RIC8A (RIC8 guanine nucleotide exchange factor A)

2014-11-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
RIC8
FUSION GENES

Other Information

Locus ID:

NCBI: 60626
MIM: 609146
HGNC: 29550
Ensembl: ENSG00000177963

Variants:

dbSNP: 60626
ClinVar: 60626
TCGA: ENSG00000177963
COSMIC: RIC8A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177963ENST00000325207Q9NPQ8
ENSG00000177963ENST00000524854H0YE35
ENSG00000177963ENST00000526104Q9NPQ8
ENSG00000177963ENST00000526982E9PLE5
ENSG00000177963ENST00000527468E9PMP0
ENSG00000177963ENST00000527696Q9NPQ8
ENSG00000177963ENST00000527728H0YEN0
ENSG00000177963ENST00000528357E9PI04
ENSG00000177963ENST00000529275H0YC88
ENSG00000177963ENST00000530889E9PSI0
ENSG00000177963ENST00000626818E9PLE5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
204791292010Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.79
217717862011Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization.17
218807392011G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells.16
244661962014Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity.10
236653272013Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A.9
250748112014The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release.8
298440552018Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange.6
223841812012NCAM180 regulates Ric8A membrane localization and potentiates β-adrenergic response.3
254805672015Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα(i3).0

Citation

Dessen P

RIC8A (RIC8 guanine nucleotide exchange factor A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72640/ric8a