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RICTOR (RPTOR independent companion of MTOR complex 2)

Identity

Alias_namesRPTOR independent companion of MTOR
Alias_symbol (synonym)MGC39830
AVO3
PIA
KIAA1999
Other aliashAVO3
HGNC (Hugo) RICTOR
LocusID (NCBI) 253260
Atlas_Id 49986
Location 5p13.1  [Link to chromosome band 5p13]
Location_base_pair Starts at 38937921 and ends at 39074408 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RICTOR (5p13.1) / DTNBP1 (6p22.3)RICTOR (5p13.1) / FGF10 (5p12)RICTOR (5p13.1) / FYB (5p13.1)
RICTOR (5p13.1) / HCN1 (5p12)RICTOR (5p13.1) / RANBP3L (5p13.2)RICTOR 5p13.1 / DTNBP1 6p22.3
RICTOR 5p13.1 / FYB 5p13.1RICTOR 5p13.1 / HCN1 5p12RICTOR 5p13.1 / RANBP3L 5p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)RICTOR   28611
Cards
Entrez_Gene (NCBI)RICTOR  253260  RPTOR independent companion of MTOR complex 2
AliasesAVO3; PIA; hAVO3
GeneCards (Weizmann)RICTOR
Ensembl hg19 (Hinxton)ENSG00000164327 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164327 [Gene_View]  chr5:38937921-39074408 [Contig_View]  RICTOR [Vega]
ICGC DataPortalENSG00000164327
TCGA cBioPortalRICTOR
AceView (NCBI)RICTOR
Genatlas (Paris)RICTOR
WikiGenes253260
SOURCE (Princeton)RICTOR
Genetics Home Reference (NIH)RICTOR
Genomic and cartography
GoldenPath hg38 (UCSC)RICTOR  -     chr5:38937921-39074408 -  5p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RICTOR  -     5p13.1   [Description]    (hg19-Feb_2009)
EnsemblRICTOR - 5p13.1 [CytoView hg19]  RICTOR - 5p13.1 [CytoView hg38]
Mapping of homologs : NCBIRICTOR [Mapview hg19]  RICTOR [Mapview hg38]
OMIM609022   
Gene and transcription
Genbank (Entrez)AB082530 AK024327 AK094538 AK127305 AK128358
RefSeq transcript (Entrez)NM_001285439 NM_001285440 NM_152756
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RICTOR
Cluster EST : UnigeneHs.407926 [ NCBI ]
CGAP (NCI)Hs.407926
Alternative Splicing GalleryENSG00000164327
Gene ExpressionRICTOR [ NCBI-GEO ]   RICTOR [ EBI - ARRAY_EXPRESS ]   RICTOR [ SEEK ]   RICTOR [ MEM ]
Gene Expression Viewer (FireBrowse)RICTOR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)253260
GTEX Portal (Tissue expression)RICTOR
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6R327   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6R327  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6R327
Splice isoforms : SwissVarQ6R327
PhosPhoSitePlusQ6R327
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Pianissimo_fam    Pianissimo_N    Rictor_IV    RICTOR_M    RICTOR_phospho    RICTOR_V   
Domain families : Pfam (Sanger)RasGEF_N_2 (PF14663)    RICTOR_M (PF14666)    RICTOR_N (PF14664)    RICTOR_phospho (PF14665)    RICTOR_V (PF14668)   
Domain families : Pfam (NCBI)pfam14663    pfam14666    pfam14664    pfam14665    pfam14668   
Domain families : Smart (EMBL)RICTOR_M (SM01307)  RICTOR_N (SM01308)  RICTOR_phospho (SM01309)  RICTOR_V (SM01310)  
Conserved Domain (NCBI)RICTOR
DMDM Disease mutations253260
Blocks (Seattle)RICTOR
SuperfamilyQ6R327
Human Protein AtlasENSG00000164327
Peptide AtlasQ6R327
HPRD10682
IPIIPI00455500   IPI00166528   IPI00967923   IPI00967250   
Protein Interaction databases
DIP (DOE-UCLA)Q6R327
IntAct (EBI)Q6R327
FunCoupENSG00000164327
BioGRIDRICTOR
STRING (EMBL)RICTOR
ZODIACRICTOR
Ontologies - Pathways
QuickGOQ6R327
Ontology : AmiGOpositive regulation of endothelial cell proliferation  protein binding  cytosol  enzyme activator activity  embryo development  regulation of gene expression  peptidyl-serine phosphorylation  protein kinase binding  establishment of cell polarity  positive regulation of actin filament polymerization  establishment or maintenance of actin cytoskeleton polarity  T cell costimulation  actin cytoskeleton reorganization  TOR signaling  TORC2 complex  positive regulation of TOR signaling  regulation of actin cytoskeleton organization  regulation of peptidyl-serine phosphorylation  regulation of phosphorylation  ribosome binding  positive regulation of catalytic activity  regulation of GTPase activity  phosphatidylinositol-mediated signaling  regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  regulation of protein kinase B signaling  positive regulation of protein kinase B signaling  regulation of establishment of cell polarity  
