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RICTOR (RPTOR independent companion of MTOR complex 2)

Identity

Alias (NCBI)AVO3
PIA
hAVO3
HGNC (Hugo) RICTOR
HGNC Alias symbMGC39830
AVO3
PIA
KIAA1999
HGNC Alias namerapamycin-insensitive companion of mTOR
 pianissimo
HGNC Previous nameRPTOR independent companion of MTOR, complex 2
LocusID (NCBI) 253260
Atlas_Id 49986
Location 5p13.1  [Link to chromosome band 5p13]
Location_base_pair Starts at 38937921 and ends at 39074399 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RICTOR (5p13.1)::DTNBP1 (6p22.3)RICTOR (5p13.1)::FGF10 (5p12)RICTOR (5p13.1)::FYB (5p13.1)
RICTOR (5p13.1)::HCN1 (5p12)RICTOR (5p13.1)::RANBP3L (5p13.2)RICTOR 5p13.1::DTNBP1 6p22.3
RICTOR 5p13.1::FYB 5p13.1RICTOR 5p13.1::HCN1 5p12RICTOR 5p13.1::RANBP3L 5p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RICTOR   28611
Cards
Entrez_Gene (NCBI)RICTOR    RPTOR independent companion of MTOR complex 2
AliasesAVO3; PIA; hAVO3
GeneCards (Weizmann)RICTOR
Ensembl hg19 (Hinxton)ENSG00000164327 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164327 [Gene_View]  ENSG00000164327 [Sequence]  chr5:38937921-39074399 [Contig_View]  RICTOR [Vega]
ICGC DataPortalENSG00000164327
TCGA cBioPortalRICTOR
AceView (NCBI)RICTOR
Genatlas (Paris)RICTOR
SOURCE (Princeton)RICTOR
Genetics Home Reference (NIH)RICTOR
Genomic and cartography
GoldenPath hg38 (UCSC)RICTOR  -     chr5:38937921-39074399 -  5p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RICTOR  -     5p13.1   [Description]    (hg19-Feb_2009)
GoldenPathRICTOR - 5p13.1 [CytoView hg19]  RICTOR - 5p13.1 [CytoView hg38]
ImmunoBaseENSG00000164327
Genome Data Viewer NCBIRICTOR [Mapview hg19]  
OMIM609022   
Gene and transcription
Genbank (Entrez)AB082530 AK024327 AK094538 AK127305 AK128358
RefSeq transcript (Entrez)NM_001285439 NM_001285440 NM_152756
Consensus coding sequences : CCDS (NCBI)RICTOR
Gene ExpressionRICTOR [ NCBI-GEO ]   RICTOR [ EBI - ARRAY_EXPRESS ]   RICTOR [ SEEK ]   RICTOR [ MEM ]
Gene Expression Viewer (FireBrowse)RICTOR [ Firebrowse - Broad ]
GenevisibleExpression of RICTOR in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)253260
GTEX Portal (Tissue expression)RICTOR
Human Protein AtlasENSG00000164327-RICTOR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6R327   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6R327  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6R327
PhosPhoSitePlusQ6R327
Domains : Interpro (EBI)ARM-type_fold    Pianissimo_fam    Pianissimo_N    Rictor_IV    RICTOR_M    RICTOR_phospho    RICTOR_V   
Domain families : Pfam (Sanger)RasGEF_N_2 (PF14663)    RICTOR_M (PF14666)    RICTOR_N (PF14664)    RICTOR_phospho (PF14665)    RICTOR_V (PF14668)   
Domain families : Pfam (NCBI)pfam14663    pfam14666    pfam14664    pfam14665    pfam14668   
Domain families : Smart (EMBL)RICTOR_M (SM01307)  RICTOR_N (SM01308)  RICTOR_phospho (SM01309)  RICTOR_V (SM01310)  
Conserved Domain (NCBI)RICTOR
PDB (RSDB)5ZCS   
PDB Europe5ZCS   
PDB (PDBSum)5ZCS   
PDB (IMB)5ZCS   
Structural Biology KnowledgeBase5ZCS   
SCOP (Structural Classification of Proteins)5ZCS   
CATH (Classification of proteins structures)5ZCS   
SuperfamilyQ6R327
AlphaFold pdb e-kbQ6R327   
Human Protein Atlas [tissue]ENSG00000164327-RICTOR [tissue]
HPRD10682
Protein Interaction databases
DIP (DOE-UCLA)Q6R327
IntAct (EBI)Q6R327
BioGRIDRICTOR
STRING (EMBL)RICTOR
ZODIACRICTOR
Ontologies - Pathways
QuickGOQ6R327
