RIOK3 (RIO kinase 3)

2009-02-01  

Identity

HGNC
RIOK3
LOCATION
18q11.2
LOCUSID
8780
ALIAS
SUDD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8780
MIM: 603579
HGNC: 11451
Ensembl: ENSG00000101782

Variants:

dbSNP: 8780
ClinVar: 8780
TCGA: ENSG00000101782
COSMIC: RIOK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101782ENST00000339486O14730
ENSG00000101782ENST00000339486B0YJ89
ENSG00000101782ENST00000577250J3QLP4
ENSG00000101782ENST00000577501O14730
ENSG00000101782ENST00000581585B4E1Q4
ENSG00000101782ENST00000584130J3QQL5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190500742008Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.59
258658832015RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.21
224188432012Human RioK3 is a novel component of cytoplasmic pre-40S pre-ribosomal particles.13
248077082014RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.10
254864362015Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis.8
292336562018The atypical protein kinase RIOK3 contributes to glioma cell proliferation/survival, migration/invasion and the AKT/mTOR signaling pathway.8
240180502013RIO kinase 3 acts as a SUFU-dependent positive regulator of Hedgehog signaling.6

Citation

Dessen P

RIOK3 (RIO kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-02-01

Online version: http://atlasgeneticsoncology.org/gene/50669/riok3