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RIPK2 (receptor interacting serine/threonine kinase 2)

Identity

Alias_namesreceptor-interacting serine-threonine kinase 2
Alias_symbol (synonym)RICK
RIP2
CARDIAK
CARD3
Other aliasCCK
GIG30
HGNC (Hugo) RIPK2
LocusID (NCBI) 8767
Atlas_Id 42120
Location 8q21.3  [Link to chromosome band 8q21]
Location_base_pair Starts at 90769975 and ends at 90803292 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
OSGIN2 (8q21.3) / RIPK2 (8q21.3)SLC25A44 (1q22) / RIPK2 (8q21.3)OSGIN2 8q21.3 / RIPK2 8q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RIPK2   10020
Cards
Entrez_Gene (NCBI)RIPK2  8767  receptor interacting serine/threonine kinase 2
AliasesCARD3; CARDIAK; CCK; GIG30; 
RICK; RIP2
GeneCards (Weizmann)RIPK2
Ensembl hg19 (Hinxton)ENSG00000104312 [Gene_View]  chr8:90769975-90803292 [Contig_View]  RIPK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000104312 [Gene_View]  chr8:90769975-90803292 [Contig_View]  RIPK2 [Vega]
ICGC DataPortalENSG00000104312
TCGA cBioPortalRIPK2
AceView (NCBI)RIPK2
Genatlas (Paris)RIPK2
WikiGenes8767
SOURCE (Princeton)RIPK2
Genetics Home Reference (NIH)RIPK2
Genomic and cartography
GoldenPath hg19 (UCSC)RIPK2  -     chr8:90769975-90803292 +  8q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RIPK2  -     8q21.3   [Description]    (hg38-Dec_2013)
EnsemblRIPK2 - 8q21.3 [CytoView hg19]  RIPK2 - 8q21.3 [CytoView hg38]
Mapping of homologs : NCBIRIPK2 [Mapview hg19]  RIPK2 [Mapview hg38]
OMIM603455   
Gene and transcription
Genbank (Entrez)AF027706 AF064824 AF078530 AI824070 AK075213
RefSeq transcript (Entrez)NM_003821
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_033016 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)RIPK2
Cluster EST : UnigeneHs.103755 [ NCBI ]
CGAP (NCI)Hs.103755
Alternative Splicing GalleryENSG00000104312
Gene ExpressionRIPK2 [ NCBI-GEO ]   RIPK2 [ EBI - ARRAY_EXPRESS ]   RIPK2 [ SEEK ]   RIPK2 [ MEM ]
Gene Expression Viewer (FireBrowse)RIPK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8767
GTEX Portal (Tissue expression)RIPK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43353   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43353  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43353
Splice isoforms : SwissVarO43353
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusO43353
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)CARD    DEATH-like_dom    Kinase-like_dom    Prot_kinase_dom    Rcpt-int_Ser/Thr_kinase-2    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)CARD (PF00619)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam00619    pfam07714   
Domain families : Smart (EMBL)CARD (SM00114)  
Conserved Domain (NCBI)RIPK2
DMDM Disease mutations8767
Blocks (Seattle)RIPK2
PDB (SRS)2N7Z    2N83    4C8B    5AR2    5AR3    5AR4    5AR5    5AR7    5AR8   
PDB (PDBSum)2N7Z    2N83    4C8B    5AR2    5AR3    5AR4    5AR5    5AR7    5AR8   
PDB (IMB)2N7Z    2N83    4C8B    5AR2    5AR3    5AR4    5AR5    5AR7    5AR8   
PDB (RSDB)2N7Z    2N83    4C8B    5AR2    5AR3    5AR4    5AR5    5AR7    5AR8   
Structural Biology KnowledgeBase2N7Z    2N83    4C8B    5AR2    5AR3    5AR4    5AR5    5AR7    5AR8   
SCOP (Structural Classification of Proteins)2N7Z    2N83    4C8B    5AR2    5AR3    5AR4    5AR5    5AR7    5AR8   
CATH (Classification of proteins structures)2N7Z    2N83    4C8B    5AR2    5AR3    5AR4    5AR5    5AR7    5AR8   
SuperfamilyO43353
Human Protein AtlasENSG00000104312
Peptide AtlasO43353
HPRD04585
IPIIPI00021917   IPI00554774   IPI00816174   IPI00974445   
Protein Interaction databases
DIP (DOE-UCLA)O43353
IntAct (EBI)O43353
FunCoupENSG00000104312
BioGRIDRIPK2
STRING (EMBL)RIPK2
ZODIACRIPK2
Ontologies - Pathways
QuickGOO43353
Ontology : AmiGOactivation of MAPK activity  positive regulation of cytokine-mediated signaling pathway  adaptive immune response  protein serine/threonine kinase activity  non-membrane spanning protein tyrosine kinase activity  signal transducer activity  receptor binding  protein binding  ATP binding  cytoplasm  cytosol  cytoskeleton  apoptotic process  inflammatory response  signal transduction  I-kappaB kinase/NF-kappaB signaling  JNK cascade  positive regulation of peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  LIM domain binding  positive regulation of protein ubiquitination  positive regulation of protein ubiquitination  lipopolysaccharide-mediated signaling pathway  vesicle  positive regulation of chemokine production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-gamma production  positive regulation of interleukin-12 production  positive regulation of interleukin-2 production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  positive regulation of immature T cell proliferation  positive regulation of peptidyl-serine phosphorylation  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  T cell proliferation  protein homodimerization activity  positive regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein complex  response to exogenous dsRNA  innate immune response  innate