Ontology : AmiGOpositive regulation of endothelial cell proliferation  protein binding  cytosol  embryo development ending in birth or egg hatching  regulation of gene expression  peptidyl-serine phosphorylation  protein kinase binding  positive regulation of actin filament polymerization  actin cytoskeleton reorganization  TORC2 complex  TORC2 complex  positive regulation of TOR signaling  activation of protein kinase B activity  regulation of actin cytoskeleton organization  regulation of peptidyl-serine phosphorylation  TORC2 signaling  ribosome binding  regulation of GTPase activity  protein serine/threonine kinase activator activity  regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  regulation of protein kinase B signaling  positive regulation of protein kinase B signaling  positive regulation of protein serine/threonine kinase activity  regulation of signal transduction by p53 class mediator  regulation of establishment of cell polarity  
Ontology : EGO-EBIpositive regulation of endothelial cell proliferation  protein binding  cytosol  embryo development ending in birth or egg hatching  regulation of gene expression  peptidyl-serine phosphorylation  protein kinase binding  positive regulation of actin filament polymerization  actin cytoskeleton reorganization  TORC2 complex  TORC2 complex  positive regulation of TOR signaling  activation of protein kinase B activity  regulation of actin cytoskeleton organization  regulation of peptidyl-serine phosphorylation  TORC2 signaling  ribosome binding  regulation of GTPase activity  protein serine/threonine kinase activator activity  regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  regulation of protein kinase B signaling  positive regulation of protein kinase B signaling  positive regulation of protein serine/threonine kinase activity  regulation of signal transduction by p53 class mediator  regulation of establishment of cell polarity  
Pathways : KEGGmTOR signaling pathway   
NDEx NetworkRICTOR
Atlas of Cancer Signalling NetworkRICTOR
Wikipedia pathwaysRICTOR
Orthology - Evolution
OrthoDB253260
GeneTree (enSembl)ENSG00000164327
Phylogenetic Trees/Animal Genes : TreeFamRICTOR
Homologs : HomoloGeneRICTOR
Homology/Alignments : Family Browser (UCSC)RICTOR
Gene fusions - Rearrangements
Fusion : MitelmanRICTOR::DTNBP1 [5p13.1/6p22.3]  
Fusion : MitelmanRICTOR::FGF10 [5p13.1/5p12]  
Fusion : MitelmanRICTOR::FYB [5p13.1/5p13.1]  
Fusion : MitelmanRICTOR::HCN1 [5p13.1/5p12]  
Fusion : MitelmanRICTOR::RANBP3L [5p13.1/5p13.2]  
Fusion : QuiverRICTOR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRICTOR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RICTOR
dbVarRICTOR
ClinVarRICTOR
MonarchRICTOR
1000_GenomesRICTOR 
Exome Variant ServerRICTOR
GNOMAD BrowserENSG00000164327
Varsome BrowserRICTOR
ACMGRICTOR variants
VarityQ6R327
Genomic Variants (DGV)RICTOR [DGVbeta]
DECIPHERRICTOR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRICTOR 
Mutations
ICGC Data PortalRICTOR 
TCGA Data PortalRICTOR 
Broad Tumor PortalRICTOR
OASIS PortalRICTOR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRICTOR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRICTOR
Mutations and Diseases : HGMDRICTOR
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRICTOR
DgiDB (Drug Gene Interaction Database)RICTOR
DoCM (Curated mutations)RICTOR
CIViC (Clinical Interpretations of Variants in Cancer)RICTOR
Cancer3DRICTOR
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609022   
Orphanet
DisGeNETRICTOR
MedgenRICTOR
Genetic Testing Registry RICTOR
NextProtQ6R327 [Medical]
GENETestsRICTOR
Target ValidationRICTOR
Huge Navigator RICTOR [HugePedia]
ClinGenRICTOR
Clinical trials, drugs, therapy
MyCancerGenomeRICTOR
Protein Interactions : CTDRICTOR
Pharm GKB GenePA165660455
PharosQ6R327
Clinical trialRICTOR
Miscellaneous
canSAR (ICR)RICTOR
HarmonizomeRICTOR
ARCHS4RICTOR
DataMed IndexRICTOR
Probes
Litterature
PubMed182 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRICTOR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:31:14 CET 2022

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