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RIF1 (replication timing regulatory factor 1)

Identity

Alias_namesRAP1 interacting factor homolog (yeast)
Alias_symbol (synonym)FLJ12870
FLJ10599
Other alias-
HGNC (Hugo) RIF1
LocusID (NCBI) 55183
Atlas_Id 51082
Location 2q23.3  [Link to chromosome band 2q23]
Location_base_pair Starts at 151409883 and ends at 151477346 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM49A (2p24.2) / RIF1 (2q23.3)RIF1 (2q23.3) / IFT80 (3q25.33)RIF1 (2q23.3) / LYPD6 (2q23.2)
RIF1 (2q23.3) / PKD1L1 (7p12.3)RIF1 (2q23.3) / RIF1 (2q23.3)TSNARE1 (8q24.3) / RIF1 (2q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RIF1   23207
Cards
Entrez_Gene (NCBI)RIF1  55183  replication timing regulatory factor 1
Aliases
GeneCards (Weizmann)RIF1
Ensembl hg19 (Hinxton)ENSG00000080345 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080345 [Gene_View]  chr2:151409883-151477346 [Contig_View]  RIF1 [Vega]
ICGC DataPortalENSG00000080345
TCGA cBioPortalRIF1
AceView (NCBI)RIF1
Genatlas (Paris)RIF1
WikiGenes55183
SOURCE (Princeton)RIF1
Genetics Home Reference (NIH)RIF1
Genomic and cartography
GoldenPath hg38 (UCSC)RIF1  -     chr2:151409883-151477346 +  2q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIF1  -     2q23.3   [Description]    (hg19-Feb_2009)
EnsemblRIF1 - 2q23.3 [CytoView hg19]  RIF1 - 2q23.3 [CytoView hg38]
Mapping of homologs : NCBIRIF1 [Mapview hg19]  RIF1 [Mapview hg38]
OMIM608952   
Gene and transcription
Genbank (Entrez)AK000323 AK001461 AK022932 AK024033 AK074349
RefSeq transcript (Entrez)NM_001177663 NM_001177664 NM_001177665 NM_018151
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RIF1
Cluster EST : UnigeneHs.735592 [ NCBI ]
CGAP (NCI)Hs.735592
Alternative Splicing GalleryENSG00000080345
Gene ExpressionRIF1 [ NCBI-GEO ]   RIF1 [ EBI - ARRAY_EXPRESS ]   RIF1 [ SEEK ]   RIF1 [ MEM ]
Gene Expression Viewer (FireBrowse)RIF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55183
GTEX Portal (Tissue expression)RIF1
Human Protein AtlasENSG00000080345-RIF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5UIP0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5UIP0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5UIP0
Splice isoforms : SwissVarQ5UIP0
PhosPhoSitePlusQ5UIP0
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Rif1    Rif1_N   
Domain families : Pfam (Sanger)Rif1_N (PF12231)   
Domain families : Pfam (NCBI)pfam12231   
Conserved Domain (NCBI)RIF1
DMDM Disease mutations55183
Blocks (Seattle)RIF1
SuperfamilyQ5UIP0
Human Protein Atlas [tissue]ENSG00000080345-RIF1 [tissue]
Peptide AtlasQ5UIP0
HPRD10603
IPIIPI00293845   IPI00375454   IPI00964181   IPI00910844   IPI00927193   
Protein Interaction databases
DIP (DOE-UCLA)Q5UIP0
IntAct (EBI)Q5UIP0
FunCoupENSG00000080345
BioGRIDRIF1
STRING (EMBL)RIF1
ZODIACRIF1
Ontologies - Pathways
QuickGOQ5UIP0
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  telomere maintenance  chromosome, telomeric region  nuclear chromatin  condensed chromosome  female pronucleus  male pronucleus  protein binding  nucleus  nucleoplasm  cytoplasm  plasma membrane  double-strand break repair via nonhomologous end joining  chromatin silencing at telomere  cellular response to DNA damage stimulus  cell cycle  nuclear body  stem cell population maintenance  nuclear membrane  site of double-strand break  telomere maintenance in response to DNA damage  positive regulation of isotype switching  spindle midzone  positive regulation of histone H3-K9 methylation  negative regulation of double-strand break repair via homologous recombination  positive regulation of double-strand break repair via nonhomologous end joining  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  telomere maintenance  chromosome, telomeric region  nuclear chromatin  condensed chromosome  female pronucleus  male pronucleus  protein binding  nucleus  nucleoplasm  cytoplasm  plasma membrane  double-strand break repair via nonhomologous end joining  chromatin silencing at telomere  cellular response to DNA damage stimulus  cell cycle  nuclear body  stem cell population maintenance  nuclear membrane  site of double-strand break  telomere maintenance in response to DNA damage  positive regulation of isotype switching  spindle midzone  positive regulation of histone H3-K9 methylation  negative regulation of double-strand break repair via homologous recombination  positive regulation of double-strand break repair via nonhomologous end joining  
NDEx NetworkRIF1
Atlas of Cancer Signalling NetworkRIF1
Wikipedia pathwaysRIF1
Orthology - Evolution
OrthoDB55183
GeneTree (enSembl)ENSG00000080345
Phylogenetic Trees/Animal Genes : TreeFamRIF1
HOVERGENQ5UIP0
HOGENOMQ5UIP0
Homologs : HomoloGeneRIF1
Homology/Alignments : Family Browser (UCSC)RIF1
Gene fusions - Rearrangements
Fusion : MitelmanFAM49A/RIF1 [2p24.2/2q23.3]  [t(2;2)(p24;q23)]  
Fusion : MitelmanRIF1/PKD1L1 [2q23.3/7p12.3]  [t(2;7)(q23;p12)]  
Tumor Fusion PortalRIF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIF1
dbVarRIF1
ClinVarRIF1
1000_GenomesRIF1 
Exome Variant ServerRIF1
ExAC (Exome Aggregation Consortium)ENSG00000080345
GNOMAD BrowserENSG00000080345
Genetic variants : HAPMAP55183
Genomic Variants (DGV)RIF1 [DGVbeta]
DECIPHERRIF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIF1 
Mutations
ICGC Data PortalRIF1 
TCGA Data PortalRIF1 
Broad Tumor PortalRIF1
OASIS PortalRIF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRIF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIF1
DgiDB (Drug Gene Interaction Database)RIF1
DoCM (Curated mutations)RIF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIF1 (select a term)
intoGenRIF1
Cancer3DRIF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608952   
Orphanet
DisGeNETRIF1
MedgenRIF1
Genetic Testing Registry RIF1
NextProtQ5UIP0 [Medical]
TSGene55183
GENETestsRIF1
Target ValidationRIF1
Huge Navigator RIF1 [HugePedia]
snp3D : Map Gene to Disease55183
BioCentury BCIQRIF1
ClinGenRIF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55183
Chemical/Pharm GKB GenePA134933858
Clinical trialRIF1
Miscellaneous
canSAR (ICR)RIF1 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIF1
EVEXRIF1
GoPubMedRIF1
iHOPRIF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:32:25 CET 2017

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