Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RIOK1 (RIO kinase 1)

Identity

Alias_namesRIO kinase 1 (yeast)
Alias_symbol (synonym)AD034
FLJ30006
bA288G3.1
RRP10
Other aliasRIO1
HGNC (Hugo) RIOK1
LocusID (NCBI) 83732
Atlas_Id 43470
Location 6p24.3  [Link to chromosome band 6p24]
Location_base_pair Starts at 7389829 and ends at 7418037 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RIOK1 (6p24.3) / IQCJ-SCHIP1 (3q25.32)UHRF1BP1 (6p21.31) / RIOK1 (6p24.3)UHRF1BP1 6p21.31 / RIOK1 6p24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p21;p24) UHRF1BP1/RIOK1


External links

Nomenclature
HGNC (Hugo)RIOK1   18656
Cards
Entrez_Gene (NCBI)RIOK1  83732  RIO kinase 1
AliasesAD034; RIO1; RRP10; bA288G3.1
GeneCards (Weizmann)RIOK1
Ensembl hg19 (Hinxton)ENSG00000124784 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124784 [Gene_View]  ENSG00000124784 [Sequence]  chr6:7389829-7418037 [Contig_View]  RIOK1 [Vega]
ICGC DataPortalENSG00000124784
TCGA cBioPortalRIOK1
AceView (NCBI)RIOK1
Genatlas (Paris)RIOK1
WikiGenes83732
SOURCE (Princeton)RIOK1
Genetics Home Reference (NIH)RIOK1
Genomic and cartography
GoldenPath hg38 (UCSC)RIOK1  -     chr6:7389829-7418037 +  6p24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIOK1  -     6p24.3   [Description]    (hg19-Feb_2009)
EnsemblRIOK1 - 6p24.3 [CytoView hg19]  RIOK1 - 6p24.3 [CytoView hg38]
Mapping of homologs : NCBIRIOK1 [Mapview hg19]  RIOK1 [Mapview hg38]
OMIM617753   
Gene and transcription
Genbank (Entrez)AF258661 AK054568 AK314467 AL834277 AY094356
RefSeq transcript (Entrez)NM_001348194 NM_031480 NM_153005
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RIOK1
Cluster EST : UnigeneHs.437474 [ NCBI ]
CGAP (NCI)Hs.437474
Alternative Splicing GalleryENSG00000124784
Gene ExpressionRIOK1 [ NCBI-GEO ]   RIOK1 [ EBI - ARRAY_EXPRESS ]   RIOK1 [ SEEK ]   RIOK1 [ MEM ]
Gene Expression Viewer (FireBrowse)RIOK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83732
GTEX Portal (Tissue expression)RIOK1
Human Protein AtlasENSG00000124784-RIOK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BRS2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BRS2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BRS2
Splice isoforms : SwissVarQ9BRS2
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9BRS2
Domaine pattern : Prosite (Expaxy)RIO1 (PS01245)   
Domains : Interpro (EBI)Kinase-like_dom_sf    RIO_kinase    RIO_kinase_CS    Ser/Thr_kinase_Rio1   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)RIO (SM00090)  
Conserved Domain (NCBI)RIOK1
DMDM Disease mutations83732
Blocks (Seattle)RIOK1
PDB (SRS)4OTP   
PDB (PDBSum)4OTP   
PDB (IMB)4OTP   
PDB (RSDB)4OTP   
Structural Biology KnowledgeBase4OTP   
SCOP (Structural Classification of Proteins)4OTP   
CATH (Classification of proteins structures)4OTP   
SuperfamilyQ9BRS2
Human Protein Atlas [tissue]ENSG00000124784-RIOK1 [tissue]
Peptide AtlasQ9BRS2
HPRD17978
IPIIPI00171336   IPI00171257   IPI00944921   
Protein Interaction databases
DIP (DOE-UCLA)Q9BRS2
IntAct (EBI)Q9BRS2
FunCoupENSG00000124784
BioGRIDRIOK1
STRING (EMBL)RIOK1
ZODIACRIOK1
Ontologies - Pathways
QuickGOQ9BRS2
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytosol  cytosol  cytosol  protein phosphorylation  hydrolase activity  maturation of SSU-rRNA  maturation of SSU-rRNA  preribosome, small subunit precursor  preribosome, small subunit precursor  methyltransferase complex  ribosomal small subunit biogenesis  metal ion binding  positive regulation of rRNA processing  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytosol  cytosol  cytosol  protein phosphorylation  hydrolase activity  maturation of SSU-rRNA  maturation of SSU-rRNA  preribosome, small subunit precursor  preribosome, small subunit precursor  methyltransferase complex  ribosomal small subunit biogenesis  metal ion binding  positive regulation of rRNA processing  
Pathways : KEGGRibosome biogenesis in eukaryotes   
NDEx NetworkRIOK1
Atlas of Cancer Signalling NetworkRIOK1
Wikipedia pathwaysRIOK1
Orthology - Evolution
OrthoDB83732
GeneTree (enSembl)ENSG00000124784
Phylogenetic Trees/Animal Genes : TreeFamRIOK1
HOVERGENQ9BRS2
HOGENOMQ9BRS2
Homologs : HomoloGeneRIOK1
Homology/Alignments : Family Browser (UCSC)RIOK1
Gene fusions - Rearrangements
Fusion : MitelmanUHRF1BP1/RIOK1 [6p21.31/6p24.3]  [t(6;6)(p21;p24)]  
Fusion PortalUHRF1BP1 6p21.31 RIOK1 6p24.3 PRAD
Fusion : QuiverRIOK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIOK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIOK1
dbVarRIOK1
ClinVarRIOK1
1000_GenomesRIOK1 
Exome Variant ServerRIOK1
ExAC (Exome Aggregation Consortium)ENSG00000124784
GNOMAD BrowserENSG00000124784
Varsome BrowserRIOK1
Genetic variants : HAPMAP83732
Genomic Variants (DGV)RIOK1 [DGVbeta]
DECIPHERRIOK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIOK1 
Mutations
ICGC Data PortalRIOK1 
TCGA Data PortalRIOK1 
Broad Tumor PortalRIOK1
OASIS PortalRIOK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIOK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRIOK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIOK1
DgiDB (Drug Gene Interaction Database)RIOK1
DoCM (Curated mutations)RIOK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIOK1 (select a term)
intoGenRIOK1
Cancer3DRIOK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617753   
Orphanet
DisGeNETRIOK1
MedgenRIOK1
Genetic Testing Registry RIOK1
NextProtQ9BRS2 [Medical]
TSGene83732
GENETestsRIOK1
Target ValidationRIOK1
Huge Navigator RIOK1 [HugePedia]
snp3D : Map Gene to Disease83732
BioCentury BCIQRIOK1
ClinGenRIOK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83732
Chemical/Pharm GKB GenePA134928236
Clinical trialRIOK1
Miscellaneous
canSAR (ICR)RIOK1 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIOK1
EVEXRIOK1
GoPubMedRIOK1
iHOPRIOK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:35:41 CET 2018

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