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RIC1 (RIC1 homolog, RAB6A GEF complex partner 1)

Identity

Alias_namesKIAA1432
KIAA1432
RAB6A GEF complex partner 1
Alias_symbol (synonym)bA207C16.1
Other aliasCIP150
HGNC (Hugo) RIC1
LocusID (NCBI) 57589
Atlas_Id 54085
Location 9p24.1  [Link to chromosome band 9p24]
Location_base_pair Starts at 5629119 and ends at 5769454 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LIPA (10q23.31) / RIC1 (9p24.1)RIC1 (9p24.1) / AARD (8q24.11)RIC1 (9p24.1) / BNC2 (9p22.3)
RIC1 (9p24.1) / DCAF10 (9p13.2)RIC1 (9p24.1) / JAK2 (9p24.1)RIC1 (9p24.1) / TACC2 (10q26.13)
RPS27L (15q22.2) / RIC1 (9p24.1)TRAPPC2 (Xp22.2) / RIC1 (9p24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)RIC1   17686
Cards
Entrez_Gene (NCBI)RIC1  57589  RIC1 homolog, RAB6A GEF complex partner 1
AliasesCIP150; KIAA1432; bA207C16.1
GeneCards (Weizmann)RIC1
Ensembl hg19 (Hinxton)ENSG00000107036 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107036 [Gene_View]  chr9:5629119-5769454 [Contig_View]  RIC1 [Vega]
ICGC DataPortalENSG00000107036
TCGA cBioPortalRIC1
AceView (NCBI)RIC1
Genatlas (Paris)RIC1
WikiGenes57589
SOURCE (Princeton)RIC1
Genetics Home Reference (NIH)RIC1
Genomic and cartography
GoldenPath hg38 (UCSC)RIC1  -     chr9:5629119-5769454 +  9p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIC1  -     9p24.1   [Description]    (hg19-Feb_2009)
EnsemblRIC1 - 9p24.1 [CytoView hg19]  RIC1 - 9p24.1 [CytoView hg38]
Mapping of homologs : NCBIRIC1 [Mapview hg19]  RIC1 [Mapview hg38]
OMIM610354   
Gene and transcription
Genbank (Entrez)AA250979 AB037853 AB205401 AK022642 AK074150
RefSeq transcript (Entrez)NM_001135920 NM_001206557 NM_020829
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RIC1
Cluster EST : UnigeneHs.661509 [ NCBI ]
CGAP (NCI)Hs.661509
Alternative Splicing GalleryENSG00000107036
Gene ExpressionRIC1 [ NCBI-GEO ]   RIC1 [ EBI - ARRAY_EXPRESS ]   RIC1 [ SEEK ]   RIC1 [ MEM ]
Gene Expression Viewer (FireBrowse)RIC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57589
GTEX Portal (Tissue expression)RIC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4ADV7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4ADV7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4ADV7
Splice isoforms : SwissVarQ4ADV7
PhosPhoSitePlusQ4ADV7
Domains : Interpro (EBI)Ribosome_control_1    WD40/YVTN_repeat-like_dom    WD40_repeat_dom   
Domain families : Pfam (Sanger)RIC1 (PF07064)   
Domain families : Pfam (NCBI)pfam07064   
Conserved Domain (NCBI)RIC1
DMDM Disease mutations57589
Blocks (Seattle)RIC1
SuperfamilyQ4ADV7
Human Protein AtlasENSG00000107036
Peptide AtlasQ4ADV7
HPRD13858
IPIIPI00164719   IPI00940759   IPI00945675   IPI00884917   IPI01009450   IPI01018136   
Protein Interaction databases
DIP (DOE-UCLA)Q4ADV7
IntAct (EBI)Q4ADV7
FunCoupENSG00000107036
BioGRIDRIC1
STRING (EMBL)RIC1
ZODIACRIC1
Ontologies - Pathways
QuickGOQ4ADV7
Ontology : AmiGOGolgi membrane  protein binding  cytosol  cytosol  intracellular protein transport  membrane  integral component of membrane  Rab guanyl-nucleotide exchange factor activity  Rab GTPase binding  trans-Golgi network membrane  RIC1-RGP1 guanyl-nucleotide exchange factor complex  retrograde transport, endosome to Golgi  protein complex  positive regulation of GTPase activity  membrane organization  negative regulation of cellular protein catabolic process  
Ontology : EGO-EBIGolgi membrane  protein binding  cytosol  cytosol  intracellular protein transport  membrane  integral component of membrane  Rab guanyl-nucleotide exchange factor activity  Rab GTPase binding  trans-Golgi network membrane  RIC1-RGP1 guanyl-nucleotide exchange factor complex  retrograde transport, endosome to Golgi  protein complex  positive regulation of GTPase activity  membrane organization  negative regulation of cellular protein catabolic process  
NDEx NetworkRIC1
Atlas of Cancer Signalling NetworkRIC1
Wikipedia pathwaysRIC1
Orthology - Evolution
OrthoDB57589
GeneTree (enSembl)ENSG00000107036
Phylogenetic Trees/Animal Genes : TreeFamRIC1
HOVERGENQ4ADV7
HOGENOMQ4ADV7
Homologs : HomoloGeneRIC1
Homology/Alignments : Family Browser (UCSC)RIC1
Gene fusions - Rearrangements
Fusion : MitelmanRIC1/AARD [9p24.1/8q24.11]  
Fusion : MitelmanRIC1/BNC2 [9p24.1/9p22.3]  [t(9;9)(p22;p24)]  
Fusion : MitelmanRIC1/DCAF10 [9p24.1/9p13.2]  [t(9;9)(p13;p24)]  
Fusion : MitelmanRIC1/JAK2 [9p24.1/9p24.1]  [t(9;9)(p24;p24)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIC1
dbVarRIC1
ClinVarRIC1
1000_GenomesRIC1 
Exome Variant ServerRIC1
ExAC (Exome Aggregation Consortium)RIC1 (select the gene name)
Genetic variants : HAPMAP57589
Genomic Variants (DGV)RIC1 [DGVbeta]
DECIPHERRIC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIC1 
Mutations
ICGC Data PortalRIC1 
TCGA Data PortalRIC1 
Broad Tumor PortalRIC1
OASIS PortalRIC1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDRIC1
BioMutasearch RIC1
DgiDB (Drug Gene Interaction Database)RIC1
DoCM (Curated mutations)RIC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIC1 (select a term)
intoGenRIC1
Cancer3DRIC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610354   
Orphanet
MedgenRIC1
Genetic Testing Registry RIC1
NextProtQ4ADV7 [Medical]
TSGene57589
GENETestsRIC1
Target ValidationRIC1
Huge Navigator RIC1 [HugePedia]
snp3D : Map Gene to Disease57589
BioCentury BCIQRIC1
ClinGenRIC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57589
Chemical/Pharm GKB GenePA134884486
Clinical trialRIC1
Miscellaneous
canSAR (ICR)RIC1 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIC1
EVEXRIC1
GoPubMedRIC1
iHOPRIC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:53:16 CEST 2017

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