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RIC8A (RIC8 guanine nucleotide exchange factor A)

Identity

Alias_namesresistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
Alias_symbol (synonym)synembryn
synembryn-A
Other aliasRIC8
HGNC (Hugo) RIC8A
LocusID (NCBI) 60626
Atlas_Id 72640
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 207511 and ends at 215175 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RIC8A (11p15.5) / AGGF1 (5q13.3)RIC8A (11p15.5) / ORM1 (9q32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RIC8A   29550
Cards
Entrez_Gene (NCBI)RIC8A  60626  RIC8 guanine nucleotide exchange factor A
AliasesRIC8
GeneCards (Weizmann)RIC8A
Ensembl hg19 (Hinxton)ENSG00000177963 [Gene_View]  chr11:207511-215175 [Contig_View]  RIC8A [Vega]
Ensembl hg38 (Hinxton)ENSG00000177963 [Gene_View]  chr11:207511-215175 [Contig_View]  RIC8A [Vega]
ICGC DataPortalENSG00000177963
TCGA cBioPortalRIC8A
AceView (NCBI)RIC8A
Genatlas (Paris)RIC8A
WikiGenes60626
SOURCE (Princeton)RIC8A
Genetics Home Reference (NIH)RIC8A
Genomic and cartography
GoldenPath hg19 (UCSC)RIC8A  -     chr11:207511-215175 +  11p15.5   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RIC8A  -     11p15.5   [Description]    (hg38-Dec_2013)
EnsemblRIC8A - 11p15.5 [CytoView hg19]  RIC8A - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBIRIC8A [Mapview hg19]  RIC8A [Mapview hg38]
OMIM609146   
Gene and transcription
Genbank (Entrez)AK022870 AK026897 AK027090 AK027461 AK225420
RefSeq transcript (Entrez)NM_001286134 NM_021932
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)RIC8A
Cluster EST : UnigeneHs.592292 [ NCBI ]
CGAP (NCI)Hs.592292
Alternative Splicing GalleryENSG00000177963
Gene ExpressionRIC8A [ NCBI-GEO ]   RIC8A [ EBI - ARRAY_EXPRESS ]   RIC8A [ SEEK ]   RIC8A [ MEM ]
Gene Expression Viewer (FireBrowse)RIC8A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)60626
GTEX Portal (Tissue expression)RIC8A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPQ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPQ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPQ8
Splice isoforms : SwissVarQ9NPQ8
PhosPhoSitePlusQ9NPQ8
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Gua_nucleotide_exch_fac_Ric8    Synembryn   
Domain families : Pfam (Sanger)Ric8 (PF10165)   
Domain families : Pfam (NCBI)pfam10165   
Conserved Domain (NCBI)RIC8A
DMDM Disease mutations60626
Blocks (Seattle)RIC8A
SuperfamilyQ9NPQ8
Human Protein AtlasENSG00000177963
Peptide AtlasQ9NPQ8
HPRD12373
IPIIPI00746360   IPI00749304   IPI00100106   IPI00970851   IPI00977196   IPI00980312   IPI00976689   IPI00979629   IPI00976025   IPI00981188   IPI00985030   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPQ8
IntAct (EBI)Q9NPQ8
FunCoupENSG00000177963
BioGRIDRIC8A
STRING (EMBL)RIC8A
ZODIACRIC8A
Ontologies - Pathways
QuickGOQ9NPQ8
Ontology : AmiGOin utero embryonic development  vasculature development  G-protein alpha-subunit binding  guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  cytoplasm  cytoplasm  plasma membrane  plasma membrane  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  visual learning  cell migration involved in gastrulation  positive regulation of GTPase activity  cell-cell adhesion involved in gastrulation  basement membrane organization  
Ontology : EGO-EBIin utero embryonic development  vasculature development  G-protein alpha-subunit binding  guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  cytoplasm  cytoplasm  plasma membrane  plasma membrane  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  visual learning  cell migration involved in gastrulation  positive regulation of GTPase activity  cell-cell adhesion involved in gastrulation  basement membrane organization  
NDEx NetworkRIC8A
Atlas of Cancer Signalling NetworkRIC8A
Wikipedia pathwaysRIC8A
Orthology - Evolution
OrthoDB60626
GeneTree (enSembl)ENSG00000177963
Phylogenetic Trees/Animal Genes : TreeFamRIC8A
HOVERGENQ9NPQ8
HOGENOMQ9NPQ8
Homologs : HomoloGeneRIC8A
Homology/Alignments : Family Browser (UCSC)RIC8A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIC8A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIC8A
dbVarRIC8A
ClinVarRIC8A
1000_GenomesRIC8A 
Exome Variant ServerRIC8A
ExAC (Exome Aggregation Consortium)RIC8A (select the gene name)
Genetic variants : HAPMAP60626
Genomic Variants (DGV)RIC8A [DGVbeta]
DECIPHER (Syndromes)11:207511-215175  ENSG00000177963
CONAN: Copy Number AnalysisRIC8A 
Mutations
ICGC Data PortalRIC8A 
TCGA Data PortalRIC8A 
Broad Tumor PortalRIC8A
OASIS PortalRIC8A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIC8A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRIC8A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIC8A
DgiDB (Drug Gene Interaction Database)RIC8A
DoCM (Curated mutations)RIC8A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIC8A (select a term)
intoGenRIC8A
Cancer3DRIC8A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609146   
Orphanet
MedgenRIC8A
Genetic Testing Registry RIC8A
NextProtQ9NPQ8 [Medical]
TSGene60626
GENETestsRIC8A
Huge Navigator RIC8A [HugePedia]
snp3D : Map Gene to Disease60626
BioCentury BCIQRIC8A
ClinGenRIC8A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD60626
Chemical/Pharm GKB GenePA142671067
Clinical trialRIC8A
Miscellaneous
canSAR (ICR)RIC8A (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIC8A
EVEXRIC8A
GoPubMedRIC8A
iHOPRIC8A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:41:05 CET 2017

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