Ontology : EGO-EBIpositive regulation of endothelial cell proliferation  protein binding  cytosol  enzyme activator activity  embryo development  regulation of gene expression  peptidyl-serine phosphorylation  protein kinase binding  establishment of cell polarity  positive regulation of actin filament polymerization  establishment or maintenance of actin cytoskeleton polarity  T cell costimulation  actin cytoskeleton reorganization  TOR signaling  TORC2 complex  positive regulation of TOR signaling  regulation of actin cytoskeleton organization  regulation of peptidyl-serine phosphorylation  regulation of phosphorylation  ribosome binding  positive regulation of catalytic activity  regulation of GTPase activity  phosphatidylinositol-mediated signaling  regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  regulation of protein kinase B signaling  positive regulation of protein kinase B signaling  regulation of establishment of cell polarity  
Pathways : KEGGmTOR signaling pathway   
NDEx NetworkRICTOR
Atlas of Cancer Signalling NetworkRICTOR
Wikipedia pathwaysRICTOR
Orthology - Evolution
OrthoDB253260
GeneTree (enSembl)ENSG00000164327
Phylogenetic Trees/Animal Genes : TreeFamRICTOR
HOVERGENQ6R327
HOGENOMQ6R327
Homologs : HomoloGeneRICTOR
Homology/Alignments : Family Browser (UCSC)RICTOR
Gene fusions - Rearrangements
Fusion : MitelmanRICTOR/DTNBP1 [5p13.1/6p22.3]  
Fusion : MitelmanRICTOR/FGF10 [5p13.1/5p12]  [t(5;5)(p12;p13)]  
Fusion : MitelmanRICTOR/FYB [5p13.1/5p13.1]  [t(5;5)(p13;p13)]  
Fusion : MitelmanRICTOR/HCN1 [5p13.1/5p12]  [t(5;5)(p12;p13)]  
Fusion : MitelmanRICTOR/RANBP3L [5p13.1/5p13.2]  [t(5;5)(p13;p13)]  
Fusion: TCGARICTOR 5p13.1 DTNBP1 6p22.3 LUAD
Fusion: TCGARICTOR 5p13.1 FYB 5p13.1 LUAD LUSC
Fusion: TCGARICTOR 5p13.1 HCN1 5p12 BLCA
Fusion: TCGARICTOR 5p13.1 RANBP3L 5p13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRICTOR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RICTOR
dbVarRICTOR
ClinVarRICTOR
1000_GenomesRICTOR 
Exome Variant ServerRICTOR
ExAC (Exome Aggregation Consortium)RICTOR (select the gene name)
Genetic variants : HAPMAP253260
Genomic Variants (DGV)RICTOR [DGVbeta]
DECIPHERRICTOR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRICTOR 
Mutations
ICGC Data PortalRICTOR 
TCGA Data PortalRICTOR 
Broad Tumor PortalRICTOR
OASIS PortalRICTOR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRICTOR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRICTOR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RICTOR
DgiDB (Drug Gene Interaction Database)RICTOR
DoCM (Curated mutations)RICTOR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RICTOR (select a term)
intoGenRICTOR
Cancer3DRICTOR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609022   
Orphanet
MedgenRICTOR
Genetic Testing Registry RICTOR
NextProtQ6R327 [Medical]
TSGene253260
GENETestsRICTOR
Huge Navigator RICTOR [HugePedia]
snp3D : Map Gene to Disease253260
BioCentury BCIQRICTOR
ClinGenRICTOR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD253260
Chemical/Pharm GKB GenePA165660455
Clinical trialRICTOR
Miscellaneous
canSAR (ICR)RICTOR (select the gene name)
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRICTOR
EVEXRICTOR
GoPubMedRICTOR
iHOPRICTOR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:35:00 CEST 2017

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