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RIC8B (RIC8 guanine nucleotide exchange factor B)

Identity

Alias (NCBI)RIC8
hSyn
HGNC (Hugo) RIC8B
HGNC Alias symbFLJ10620
hSyn
RIC8
HGNC Previous nameresistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
LocusID (NCBI) 55188
Atlas_Id 72641
Location 12q23.3  [Link to chromosome band 12q23]
Location_base_pair Starts at 106774556 and ends at 106889316 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RIC8B (12q23.3) / C11orf84 (11q13.1)RIC8B (12q23.3) / RFX4 (12q23.3)SYT1 (12q21.2) / RIC8B (12q23.3)
RIC8B RFX4RIC8B C11orf84

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(12;12)(q21;q23) SYT1/RIC8B
RIC8B/RFX4 (12q23)


External links

Nomenclature
HGNC (Hugo)RIC8B   25555
Cards
Entrez_Gene (NCBI)RIC8B  55188  RIC8 guanine nucleotide exchange factor B
AliasesRIC8; hSyn
GeneCards (Weizmann)RIC8B
Ensembl hg19 (Hinxton)ENSG00000111785 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111785 [Gene_View]  ENSG00000111785 [Sequence]  chr12:106774556-106889316 [Contig_View]  RIC8B [Vega]
ICGC DataPortalENSG00000111785
TCGA cBioPortalRIC8B
AceView (NCBI)RIC8B
Genatlas (Paris)RIC8B
WikiGenes55188
SOURCE (Princeton)RIC8B
Genetics Home Reference (NIH)RIC8B
Genomic and cartography
GoldenPath hg38 (UCSC)RIC8B  -     chr12:106774556-106889316 +  12q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIC8B  -     12q23.3   [Description]    (hg19-Feb_2009)
GoldenPathRIC8B - 12q23.3 [CytoView hg19]  RIC8B - 12q23.3 [CytoView hg38]
ImmunoBaseENSG00000111785
genome Data Viewer NCBIRIC8B [Mapview hg19]  
OMIM609147   
Gene and transcription
Genbank (Entrez)AK001482 AK128102 AW896637 AY221116 BC034220
RefSeq transcript (Entrez)NM_001330145 NM_001330146 NM_001330147 NM_001351361 NM_001351362 NM_001351363 NM_001351364 NM_001351366 NM_001351367 NM_018157
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RIC8B
Alternative Splicing GalleryENSG00000111785
Gene ExpressionRIC8B [ NCBI-GEO ]   RIC8B [ EBI - ARRAY_EXPRESS ]   RIC8B [ SEEK ]   RIC8B [ MEM ]
Gene Expression Viewer (FireBrowse)RIC8B [ Firebrowse - Broad ]
GenevisibleExpression of RIC8B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55188
GTEX Portal (Tissue expression)RIC8B
Human Protein AtlasENSG00000111785-RIC8B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVN3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NVN3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVN3
Splice isoforms : SwissVarQ9NVN3
PhosPhoSitePlusQ9NVN3
Domains : Interpro (EBI)ARM-type_fold    Gua_nucleotide_exch_fac_Ric8    Synembryn   
Domain families : Pfam (Sanger)Ric8 (PF10165)   
Domain families : Pfam (NCBI)pfam10165   
Conserved Domain (NCBI)RIC8B
DMDM Disease mutations55188
Blocks (Seattle)RIC8B
SuperfamilyQ9NVN3
Human Protein Atlas [tissue]ENSG00000111785-RIC8B [tissue]
Peptide AtlasQ9NVN3
HPRD16452
IPIIPI00018771   IPI00746112   IPI00443951   IPI00853186   IPI01021974   IPI01021737   IPI01021603   IPI01022760   IPI00853644   
Protein Interaction databases
DIP (DOE-UCLA)Q9NVN3
IntAct (EBI)Q9NVN3
FunCoupENSG00000111785
BioGRIDRIC8B
STRING (EMBL)RIC8B
ZODIACRIC8B
Ontologies - Pathways
QuickGOQ9NVN3
Ontology : AmiGOG-protein alpha-subunit binding  G-protein alpha-subunit binding  guanyl-nucleotide exchange factor activity  GTPase activator activity  cytoplasm  cytosol  plasma membrane  plasma membrane  cell cortex  G protein-coupled receptor signaling pathway  regulation of G protein-coupled receptor signaling pathway  positive regulation of GTPase activity  
Ontology : EGO-EBIG-protein alpha-subunit binding  G-protein alpha-subunit binding  guanyl-nucleotide exchange factor activity  GTPase activator activity  cytoplasm  cytosol  plasma membrane  plasma membrane  cell cortex  G protein-coupled receptor signaling pathway  regulation of G protein-coupled receptor signaling pathway  positive regulation of GTPase activity  
NDEx NetworkRIC8B
Atlas of Cancer Signalling NetworkRIC8B
Wikipedia pathwaysRIC8B
Orthology - Evolution
OrthoDB55188
GeneTree (enSembl)ENSG00000111785
Phylogenetic Trees/Animal Genes : TreeFamRIC8B
HOGENOMQ9NVN3
Homologs : HomoloGeneRIC8B
Homology/Alignments : Family Browser (UCSC)RIC8B
Gene fusions - Rearrangements
Fusion PortalRIC8B RFX4
Fusion PortalRIC8B C11orf84
Fusion : QuiverRIC8B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIC8B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIC8B
dbVarRIC8B
ClinVarRIC8B
1000_GenomesRIC8B 
Exome Variant ServerRIC8B
GNOMAD BrowserENSG00000111785
Varsome BrowserRIC8B
Genetic variants : HAPMAP55188
Genomic Variants (DGV)RIC8B [DGVbeta]
DECIPHERRIC8B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIC8B 
Mutations
ICGC Data PortalRIC8B 
TCGA Data PortalRIC8B 
Broad Tumor PortalRIC8B
OASIS PortalRIC8B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIC8B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRIC8B
Mutations and Diseases : HGMDRIC8B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIC8B
DgiDB (Drug Gene Interaction Database)RIC8B
DoCM (Curated mutations)RIC8B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIC8B (select a term)
intoGenRIC8B
Cancer3DRIC8B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609147   
Orphanet
DisGeNETRIC8B
MedgenRIC8B
Genetic Testing Registry RIC8B
NextProtQ9NVN3 [Medical]
TSGene55188
GENETestsRIC8B
Target ValidationRIC8B
Huge Navigator RIC8B [HugePedia]
snp3D : Map Gene to Disease55188
BioCentury BCIQRIC8B
ClinGenRIC8B
Clinical trials, drugs, therapy
Protein Interactions : CTD55188
Pharm GKB GenePA142671064
Clinical trialRIC8B
Miscellaneous
canSAR (ICR)RIC8B (select the gene name)
HarmonizomeRIC8B
DataMed IndexRIC8B
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIC8B
EVEXRIC8B
GoPubMedRIC8B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 16:25:17 CEST 2020

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