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RIMS2 (regulating synaptic membrane exocytosis 2)

Identity

Alias (NCBI)CRSDS
OBOE
RAB3IP3
RIM2
HGNC (Hugo) RIMS2
HGNC Alias symbKIAA0751
RIM2
OBOE
HGNC Previous nameRAB3IP3
HGNC Previous nameRAB3 interacting protein 3
LocusID (NCBI) 9699
Atlas_Id 47396
Location 8q22.3  [Link to chromosome band 8q22]
Location_base_pair Starts at 103819220 and ends at 104256094 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAALC (8q22.3) / RIMS2 (8q22.3)CSMD3 (8q23.3) / RIMS2 (8q22.3)FXR1 (3q26.33) / RIMS2 (8q22.3)
LRP12 (8q22.3) / RIMS2 (8q22.3)PHLDB2 (3q13.2) / RIMS2 (8q22.3)RIMS2 (8q22.3) / ATP6V1C1 (8q22.3)
RIMS2 (8q22.3) / BAALC (8q22.3)RIMS2 (8q22.3) / ODF1 (8q22.3)RIMS2 (8q22.3) / PTGIS (20q13.13)
RIMS2 (8q22.3) / RIMS2 (8q22.3)ZNF462 (9q31.2) / RIMS2 (8q22.3)CSMD3 8q23.3 / RIMS2 8q22.3
FXR1 3q26.33 / RIMS2 8q22.3LRP12 8q22.3 / RIMS2 8q22.3PHLDB2 3q13.2 / RIMS2 8q22.3
RIMS2 8q22.3 / BAALC 8q22.3RIMS2 8q22.3 / ODF1 8q22.3RIMS2 8q22.3 / PTGIS 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RIMS2   17283
Cards
Entrez_Gene (NCBI)RIMS2    regulating synaptic membrane exocytosis 2
AliasesCRSDS; OBOE; RAB3IP3; RIM2
GeneCards (Weizmann)RIMS2
Ensembl hg19 (Hinxton)ENSG00000176406 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176406 [Gene_View]  ENSG00000176406 [Sequence]  chr8:103819220-104256094 [Contig_View]  RIMS2 [Vega]
ICGC DataPortalENSG00000176406
TCGA cBioPortalRIMS2
AceView (NCBI)RIMS2
Genatlas (Paris)RIMS2
SOURCE (Princeton)RIMS2
Genetics Home Reference (NIH)RIMS2
Genomic and cartography
GoldenPath hg38 (UCSC)RIMS2  -     chr8:103819220-104256094 +  8q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIMS2  -     8q22.3   [Description]    (hg19-Feb_2009)
GoldenPathRIMS2 - 8q22.3 [CytoView hg19]  RIMS2 - 8q22.3 [CytoView hg38]
ImmunoBaseENSG00000176406
Genome Data Viewer NCBIRIMS2 [Mapview hg19]  
OMIM606630   618970   
Gene and transcription
Genbank (Entrez)AB018294 AF007156 AK126939 AK307790 AK308831
RefSeq transcript (Entrez)NM_001100117 NM_001282881 NM_001282882 NM_001348484 NM_001348485 NM_001348486 NM_001348487 NM_001348488 NM_001348489 NM_001348490 NM_001348491 NM_001348492 NM_001348493 NM_001348494 NM_001348495 NM_001348496 NM_001348497 NM_001348498 NM_001348499 NM_001348500 NM_001348501 NM_001348502 NM_001348503 NM_001348504 NM_001348505 NM_001348506 NM_001348507 NM_001348508 NM_001348509 NM_014677
Consensus coding sequences : CCDS (NCBI)RIMS2
Gene ExpressionRIMS2 [ NCBI-GEO ]   RIMS2 [ EBI - ARRAY_EXPRESS ]   RIMS2 [ SEEK ]   RIMS2 [ MEM ]
Gene Expression Viewer (FireBrowse)RIMS2 [ Firebrowse - Broad ]
GenevisibleExpression of RIMS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9699
GTEX Portal (Tissue expression)RIMS2
Human Protein AtlasENSG00000176406-RIMS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQ26   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQ26  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQ26
PhosPhoSitePlusQ9UQ26
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PDZ (PS50106)    RABBD (PS50916)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)C2_dom    C2_domain_sf    FYVE_2    PDZ    PDZ_6    PDZ_sf    Rab_BD    Rim-like    RIM2    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)C2 (PF00168)    FYVE_2 (PF02318)    PDZ_6 (PF17820)   
Domain families : Pfam (NCBI)pfam00168    pfam02318    pfam17820   
Domain families : Smart (EMBL)C2 (SM00239)  PDZ (SM00228)  
Conserved Domain (NCBI)RIMS2
PDB (RSDB)1V27    1WFG   
PDB Europe1V27    1WFG   
PDB (PDBSum)1V27    1WFG   
PDB (IMB)1V27    1WFG   
Structural Biology KnowledgeBase1V27    1WFG   
SCOP (Structural Classification of Proteins)1V27    1WFG   
CATH (Classification of proteins structures)1V27    1WFG   
SuperfamilyQ9UQ26
AlphaFold pdb e-kbQ9UQ26   
Human Protein Atlas [tissue]ENSG00000176406-RIMS2 [tissue]
HPRD09436
Protein Interaction databases
DIP (DOE-UCLA)Q9UQ26
IntAct (EBI)Q9UQ26
BioGRIDRIMS2
STRING (EMBL)RIMS2
ZODIACRIMS2
Ontologies - Pathways
QuickGOQ9UQ26