immune response  positive regulation of T-helper 1 cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  positive regulation of alpha-beta T cell proliferation  CARD domain binding  CARD domain binding  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-positive bacterium  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of ERK1 and ERK2 cascade  nucleotide-binding oligomerization domain containing signaling pathway  nucleotide-binding oligomerization domain containing 1 signaling pathway  nucleotide-binding oligomerization domain containing 2 signaling pathway  response to interleukin-1  response to interleukin-12  response to interleukin-18  cellular response to lipoteichoic acid  cellular response to peptidoglycan  cellular response to muramyl dipeptide  positive regulation of xenophagy  
Ontology : EGO-EBIactivation of MAPK activity  positive regulation of cytokine-mediated signaling pathway  adaptive immune response  protein serine/threonine kinase activity  non-membrane spanning protein tyrosine kinase activity  signal transducer activity  receptor binding  protein binding  ATP binding  cytoplasm  cytosol  cytoskeleton  apoptotic process  inflammatory response  signal transduction  I-kappaB kinase/NF-kappaB signaling  JNK cascade  positive regulation of peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  LIM domain binding  positive regulation of protein ubiquitination  positive regulation of protein ubiquitination  lipopolysaccharide-mediated signaling pathway  vesicle  positive regulation of chemokine production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-gamma production  positive regulation of interleukin-12 production  positive regulation of interleukin-2 production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  positive regulation of immature T cell proliferation  positive regulation of peptidyl-serine phosphorylation  toll-like receptor 2 signaling pathway  toll-like receptor 4 signaling pathway  T cell proliferation  protein homodimerization activity  positive regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein complex  response to exogenous dsRNA  innate immune response  innate immune response  positive regulation of T-helper 1 cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  positive regulation of alpha-beta T cell proliferation  CARD domain binding  CARD domain binding  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-positive bacterium  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of ERK1 and ERK2 cascade  nucleotide-binding oligomerization domain containing signaling pathway  nucleotide-binding oligomerization domain containing 1 signaling pathway  nucleotide-binding oligomerization domain containing 2 signaling pathway  response to interleukin-1  response to interleukin-12  response to interleukin-18  cellular response to lipoteichoic acid  cellular response to peptidoglycan  cellular response to muramyl dipeptide  positive regulation of xenophagy  
Pathways : BIOCARTAFAS signaling pathway ( CD95 ) [Genes]   
Pathways : KEGGNOD-like receptor signaling pathway    Neurotrophin signaling pathway    Shigellosis    Tuberculosis   
NDEx NetworkRIPK2
Atlas of Cancer Signalling NetworkRIPK2
Wikipedia pathwaysRIPK2
Orthology - Evolution
OrthoDB8767
GeneTree (enSembl)ENSG00000104312
Phylogenetic Trees/Animal Genes : TreeFamRIPK2
HOVERGENO43353
HOGENOMO43353
Homologs : HomoloGeneRIPK2
Homology/Alignments : Family Browser (UCSC)RIPK2
Gene fusions - Rearrangements
Fusion : MitelmanOSGIN2/RIPK2 [8q21.3/8q21.3]  [t(8;8)(q21;q21)]  
Fusion: TCGAOSGIN2 8q21.3 RIPK2 8q21.3 BRCA HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIPK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIPK2
dbVarRIPK2
ClinVarRIPK2
1000_GenomesRIPK2 
Exome Variant ServerRIPK2
ExAC (Exome Aggregation Consortium)RIPK2 (select the gene name)
Genetic variants : HAPMAP8767
Genomic Variants (DGV)RIPK2 [DGVbeta]
DECIPHER (Syndromes)8:90769975-90803292  ENSG00000104312
CONAN: Copy Number AnalysisRIPK2 
Mutations
ICGC Data PortalRIPK2 
TCGA Data PortalRIPK2 
Broad Tumor PortalRIPK2
OASIS PortalRIPK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIPK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRIPK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIPK2
DgiDB (Drug Gene Interaction Database)RIPK2
DoCM (Curated mutations)RIPK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIPK2 (select a term)
intoGenRIPK2
Cancer3DRIPK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603455   
Orphanet
MedgenRIPK2
Genetic Testing Registry RIPK2
NextProtO43353 [Medical]
TSGene8767
GENETestsRIPK2
Huge Navigator RIPK2 [HugePedia]
snp3D : Map Gene to Disease8767
BioCentury BCIQRIPK2
ClinGenRIPK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8767
Chemical/Pharm GKB GenePA34395
Clinical trialRIPK2
Miscellaneous
canSAR (ICR)RIPK2 (select the gene name)
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIPK2
EVEXRIPK2
GoPubMedRIPK2
iHOPRIPK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:25:09 CET 2017

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