Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RIC3 (RIC3 acetylcholine receptor chaperone)

Identity

Alias (NCBI)AYST720
PRO1385
HGNC (Hugo) RIC3
HGNC Alias symbFLJ11608
PRO1385
AYST720
HGNC Previous nameresistance to inhibitors of cholinesterase 3 homolog (C. elegans)
LocusID (NCBI) 79608
Atlas_Id 72639
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 8106050 and ends at 8169094 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RIC3 (11p15.4) / TRB ()

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(7;11)(q34;p15) RIC3/TRBC2
t(7;11)(q34;p15) RIC3/TRB
t(7;11)(q34;p15) RIC3/TRBC2
t(7;11)(q34;p15) RIC3/TRB

External links

Nomenclature
HGNC (Hugo)RIC3   30338
Cards
Entrez_Gene (NCBI)RIC3  79608  RIC3 acetylcholine receptor chaperone
AliasesAYST720; PRO1385
GeneCards (Weizmann)RIC3
Ensembl hg19 (Hinxton)ENSG00000166405 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166405 [Gene_View]  ENSG00000166405 [Sequence]  chr11:8106050-8169094 [Contig_View]  RIC3 [Vega]
ICGC DataPortalENSG00000166405
TCGA cBioPortalRIC3
AceView (NCBI)RIC3
Genatlas (Paris)RIC3
WikiGenes79608
SOURCE (Princeton)RIC3
Genetics Home Reference (NIH)RIC3
Genomic and cartography
GoldenPath hg38 (UCSC)RIC3  -     chr11:8106050-8169094 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIC3  -     11p15.4   [Description]    (hg19-Feb_2009)
GoldenPathRIC3 - 11p15.4 [CytoView hg19]  RIC3 - 11p15.4 [CytoView hg38]
ImmunoBaseENSG00000166405
genome Data Viewer NCBIRIC3 [Mapview hg19]  
OMIM610509   
Gene and transcription
Genbank (Entrez)AK021670 AK022297 AK128611 AK296505 AK315379
RefSeq transcript (Entrez)NM_001135109 NM_001206671 NM_001206672 NM_001346690 NM_001346691 NM_001346692 NM_001346693 NM_001346694 NM_024557
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RIC3
Alternative Splicing GalleryENSG00000166405
Gene ExpressionRIC3 [ NCBI-GEO ]   RIC3 [ EBI - ARRAY_EXPRESS ]   RIC3 [ SEEK ]   RIC3 [ MEM ]
Gene Expression Viewer (FireBrowse)RIC3 [ Firebrowse - Broad ]
GenevisibleExpression of RIC3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79608
GTEX Portal (Tissue expression)RIC3
Human Protein AtlasENSG00000166405-RIC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z5B4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z5B4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z5B4
Splice isoforms : SwissVarQ7Z5B4
PhosPhoSitePlusQ7Z5B4
Domains : Interpro (EBI)Ric3    RIC3_N   
Domain families : Pfam (Sanger)RIC3 (PF15361)   
Domain families : Pfam (NCBI)pfam15361   
Conserved Domain (NCBI)RIC3
DMDM Disease mutations79608
Blocks (Seattle)RIC3
SuperfamilyQ7Z5B4
Human Protein Atlas [tissue]ENSG00000166405-RIC3 [tissue]
Peptide AtlasQ7Z5B4
HPRD17974
IPIIPI00152216   IPI00432408   IPI00384049   IPI00855702   IPI00922507   IPI00165593   IPI01014992   IPI00981563   IPI00979632   IPI00885143   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z5B4
IntAct (EBI)Q7Z5B4
FunCoupENSG00000166405
BioGRIDRIC3
STRING (EMBL)RIC3
ZODIACRIC3
Ontologies - Pathways
QuickGOQ7Z5B4
Ontology : AmiGOGolgi membrane  cell  endoplasmic reticulum membrane  protein folding  positive regulation of cytosolic calcium ion concentration  synaptic transmission, cholinergic  integral component of membrane  acetylcholine receptor binding  protein localization to cell surface  cellular protein-containing complex assembly  neuron projection  neuronal cell body  intracellular membrane-bounded organelle  protein binding involved in protein folding  synapse  
Ontology : EGO-EBIGolgi membrane  cell  endoplasmic reticulum membrane  protein folding  positive regulation of cytosolic calcium ion concentration  synaptic transmission, cholinergic  integral component of membrane  acetylcholine receptor binding  protein localization to cell surface  cellular protein-containing complex assembly  neuron projection  neuronal cell body  intracellular membrane-bounded organelle  protein binding involved in protein folding  synapse  
NDEx NetworkRIC3
Atlas of Cancer Signalling NetworkRIC3
Wikipedia pathwaysRIC3
Orthology - Evolution
OrthoDB79608
GeneTree (enSembl)ENSG00000166405
Phylogenetic Trees/Animal Genes : TreeFamRIC3
HOGENOMQ7Z5B4
Homologs : HomoloGeneRIC3
Homology/Alignments : Family Browser (UCSC)RIC3
Gene fusions - Rearrangements
Fusion : QuiverRIC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIC3
dbVarRIC3
ClinVarRIC3
1000_GenomesRIC3 
Exome Variant ServerRIC3
GNOMAD BrowserENSG00000166405
Varsome BrowserRIC3
Genetic variants : HAPMAP79608
Genomic Variants (DGV)RIC3 [DGVbeta]
DECIPHERRIC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIC3 
Mutations
ICGC Data PortalRIC3 
TCGA Data PortalRIC3 
Broad Tumor PortalRIC3
OASIS PortalRIC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIC3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRIC3
Mutations and Diseases : HGMDRIC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIC3
DgiDB (Drug Gene Interaction Database)RIC3
DoCM (Curated mutations)RIC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIC3 (select a term)
intoGenRIC3
Cancer3DRIC3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610509   
Orphanet
DisGeNETRIC3
MedgenRIC3
Genetic Testing Registry RIC3
NextProtQ7Z5B4 [Medical]
TSGene79608
GENETestsRIC3
Target ValidationRIC3
Huge Navigator RIC3 [HugePedia]
snp3D : Map Gene to Disease79608
BioCentury BCIQRIC3
ClinGenRIC3
Clinical trials, drugs, therapy
Protein Interactions : CTD79608
Pharm GKB GenePA142671066
Clinical trialRIC3
Miscellaneous
canSAR (ICR)RIC3 (select the gene name)
HarmonizomeRIC3
DataMed IndexRIC3
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIC3
EVEXRIC3
GoPubMedRIC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:25:16 CEST 2020
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