Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RIPK1 (receptor interacting serine/threonine kinase 1)

Identity

Alias_namesreceptor (TNFRSF)-interacting serine-threonine kinase 1
Alias_symbol (synonym)RIP
Other aliasIMD57
RIP-1
RIP1
HGNC (Hugo) RIPK1
LocusID (NCBI) 8737
Atlas_Id 42119
Location 6p25.2  [Link to chromosome band 6p25]
Location_base_pair Starts at 3063841 and ends at 3115192 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RIPK1 (6p25.2) / NQO2 (6p25.2)RIPK1 (6p25.2) / RIPK1 (6p25.2)RIPK1 (6p25.2) / SERPINB9 (6p25.2)
RIPK1 6p25.2 / NQO2 6p25.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  RIPK1/NQO2 (6p25)
RIPK1/SERPINB9 (6p25)


External links

Nomenclature
HGNC (Hugo)RIPK1   10019
Cards
Entrez_Gene (NCBI)RIPK1  8737  receptor interacting serine/threonine kinase 1
AliasesIMD57; RIP; RIP-1; RIP1
GeneCards (Weizmann)RIPK1
Ensembl hg19 (Hinxton)ENSG00000137275 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137275 [Gene_View]  ENSG00000137275 [Sequence]  chr6:3063841-3115192 [Contig_View]  RIPK1 [Vega]
ICGC DataPortalENSG00000137275
TCGA cBioPortalRIPK1
AceView (NCBI)RIPK1
Genatlas (Paris)RIPK1
WikiGenes8737
SOURCE (Princeton)RIPK1
Genetics Home Reference (NIH)RIPK1
Genomic and cartography
GoldenPath hg38 (UCSC)RIPK1  -     chr6:3063841-3115192 +  6p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIPK1  -     6p25.2   [Description]    (hg19-Feb_2009)
EnsemblRIPK1 - 6p25.2 [CytoView hg19]  RIPK1 - 6p25.2 [CytoView hg38]
Mapping of homologs : NCBIRIPK1 [Mapview hg19]  RIPK1 [Mapview hg38]
OMIM603453   618108   
Gene and transcription
Genbank (Entrez)AB208926 AJ420482 AK096523 AK304701 AK314176
RefSeq transcript (Entrez)NM_001317061 NM_001354930 NM_001354931 NM_001354932 NM_001354933 NM_001354934 NM_003804
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RIPK1
Cluster EST : UnigeneHs.519842 [ NCBI ]
CGAP (NCI)Hs.519842
Alternative Splicing GalleryENSG00000137275
Gene ExpressionRIPK1 [ NCBI-GEO ]   RIPK1 [ EBI - ARRAY_EXPRESS ]   RIPK1 [ SEEK ]   RIPK1 [ MEM ]
Gene Expression Viewer (FireBrowse)RIPK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8737
GTEX Portal (Tissue expression)RIPK1
Human Protein AtlasENSG00000137275-RIPK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13546   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13546  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13546
Splice isoforms : SwissVarQ13546
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ13546
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)DEATH-like_dom_sf    Death_domain    Kinase-like_dom_sf    Prot_kinase_dom    RHIM_dom    RIP1_Death    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Death (PF00531)    Pkinase_Tyr (PF07714)    RHIM (PF12721)   
Domain families : Pfam (NCBI)pfam00531    pfam07714    pfam12721   
Domain families : Smart (EMBL)DEATH (SM00005)  S_TKc (SM00220)  
Conserved Domain (NCBI)RIPK1
DMDM Disease mutations8737
Blocks (Seattle)RIPK1
PDB (SRS)4ITH    4ITI    4ITJ    4NEU    5HX6    5TX5   
PDB (PDBSum)4ITH    4ITI    4ITJ    4NEU    5HX6    5TX5   
PDB (IMB)4ITH    4ITI    4ITJ    4NEU    5HX6    5TX5   
PDB (RSDB)4ITH    4ITI    4ITJ    4NEU    5HX6    5TX5   
Structural Biology KnowledgeBase4ITH    4ITI    4ITJ    4NEU    5HX6    5TX5   
SCOP (Structural Classification of Proteins)4ITH    4ITI    4ITJ    4NEU    5HX6    5TX5   
CATH (Classification of proteins structures)4ITH    4ITI    4ITJ    4NEU    5HX6    5TX5   
SuperfamilyQ13546
Human Protein Atlas [tissue]ENSG00000137275-RIPK1 [tissue]
Peptide AtlasQ13546
HPRD04583
IPIIPI00013773   IPI00939198   IPI00902882   
Protein Interaction databases
DIP (DOE-UCLA)Q13546
IntAct (EBI)Q13546
FunCoupENSG00000137275
BioGRIDRIPK1
STRING (EMBL)RIPK1
ZODIACRIPK1
Ontologies - Pathways
QuickGOQ13546
Ontology : AmiGOMAPK cascade  positive regulation of protein phosphorylation  MyD88-independent toll-like receptor signaling pathway  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  death receptor binding  protein binding  ATP binding  mitochondrion  cytosol  cytosol  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  I-kappaB kinase/NF-kappaB signaling  activation of JNKK activity  activation of JUN kinase activity  activation of JUN kinase activity  endosome membrane  regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of necrotic cell death  viral process  protein deubiquitination  death-inducing signaling complex  ubiquitin protein ligase binding  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  toll-like receptor 3 signaling pathway  response to tumor necrosis factor  TRIF-dependent toll-like receptor signaling pathway  peptidyl-serine autophosphorylation  identical protein binding  positive regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of programmed cell death  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of I-kappaB kinase/NF-kappaB signaling  receptor complex  cellular protein catabolic process  protein-containing complex binding  membrane raft  positive regulation of macrophage differentiation  positive regulation of transcription by RNA polymerase II  positive regulation of JNK cascade  protein autophosphorylation  positive regulation of NF-kappaB transcription factor activity  protein homooligomerization  protein heterooligomerization  positive regulation of necroptotic