Ontology : AmiGOprotein binding  intracellular protein transport  positive regulation of gene expression  calcium-ion regulated exocytosis  regulation of exocytosis  cAMP-mediated signaling  insulin secretion  cell differentiation  small GTPase binding  regulation of membrane potential  regulation of membrane potential  presynaptic membrane  cell projection  ion channel binding  ion channel binding  metal ion binding  regulation of synaptic plasticity  presynaptic active zone  cytoskeleton of presynaptic active zone  calcium ion-regulated exocytosis of neurotransmitter  calcium ion-regulated exocytosis of neurotransmitter  positive regulation of synaptic transmission  spontaneous neurotransmitter secretion  extracellular exosome  positive regulation of inhibitory postsynaptic potential  positive regulation of dendrite extension  regulation of synaptic vesicle exocytosis  positive regulation of excitatory postsynaptic potential  
Ontology : EGO-EBIprotein binding  intracellular protein transport  positive regulation of gene expression  calcium-ion regulated exocytosis  regulation of exocytosis  cAMP-mediated signaling  insulin secretion  cell differentiation  small GTPase binding  regulation of membrane potential  regulation of membrane potential  presynaptic membrane  cell projection  ion channel binding  ion channel binding  metal ion binding  regulation of synaptic plasticity  presynaptic active zone  cytoskeleton of presynaptic active zone  calcium ion-regulated exocytosis of neurotransmitter  calcium ion-regulated exocytosis of neurotransmitter  positive regulation of synaptic transmission  spontaneous neurotransmitter secretion  extracellular exosome  positive regulation of inhibitory postsynaptic potential  positive regulation of dendrite extension  regulation of synaptic vesicle exocytosis  positive regulation of excitatory postsynaptic potential  
Pathways : KEGGInsulin secretion   
NDEx NetworkRIMS2
Atlas of Cancer Signalling NetworkRIMS2
Wikipedia pathwaysRIMS2
Orthology - Evolution
OrthoDB9699
GeneTree (enSembl)ENSG00000176406
Phylogenetic Trees/Animal Genes : TreeFamRIMS2
Homologs : HomoloGeneRIMS2
Homology/Alignments : Family Browser (UCSC)RIMS2
Gene fusions - Rearrangements
Fusion : MitelmanCSMD3/RIMS2 [8q23.3/8q22.3]  
Fusion : MitelmanFXR1/RIMS2 [3q26.33/8q22.3]  
Fusion : MitelmanLRP12/RIMS2 [8q22.3/8q22.3]  
Fusion : MitelmanPHLDB2/RIMS2 [3q13.2/8q22.3]  
Fusion : MitelmanRIMS2/ATP6V1C1 [8q22.3/8q22.3]  
Fusion : MitelmanRIMS2/BAALC [8q22.3/8q22.3]  
Fusion : MitelmanRIMS2/ODF1 [8q22.3/8q22.3]  
Fusion : MitelmanRIMS2/PTGIS [8q22.3/20q13.13]  
Fusion Cancer (Beijing)BAALC [8q22.3]  -  RIMS2 [8q22.3]  [FUSC000516]  [FUSC000516]
Fusion Cancer (Beijing)RIMS2 [8q22.3]  -  BAALC [8q22.3]  [FUSC000573]  [FUSC000573]
Fusion : QuiverRIMS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIMS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIMS2
dbVarRIMS2
ClinVarRIMS2
MonarchRIMS2
1000_GenomesRIMS2 
Exome Variant ServerRIMS2
GNOMAD BrowserENSG00000176406
Varsome BrowserRIMS2
ACMGRIMS2 variants
VarityQ9UQ26
Genomic Variants (DGV)RIMS2 [DGVbeta]
DECIPHERRIMS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIMS2 
Mutations
ICGC Data PortalRIMS2 
TCGA Data PortalRIMS2 
Broad Tumor PortalRIMS2
OASIS PortalRIMS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIMS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRIMS2
Mutations and Diseases : HGMDRIMS2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRIMS2
DgiDB (Drug Gene Interaction Database)RIMS2
DoCM (Curated mutations)RIMS2
CIViC (Clinical Interpretations of Variants in Cancer)RIMS2
Cancer3DRIMS2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606630    618970   
Orphanet
DisGeNETRIMS2
MedgenRIMS2
Genetic Testing Registry RIMS2
NextProtQ9UQ26 [Medical]
GENETestsRIMS2
Target ValidationRIMS2
Huge Navigator RIMS2 [HugePedia]
ClinGenRIMS2
Clinical trials, drugs, therapy
MyCancerGenomeRIMS2
Protein Interactions : CTDRIMS2
Pharm GKB GenePA38445
PharosQ9UQ26
Clinical trialRIMS2
Miscellaneous
canSAR (ICR)RIMS2
HarmonizomeRIMS2
DataMed IndexRIMS2
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRIMS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:28:59 CEST 2021

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