RIOK2 (RIO kinase 2)

2006-10-01  

Identity

HGNC
LOCATION
5q15
LOCUSID
ALIAS
RIO2

Other Information

Locus ID:

NCBI: 55781
MIM: 617754
HGNC: 18999
Ensembl: ENSG00000058729

Variants:

dbSNP: 55781
ClinVar: 55781
TCGA: ENSG00000058729
COSMIC: RIOK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000058729ENST00000283109Q9BVS4
ENSG00000058729ENST00000508447Q9BVS4
ENSG00000058729ENST00000510384D6RB96
ENSG00000058729ENST00000511012H0Y919
ENSG00000058729ENST00000511293H0Y8R4

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195644022009Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2.67
195788762009The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.39
234595922013A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma.33
218807102011Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression.9
273465592016High Expression of RIOK2 and NOB1 Predict Human Non-small Cell Lung Cancer Outcomes.7
297494342018miR‑145 inhibits human non‑small-cell lung cancer growth by dual-targeting RIOK2 and NOB1.7
258918992015Discovery of selective RIO2 kinase small molecule ligand.3
313909392019In vitro dimerization of human RIO2 kinase.1

Citation

Dessen P

RIOK2 (RIO kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43471/riok2