RING1 (ring finger protein 1)

2003-02-01  

Identity

HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
RING1A,RNF1
FUSION GENES

Other Information

Locus ID:

NCBI: 6015
MIM: 602045
HGNC: 10018
Ensembl: ENSG00000204227

Variants:

dbSNP: 6015
ClinVar: 6015
TCGA: ENSG00000204227
COSMIC: RING1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204227ENST00000374656Q06587
ENSG00000204227ENST00000374656A0A1U9X8F2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190471282008Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.99
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
171348222007Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features.62
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
211254012011Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring.33
208005742010Regulation of the Polycomb protein RING1B ubiquitination by USP7.30
194128912009Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression.26
208197782010MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.21
188302482009Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B.15
305187602018Long non-coding RNA C5orf66-AS1 promotes cell proliferation in cervical cancer by targeting miR-637/RING1 axis.13

Citation

Dessen P

RING1 (ring finger protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42117/ring1