Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54453
MIM: 610222
HGNC: 18750
Ensembl: ENSG00000132669
Variants:
dbSNP: 54453
ClinVar: 54453
TCGA: ENSG00000132669
COSMIC: RIN2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000132669 | ENST00000255006 | Q8WYP3 |
| ENSG00000132669 | ENST00000440354 | E7EPJ1 |
| ENSG00000132669 | ENST00000648440 | Q8WYP3 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Vesicle-mediated transport | REACTOME | R-HSA-5653656 |
| Membrane Trafficking | REACTOME | R-HSA-199991 |
| RAB GEFs exchange GTP for GDP on RABs | REACTOME | R-HSA-8876198 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36520196 | 2023 | Rare adult pilocytic astrocytoma of the septum pellucidum with novel RIN2::BRAF fusion. | 1 |
| 37827343 | 2023 | NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling. | 0 |
| 36520196 | 2023 | Rare adult pilocytic astrocytoma of the septum pellucidum with novel RIN2::BRAF fusion. | 1 |
| 37827343 | 2023 | NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling. | 0 |
| 33983539 | 2021 | The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis. | 16 |
| 33983539 | 2021 | The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis. | 16 |
| 30769224 | 2020 | Leukoencephalopathy in RIN2 syndrome: Novel mutation and expansion of clinical spectrum. | 1 |
| 30769224 | 2020 | Leukoencephalopathy in RIN2 syndrome: Novel mutation and expansion of clinical spectrum. | 1 |
| 29099266 | 2018 | Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration. | 6 |
| 29099266 | 2018 | Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration. | 6 |
| 27277385 | 2016 | RIN2 syndrome: Expanding the clinical phenotype. | 3 |
| 27277385 | 2016 | RIN2 syndrome: Expanding the clinical phenotype. | 3 |
| 24449201 | 2014 | Newly described clinical features in two siblings with MACS syndrome and a novel mutation in RIN2. | 3 |
| 24449201 | 2014 | Newly described clinical features in two siblings with MACS syndrome and a novel mutation in RIN2. | 3 |
| 20424861 | 2010 | The RIN2 syndrome: a new autosomal recessive connective tissue disorder caused by deficiency of Ras and Rab interactor 2 (RIN2). | 19 |
Citation
Dessen P
RIN2 (Ras and Rab interactor 2)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43469/rin2
