Gene (NCBI)RHPN2  85415  rhophilin Rho GTPase binding protein 2
AliasesP76RBE; RHOBP
GeneCards (Weizmann)RHPN2
Ensembl hg19 (Hinxton)ENSG00000131941 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131941 [Gene_View]  ENSG00000131941 [Sequence]  chr19:32978592-33064918 [Contig_View]  RHPN2 [Vega]
ICGC DataPortalENSG00000131941
TCGA cBioPortalRHPN2
AceView (NCBI)RHPN2
Genatlas (Paris)RHPN2
WikiGenes85415
SOURCE (Princeton)RHPN2
Genetics Home Reference (NIH)RHPN2
Genomic and cartography
GoldenPath hg38 (UCSC)RHPN2  -     chr19:32978592-33064918 -  19q13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RHPN2  -     19q13.11   [Description]    (hg19-Feb_2009)
EnsemblRHPN2 - 19q13.11 [CytoView hg19]  RHPN2 - 19q13.11 [CytoView hg38]
Mapping of homologs : NCBIRHPN2 [Mapview hg19]  RHPN2 [Mapview hg38]
OMIM617932   
Gene and transcription
Genbank (Entrez)AF268032 AF423421 AJ347750 AK026894 AK095001
RefSeq transcript (Entrez)NM_033103
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RHPN2
Cluster EST : UnigeneHs.466435 [ NCBI ]
CGAP (NCI)Hs.466435
Alternative Splicing GalleryENSG00000131941
Gene ExpressionRHPN2 [ NCBI-GEO ]   RHPN2 [ EBI - ARRAY_EXPRESS ]   RHPN2 [ SEEK ]   RHPN2 [ MEM ]
Gene Expression Viewer (FireBrowse)RHPN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85415
GTEX Portal (Tissue expression)RHPN2
Human Protein AtlasENSG00000131941-RHPN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IUC4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IUC4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IUC4
Splice isoforms : SwissVarQ8IUC4
PhosPhoSitePlusQ8IUC4
Domaine pattern : Prosite (Expaxy)BRO1 (PS51180)   
Domains : Interpro (EBI)BRO1_dom    BRO1_sf    HR1_rho-bd    HR1_rpt_sf    PDZ    PDZ_sf   
Domain families : Pfam (Sanger)BRO1 (PF03097)    HR1 (PF02185)   
Domain families : Pfam (NCBI)pfam03097    pfam02185   
Domain families : Smart (EMBL)BRO1 (SM01041)  Hr1 (SM00742)  PDZ (SM00228)  
Conserved Domain (NCBI)RHPN2
DMDM Disease mutations85415
Blocks (Seattle)RHPN2
PDB (RSDB)2VSV   
PDB Europe2VSV   
PDB (PDBSum)2VSV   
PDB (IMB)2VSV   
Structural Biology KnowledgeBase2VSV   
SCOP (Structural Classification of Proteins)2VSV   
CATH (Classification of proteins structures)2VSV   
SuperfamilyQ8IUC4
Human Protein Atlas [tissue]ENSG00000131941-RHPN2 [tissue]
Peptide AtlasQ8IUC4
HPRD10192
IPIIPI00292548   IPI01014170   IPI01012842   
Protein Interaction databases
DIP (DOE-UCLA)Q8IUC4
IntAct (EBI)Q8IUC4
FunCoupENSG00000131941
BioGRIDRHPN2
STRING (EMBL)RHPN2
ZODIACRHPN2
Ontologies - Pathways
QuickGOQ8IUC4
Ontology : AmiGOcytosol  signal transduction  perinuclear region of cytoplasm  
Ontology : EGO-EBIcytosol  signal transduction  perinuclear region of cytoplasm  
NDEx NetworkRHPN2
Atlas of Cancer Signalling NetworkRHPN2
Wikipedia pathwaysRHPN2
Orthology - Evolution
OrthoDB85415
GeneTree (enSembl)ENSG00000131941
Phylogenetic Trees/Animal Genes : TreeFamRHPN2
HOGENOMQ8IUC4
Homologs : HomoloGeneRHPN2
Homology/Alignments : Family Browser (UCSC)RHPN2
Gene fusions - Rearrangements
Fusion : MitelmanPPP1R37/RHPN2 [19q13.32/19q13.11]  [t(19;19)(q13;q13)]  
Fusion : MitelmanRHPN2/ANKRD27 [19q13.11/19q13.11]  [t(19;19)(q13;q13)]  
Fusion : MitelmanRHPN2/GRIN2D [19q13.11/19q13.33]  [t(19;19)(q13;q13)]  
Fusion : MitelmanRHPN2/PEPD [19q13.11/19q13.11]  [t(19;19)(q13;q13)]  
Fusion : MitelmanRHPN2/VSTM2B [19q13.11/19q12]  [t(19;19)(q12;q13)]  
Fusion : MitelmanZNF790/RHPN2 [19q13.12/19q13.11]  [t(19;19)(q13;q13)]  
Fusion PortalLRRC68 RHPN2 19q13.11 OV
Fusion PortalRHPN2 19q13.11 GRIN2D 19q13.33 OV
Fusion PortalRHPN2 19q13.11 PEPD 19q13.11 BLCA
Fusion PortalRHPN2 19q13.11 VSTM2B 19q12 LUAD
Fusion PortalZNF790 19q13.12 RHPN2 19q13.11 LGG
Fusion : QuiverRHPN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRHPN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RHPN2
dbVarRHPN2
ClinVarRHPN2
1000_GenomesRHPN2 
Exome Variant ServerRHPN2
ExAC (Exome Aggregation Consortium)ENSG00000131941
GNOMAD BrowserENSG00000131941
Varsome BrowserRHPN2
Genetic variants : HAPMAP85415
Genomic Variants (DGV)RHPN2 [DGVbeta]
DECIPHERRHPN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRHPN2 
Mutations
ICGC Data PortalRHPN2 
TCGA Data PortalRHPN2 
Broad Tumor PortalRHPN2
OASIS PortalRHPN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRHPN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRHPN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RHPN2
DgiDB (Drug Gene Interaction Database)RHPN2
DoCM (Curated mutations)RHPN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RHPN2 (select a term)
intoGenRHPN2
Cancer3DRHPN2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617932   
Orphanet
DisGeNETRHPN2
MedgenRHPN2
Genetic Testing Registry RHPN2
NextProtQ8IUC4 [Medical]
TSGene85415
GENETestsRHPN2
Target ValidationRHPN2
Huge Navigator RHPN2 [HugePedia]
snp3D : Map Gene to Disease85415
BioCentury BCIQRHPN2
ClinGenRHPN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85415
Chemical/Pharm GKB GenePA134979284
Clinical trialRHPN2
Miscellaneous
canSAR (ICR)RHPN2 (select the gene name)
DataMed IndexRHPN2
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRHPN2
EVEXRHPN2
GoPubMedRHPN2
iHOPRHPN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:35:22 CET 2019

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