process  T cell apoptotic process  necroptotic process  necroptotic process  necroptotic process  death domain binding  regulation of ATP:ADP antiporter activity  cellular response to tumor necrosis factor  cellular response to growth factor stimulus  death-inducing signaling complex assembly  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway  ripoptosome  ripoptosome assembly  necroptotic signaling pathway  necroptotic signaling pathway  ripoptosome assembly involved in necroptotic process  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of hydrogen peroxide-induced cell death  amyloid fibril formation  positive regulation of reactive oxygen species metabolic process  negative regulation of extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIMAPK cascade  positive regulation of protein phosphorylation  MyD88-independent toll-like receptor signaling pathway  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  death receptor binding  protein binding  ATP binding  mitochondrion  cytosol  cytosol  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  I-kappaB kinase/NF-kappaB signaling  activation of JNKK activity  activation of JUN kinase activity  activation of JUN kinase activity  endosome membrane  regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of necrotic cell death  viral process  protein deubiquitination  death-inducing signaling complex  ubiquitin protein ligase binding  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  toll-like receptor 3 signaling pathway  response to tumor necrosis factor  TRIF-dependent toll-like receptor signaling pathway  peptidyl-serine autophosphorylation  identical protein binding  positive regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of programmed cell death  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of I-kappaB kinase/NF-kappaB signaling  receptor complex  cellular protein catabolic process  protein-containing complex binding  membrane raft  positive regulation of macrophage differentiation  positive regulation of transcription by RNA polymerase II  positive regulation of JNK cascade  protein autophosphorylation  positive regulation of NF-kappaB transcription factor activity  protein homooligomerization  protein heterooligomerization  positive regulation of necroptotic process  T cell apoptotic process  necroptotic process  necroptotic process  necroptotic process  death domain binding  regulation of ATP:ADP antiporter activity  cellular response to tumor necrosis factor  cellular response to growth factor stimulus  death-inducing signaling complex assembly  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway  ripoptosome  ripoptosome assembly  necroptotic signaling pathway  necroptotic signaling pathway  ripoptosome assembly involved in necroptotic process  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of hydrogen peroxide-induced cell death  amyloid fibril formation  positive regulation of reactive oxygen species metabolic process  negative regulation of extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGNF-kappa B signaling pathway    Apoptosis    Toll-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    TNF signaling pathway    Hepatitis C    Epstein-Barr virus infection   
NDEx NetworkRIPK1
Atlas of Cancer Signalling NetworkRIPK1
Wikipedia pathwaysRIPK1
Orthology - Evolution
OrthoDB8737
GeneTree (enSembl)ENSG00000137275
Phylogenetic Trees/Animal Genes : TreeFamRIPK1
HOVERGENQ13546
HOGENOMQ13546
Homologs : HomoloGeneRIPK1
Homology/Alignments : Family Browser (UCSC)RIPK1
Gene fusions - Rearrangements
Fusion : MitelmanRIPK1/NQO2 [6p25.2/6p25.2]  
Fusion : MitelmanRIPK1/SERPINB9 [6p25.2/6p25.2]  [t(6;6)(p25;p25)]  
Fusion PortalRIPK1 6p25.2 NQO2 6p25.2 BRCA
Fusion : QuiverRIPK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIPK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIPK1
dbVarRIPK1
ClinVarRIPK1
1000_GenomesRIPK1 
Exome Variant ServerRIPK1
ExAC (Exome Aggregation Consortium)ENSG00000137275
GNOMAD BrowserENSG00000137275
Varsome BrowserRIPK1
Genetic variants : HAPMAP8737
Genomic Variants (DGV)RIPK1 [DGVbeta]
DECIPHERRIPK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIPK1 
Mutations
ICGC Data PortalRIPK1 
TCGA Data PortalRIPK1 
Broad Tumor PortalRIPK1
OASIS PortalRIPK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIPK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRIPK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIPK1
DgiDB (Drug Gene Interaction Database)RIPK1
DoCM (Curated mutations)RIPK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIPK1 (select a term)
intoGenRIPK1
Cancer3DRIPK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603453    618108   
Orphanet
DisGeNETRIPK1
MedgenRIPK1
Genetic Testing Registry RIPK1
NextProtQ13546 [Medical]
TSGene8737
GENETestsRIPK1
Target ValidationRIPK1
Huge Navigator RIPK1 [HugePedia]
snp3D : Map Gene to Disease8737
BioCentury BCIQRIPK1
ClinGenRIPK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8737
Chemical/Pharm GKB GenePA34394
Clinical trialRIPK1
Miscellaneous
canSAR (ICR)RIPK1 (select the gene name)
Probes
Litterature
PubMed343 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIPK1
EVEXRIPK1
GoPubMedRIPK1
iHOPRIPK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:35:42 CET 2018

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