Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RIOK3 (RIO kinase 3)

Identity

Alias_namesSUDD
sudD (suppressor of bimD6, Aspergillus nidulans) homolog
RIO kinase 3 (yeast)
Other alias
HGNC (Hugo) RIOK3
LocusID (NCBI) 8780
Atlas_Id 50669
Location 18q11.2  [Link to chromosome band 18q11]
Location_base_pair Starts at 23453221 and ends at 23483140 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
OSBPL1A (18q11.2) / RIOK3 (18q11.2)RIOK3 (18q11.2) / RIOK3 (18q11.2)RIOK3 (18q11.2) / TAF4B (18q11.2)
OSBPL1A 18q11.2 / RIOK3 18q11.2RIOK3 18q11.2 / TAF4B 18q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)RIOK3   11451
Cards
Entrez_Gene (NCBI)RIOK3  8780  RIO kinase 3
AliasesSUDD
GeneCards (Weizmann)RIOK3
Ensembl hg19 (Hinxton)ENSG00000101782 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101782 [Gene_View]  chr18:23453221-23483140 [Contig_View]  RIOK3 [Vega]
ICGC DataPortalENSG00000101782
TCGA cBioPortalRIOK3
AceView (NCBI)RIOK3
Genatlas (Paris)RIOK3
WikiGenes8780
SOURCE (Princeton)RIOK3
Genetics Home Reference (NIH)RIOK3
Genomic and cartography
GoldenPath hg38 (UCSC)RIOK3  -     chr18:23453221-23483140 +  18q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIOK3  -     18q11.2   [Description]    (hg19-Feb_2009)
EnsemblRIOK3 - 18q11.2 [CytoView hg19]  RIOK3 - 18q11.2 [CytoView hg38]
Mapping of homologs : NCBIRIOK3 [Mapview hg19]  RIOK3 [Mapview hg38]
OMIM603579   
Gene and transcription
Genbank (Entrez)AF013591 AK024958 AK057292 AK303938 AK304571
RefSeq transcript (Entrez)NM_001348193 NM_003831 NM_145906
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RIOK3
Cluster EST : UnigeneHs.728452 [ NCBI ]
CGAP (NCI)Hs.728452
Alternative Splicing GalleryENSG00000101782
Gene ExpressionRIOK3 [ NCBI-GEO ]   RIOK3 [ EBI - ARRAY_EXPRESS ]   RIOK3 [ SEEK ]   RIOK3 [ MEM ]
Gene Expression Viewer (FireBrowse)RIOK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8780
GTEX Portal (Tissue expression)RIOK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14730   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14730  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14730
Splice isoforms : SwissVarO14730
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusO14730
Domaine pattern : Prosite (Expaxy)RIO1 (PS01245)   
Domains : Interpro (EBI)Kinase-like_dom    RIO_kinase    RIO_kinase_CS    Ser/Thr_kinase_Rio3   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)RIO (SM00090)  
Conserved Domain (NCBI)RIOK3
DMDM Disease mutations8780
Blocks (Seattle)RIOK3
SuperfamilyO14730
Human Protein AtlasENSG00000101782
Peptide AtlasO14730
HPRD04659
IPIIPI00298199   IPI00375164   IPI00908828   
Protein Interaction databases
DIP (DOE-UCLA)O14730
IntAct (EBI)O14730
FunCoupENSG00000101782
BioGRIDRIOK3
STRING (EMBL)RIOK3
ZODIACRIOK3
Ontologies - Pathways
QuickGOO14730
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  cytosol  rRNA processing  protein phosphorylation  chromosome segregation  maturation of SSU-rRNA  preribosome, small subunit precursor  negative regulation of protein homooligomerization  positive regulation of interferon-beta production  negative regulation of MDA-5 signaling pathway  negative regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  positive regulation of innate immune response  metal ion binding  defense response to virus  cellular response to dsRNA  caspase binding  cellular response to virus  cellular response to dsDNA  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  cytosol  rRNA processing  protein phosphorylation  chromosome segregation  maturation of SSU-rRNA  preribosome, small subunit precursor  negative regulation of protein homooligomerization  positive regulation of interferon-beta production  negative regulation of MDA-5 signaling pathway  negative regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  positive regulation of innate immune response  metal ion binding  defense response to virus  cellular response to dsRNA  caspase binding  cellular response to virus  cellular response to dsDNA  
NDEx NetworkRIOK3
Atlas of Cancer Signalling NetworkRIOK3
Wikipedia pathwaysRIOK3
Orthology - Evolution
OrthoDB8780
GeneTree (enSembl)ENSG00000101782
Phylogenetic Trees/Animal Genes : TreeFamRIOK3
HOVERGENO14730
HOGENOMO14730
Homologs : HomoloGeneRIOK3
Homology/Alignments : Family Browser (UCSC)RIOK3
Gene fusions - Rearrangements
Fusion : MitelmanOSBPL1A/RIOK3 [18q11.2/18q11.2]  [t(18;18)(q11;q11)]  
Fusion : MitelmanRIOK3/TAF4B [18q11.2/18q11.2]  [t(18;18)(q11;q11)]  
Fusion: TCGAOSBPL1A 18q11.2 RIOK3 18q11.2 HNSC
Fusion: TCGARIOK3 18q11.2 TAF4B 18q11.2 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIOK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIOK3
dbVarRIOK3
ClinVarRIOK3
1000_GenomesRIOK3 
Exome Variant ServerRIOK3
ExAC (Exome Aggregation Consortium)RIOK3 (select the gene name)
Genetic variants : HAPMAP8780
Genomic Variants (DGV)RIOK3 [DGVbeta]
DECIPHERRIOK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIOK3 
Mutations
ICGC Data PortalRIOK3 
TCGA Data PortalRIOK3 
Broad Tumor PortalRIOK3
OASIS PortalRIOK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIOK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRIOK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIOK3
DgiDB (Drug Gene Interaction Database)RIOK3
DoCM (Curated mutations)RIOK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIOK3 (select a term)
intoGenRIOK3
Cancer3DRIOK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603579   
Orphanet
MedgenRIOK3
Genetic Testing Registry RIOK3
NextProtO14730 [Medical]
TSGene8780
GENETestsRIOK3
Target ValidationRIOK3
Huge Navigator RIOK3 [HugePedia]
snp3D : Map Gene to Disease8780
BioCentury BCIQRIOK3
ClinGenRIOK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8780
Chemical/Pharm GKB GenePA36248
Clinical trialRIOK3
Miscellaneous
canSAR (ICR)RIOK3 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIOK3
EVEXRIOK3
GoPubMedRIOK3
iHOPRIOK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:53:20 CEST 2017

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